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Human LIF Protein expressed in Escherichia coli (E. coli) - ABIN2018195
Yu, Kastin, Pan: TNF reduces LIF endocytosis despite increasing NFkappaB-mediated gp130 expression. in Journal of cellular physiology 2007
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mouse embryonic stem cells inside microchambers formed colonies and expressed markers of pluripotency in the absence of feeders or pluripotency-inducing signals such as leukemia inhibitory factor.
Authors demonstrate heterozygous novel or rare LIFR (show LIFR Proteins) mutations in 3.3% of CAKUT patients, and provide evidence that Lifr (show LIFR Proteins) deficiency and deactivating LIFR (show LIFR Proteins) mutations cause highly similar anomalies of the urogenital tract in mice and humans.
lung epithelium, specifically alveolar type II cells, is the predominant site of LIF transcript induction in pneumonic mouse lungs.
LIF/STAT3 (show STAT3 Proteins) and MEK (show MDK Proteins)/ERK (show EPHB2 Proteins) signaling in naive embryonic stem cell pluripotency, is reported.
uterine expression of the LIFR (show LIFR Proteins) is essential for embryo implantation; this further define the components of the LIF signaling pathway necessary for effective implantation.
LIF stimulates, in part, stem cell-derived cardiomyocyte regeneration by activating cardiac stem or precursor cells.
Our data show that absence of SOCS2 (show SOCS2 Proteins) turns cardiomyocytes unresponsive to LIF-induced [Ca(2 (show CA2 Proteins)+)] raise, indicating that endogenous levels of SOCS2 (show SOCS2 Proteins) are crucial for full activation of LIF signaling in the heart.
OSM (mOSM) signals mainly via an OSM receptor (OSMR)-gp130 heterodimer and binds with only very low affinity to mLIFR.
These results establish that Bcl3 (show BCL3 Proteins) positively regulates pluripotency genes and thus shed light on the mechanism of Bcl3 (show BCL3 Proteins) as a downstream molecule of LIF/STAT3 (show STAT3 Proteins) signaling in pluripotency maintenance.
The role of LIF in acetylcholine synthesis via the STAT3 (show STAT3 Proteins), PI3 (show PI3 Proteins) kinases, or cAMP-protein kinase A pathways, are reported.
ATF3 (show ATF3 Proteins) plays a significant role in regulating human endometrial receptivity and embryo attachment in vitro via up-regulation of leukemia inhibitory factor.
Although further studies would be required to deconvolute the targets involved in LIF induction and to confirm activity of hits in more disease-relevant assays, our results have demonstrated the potential of the phenotypic approach to identify specific and chemically tractable small molecules that trigger the production of LIF in relevant cell lines
SNP 3951C/T of LIF may not be associated with in vitro fertilization and embryo transfer outcome in Iranian population.
In summary, this study has shown that LIF is implicated in the HG-mediated inhibition of osteoblast differentiation, via promoting STAT3 (show STAT3 Proteins)/SOCS3 (show SOCS3 Proteins) signaling. This study may provide insights into the signal pathway of HG-induced bone loss or delayed injured joint healing.
Cytokines of the LIF/CNTF (show CNTF Proteins) family and metabolism
These results demonstrate the involvement of PIM (show PIM1 Proteins) kinases in LIF-induced regulation in different trophoblastic cell lines which may indicate similar functions in primary cells.
Data suggest a 216-nucleotide proximal cis (show CISH Proteins)-element in LIF mRNA exhibits mRNA destabilizing potential; on exposure to carcinogen PMA (phorbol-12-myristate-13-acetate), this cis (show CISH Proteins)-element exhibits mRNA stabilizing activity. PMA induces nucleo-cytoplasmic translocation of both nucleolin (show NCL Proteins) and PCBP1 (show PCBP1 Proteins), 2 trans-acting factors that bind to and stabilize LIF mRNA. [LIF = leukemia inhibitory factor; PCBP1 (show PCBP1 Proteins) = poly(rC) binding protein 1 (show PCBP1 Proteins)]
Leukemia inhibitory factor (LIF) - STAT3 (show STAT3 Proteins) transcription factor (STAT3 (show STAT3 Proteins)) signaling pathway is systemically dysregulated in in the endometrium of patients with recurrent/repeated implantation failure (RIFE).
Endometrial expression of LIF and LIFR (show LIFR Proteins) is significantly reduced in the epithelial cells of infertile women.
LIF SNP T/G (rs929271) seems to be a susceptibility biomarker capable of predicting implantation efficiency and pregnancy outcomes.
Cell cycle synchronization of leukemia inhibitory factor (LIF)-dependent porcine-induced pluripotent stem cells and the generation of cloned embryos.
Studied effect of recombinant porcine leukemia inhibitory factor on in vitro maturation of porcine oocytes; p-STAT3 (show STAT3 Proteins) markedly increased in both cumulus cells and oocytes cultured in pLIF (show FTH1 Proteins)-supplemented media.
LIF and IL-6 (show IL6 Proteins) are important components of embryo-uterine interactions during early pregnancy in the pig, and may contribute to successful conceptus implantation.
Reprogramming pig fetal fibroblasts reveals a functional LIF signaling pathway.
favorable effect on litter size in pigs of the A allele for a SNP within the LIF gene
LIF (Leukemia inhibitory factor) mRNA was elevated in stented segments of coronary arteries; vascular smooth muscle cell proliferation was inhibited by LIF treatment in an in-vitro model of atherosclerosis
study found significant association of two diallelic polymorphisms in the porcine genes for leukaemia inhibitory factor (LIF) and retinol-binding protein 4 (RBP4 (show RBP4 Proteins)) with number of piglets born alive (NBA) in two German pig lines
Studied the effects of leukemia inhibitory factor (LIF) on bovine oocyte maturation and early embryo development in vitro.
results suggest that leukemia inhibitory factor and macrophage-colony stimulating factor (show CSF2 Proteins) are produced in the endometrium and may play different roles in early and mid-pregnancy
The protein encoded by this gene is a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role in immune tolerance at the maternal-fetal interface. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
, cholinergic differentiation factor
, differentiation inhibitory activity
, differentiation-inducing factor
, differentiation-stimulating factor
, hepatocyte-stimulating factor III
, human interleukin in DA cells
, melanoma-derived LPL inhibitor
, d factor
, leukemia inhibitory factor (cholinergic differentiation factor)
, D-factor/LIF receptor
, LIF receptor
, leukemia inhibitory factor receptor alpha chain
, soluble differentiation-stimulating factor receptor
, cholinergic neuronal differentiation factor
, leukemia inhibitory factor
, Leukemia Inhibitory Factor (LIF)