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Authors demonstrate heterozygous novel or rare LIFR mutations in 3.3% of CAKUT patients, and provide evidence that Lifr deficiency and deactivating LIFR mutations cause highly similar anomalies of the urogenital tract in mice and humans.
uterine expression of the LIFR is essential for embryo implantation; this further define the components of the LIF (show LIF Proteins) signaling pathway necessary for effective implantation.
OSM (mOSM) signals mainly via an OSM receptor (OSMR)-gp130 heterodimer and binds with only very low affinity to mLIFR.
The predominant role of leukemia inhibitory factor receptor in skeletal muscle regeneration appears to be in regulating the inflammatory response rather than directly effecting myogenic cells.
both LIFR and gp130 protein expression were increased in the sciatic nerve and gastrocnemius muscle of diabetic mice.
Data confirmed that LIF (show LIF Proteins) and the LIFR were up-regulated in intra-implantation sites compared to inter-implantation sites on Day 5 of gestation.
Data demonstrate that T cells retain responsiveness to a LIF (show LIF Proteins)/Nanog (show NANOG Proteins) axis and that this axis is linked to MARCH-7, a RINGv E3 ligase that regulates the LIF-receptor.
Neuropoietin (show CTF2 Proteins) induced activation of STAT3 (show STAT3 Proteins) tyrosine phosphorylation in adipocytes is independent of LIFR phosphorylation and degradation.
Review. The structure and function of the LIF-R gene and protein and the role of its cytoplasmic domain in myeloid leukemia (show BCL11A Proteins) cells are reviewed.
LIFR plays a role in modulating fetal response to high maternal glucocorticoids in late gestation, likely mediated through the glucocorticoid receptor (show NR3C1 Proteins), with implications for adult homeostasis as a direct tie between immune, neural & hormone function.
Significant reduction in LIFR expression and the reduced activation of subsequent signaling strongly suggest a working model of how the implantation markers, LIF (show LIF Proteins), may affect the endometrium of patients with adenomyosis.
study indicated impaired LIF (show LIF Proteins) expression levels only in women with unexplained infertility, while LIF-R expression was impaired in all sub-groups of infertile women.
Expression of cancer-specific glycan epitopes represents an excellent opportunity for diagnostics and potentially specific detection of tumors. Here, we report four proteins (LIFR, CE350, VP13A, HPT) found in sera from pancreatic cancer patients carrying aberrant glycan structures as compared to those of controls.
Endometrial expression of LIF (show LIF Proteins) and LIFR is significantly reduced in the epithelial cells of infertile women.
LIFR inhibited the expression of beta-catenin (show CTNNB1 Proteins).
The Leukemia Inhibitory Factor Receptor Gene Is a Direct Target of RUNX1 (show RUNX1 Proteins)
The C65S mutant LIFR showed altered glycosylation and an elevated expression level that might be attributed to a slow turnover of the mutant form.
High LIFr expression stimulates melanoma cell migration and is associated with unfavorable prognosis in melanoma.
Stuve-Wiedemann syndrome patients with (p.Arg692X) LIFR mutation may develop central adrenal insufficiency due to impaired LIF/LIFR signalling. LIF/LIFR system plays a role in human HPA (show HPSE Proteins) axis regulation.
This gene encodes a protein that belongs to the type I cytokine receptor family. This protein combines with a high-affinity converter subunit, gp130, to form a receptor complex that mediates the action of the leukemia inhibitory factor, a polyfunctional cytokine that is involved in cellular differentiation, proliferation and survival in the adult and the embryo. Mutations in this gene cause Schwartz-Jampel syndrome type 2, a disease belonging to the group of the bent-bone dysplasias. A translocation that involves the promoter of this gene, t(5\;8)(p13\;q12) with the pleiomorphic adenoma gene 1, is associated with salivary gland pleiomorphic adenoma, a common type of benign epithelial tumor of the salivary gland. Multiple splice variants encoding the same protein have been found for this gene.
, LIF receptor
, leukemia inhibitory factor receptor alpha chain
, soluble differentiation-stimulating factor receptor
, CD118 antigen
, leukemia inhibitory factor receptor
, leukemia inhibitor factor receptor alpha-chain
, cytokine receptor-beta