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MPL Proteins

(Myeloproliferative Leukemia Virus Oncogene (MPL))

In 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue, named, c-mpl, was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. The ligand for c-mpl, thrombopoietin, was cloned in 1994. Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs . TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated. [provided by RefSeq, Jul 2008].

recommended

MPL Protein (AA 26-491) (His tag) (ABIN7275276)

MPL Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

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recommended

MPL Protein (AA 26-635) (MBP tag,His tag) (ABIN3113551)

Crystallography grade MPL Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys

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recommended

MPL Protein (AA 26-482) (His tag) (ABIN7275277)

MPL Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

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MPL Proteins by Grade

Find MPL Proteins with a specific Grade. The Grade listed below are among those available. Click on a link to go to the corresponding products.

MPL Proteins by Origin

Find MPL Proteins for a variety of species such as anti-Human MPL, anti-Mouse MPL, anti-Cynomolgus MPL. The species listed below are among those available. Click on a link to go to the corresponding products.

MPL Proteins by Source

Here you will find MPL Proteins proteins organized by several key sources. By clicking on a link, you can access the products. For additional sources, please use our search function.

MPL Proteins by Protein Type

Here you can find MPL Proteins proteins categorized by available protein types. Additional protein types can be located using our search function.

MPL Proteins by Application

Find MPL Proteins validated for a specific application such as SDS, WB, ELISA, Crys. Some of the available applications are listed below. Click on a link to go to the corresponding products.

Popular MPL Proteins

Product

Reactivity

Source

Validations

Cat. No.

Quantity

Datasheet

MPL Protein (AA 26-491) (His tag)

Reactivity Human

Source HEK-293 Cells

Validations

Cat. No. ABIN7275276

Quantity 100 μg

Datasheet Datasheet

MPL Protein (AA 26-635) (MBP tag,His tag)

Reactivity Human

Source Insect Cells

Validations

Cat. No. ABIN3113551

Quantity 1 mg

Datasheet Datasheet

MPL Protein (AA 26-482) (His tag)

Reactivity Mouse

Source HEK-293 Cells

Validations

Cat. No. ABIN7275277

Quantity 100 μg

Datasheet Datasheet

MPL Protein (AA 1-635) (GST tag)

Reactivity Human

Source Wheat germ

Validations

Cat. No. ABIN1311206

Quantity 10 μg

Datasheet Datasheet

MPL Protein (AA 26-491) (His tag)

Reactivity Human

Source Escherichia coli (E. coli)

Validations

Cat. No. ABIN7124044

Quantity 50 μg

Datasheet Datasheet

MPL Protein (His tag)

Reactivity Rat

Source Baculovirus infected Insect Cells

Validations

Cat. No. ABIN7321113

Quantity 100 μg

Datasheet Datasheet

MPL Protein (AA 514-635) (His tag)

Reactivity Human

Source Insect Cells

Validations

Cat. No. ABIN3074647

Quantity 1 mg

Datasheet Datasheet

MPL Protein (AA 505-625) (His tag)

Reactivity Mouse

Source Insect Cells

Validations

Cat. No. ABIN3121514

Quantity 1 mg

Datasheet Datasheet

MPL Protein (AA 26-491) (His tag)

Reactivity Human

Source Insect Cells

Validations

Cat. No. ABIN3074646

Quantity 1 mg

Datasheet Datasheet

MPL Protein (AA 26-482) (His tag)

Reactivity Mouse

Source Insect Cells

Validations

Cat. No. ABIN3121512

Quantity 1 mg

Datasheet Datasheet

MPL Protein (AA 26-625) (rho-1D4 tag)

Reactivity Mouse

Source Insect Cells

Validations

Cat. No. ABIN3121513

Quantity 1 mg

Datasheet Datasheet

MPL Protein (AA 22-489) (His tag)

Reactivity Cynomolgus

Source HEK-293 Cells

Validations

Cat. No. ABIN7454193

Quantity 100 μg

Datasheet Datasheet

MPL Protein (Fc Tag)

Reactivity Human

Source HEK-293 Cells

Validations

Cat. No. ABIN7490615

Quantity 100 μg

Datasheet Datasheet

MPL Protein

Reactivity Human

Source Wheat germ

Validations

Cat. No. ABIN1330315

Quantity 10 μg

Datasheet Datasheet

MPL Protein (AA 311-460) (His tag)

Reactivity Human

Source Escherichia coli (E. coli)

Validations

Cat. No. ABIN7406458

Quantity 100 μg

Datasheet Datasheet

Aliases for MPL Proteins

MPL proto-oncogene, thrombopoietin receptor (MPL) Proteins
myeloproliferative leukemia virus oncogene (Mpl) Proteins
MPL proto-oncogene, thrombopoietin receptor (Mpl) Proteins
MPL proto-oncogene, thrombopoietin receptor (mpl) Proteins
C-MPL Proteins
c-mpl Proteins
c-mpl-I Proteins
c-mpl-II Proteins
CD110 Proteins
hlb219 Proteins
MPL Proteins
mpll Proteins
MPLV Proteins
THCYT2 Proteins
TPO-R Proteins
TPOR Proteins
tpor Proteins
tpor.b Proteins

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MPL Proteins by Grade

MPL Proteins by Origin

MPL Proteins by Source

MPL Proteins by Protein Type

MPL Proteins by Application

Popular MPL Proteins

Aliases for MPL Proteins

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