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These results illustrate promising antitumor activity against PRLR-positive breast cancer xenografts and support the evaluation of anti-PRLR antibody-drug conjugate as potential therapeutic agents in breast cancer.
Prl (show PRL Proteins) receptor is expressed at different levels in the majority of glioblastoma multiforme tumors. Prolactin (show PRL Proteins) stimulation resulted in increased STAT5 (show STAT5A Proteins) phosphorylation and increased cellular invasion.
This study identified 4 PRLR variations (p.Ile76Val, p.Ile146Leu, p.Glu108Lys and p.Glu554Gln) in 16 Sporadic Prolactinoma in Humans.
results highlight PRLR as an independent predictor of favorable prognosis in human breast cancer
Two markers for the PRL (show PRL Proteins) peptide gene and three markers for the prolactin receptor (PRLR) gene were genotyped.
The prolactin receptor is constitutively expressed on regulatory T and effector T cells in systemic lupus erythematosus patients, and this expression is higher than in healthy individuals.
There is a possible role for PRLR in the progression of cervical cancer.
PRL (show PRL Proteins)-PRLR can escalate the impact of breast cancer on bone metastasis and the presence of PRLR in the tumor microenvironment of breast cancer bone metastasis has the potential to modulate the microenvironment to induce lytic osteoclast formation.
Study shows that position 146 plays a central role in directing intrinsic properties of the PRLR, including extracellular domain folding, PRL (show PRL Proteins)-responsiveness, and ligand-independent activity of the receptor.
Data suggest that (1) cell membrane/lipid bilayer binding of PRLR and (2) tyrosine phosphorylation of PRLR intracellular domain are independent.
The presence and localization of prolactin receptor are consistent with expression data reported for other species, and the presence of PIP (show PIP Proteins) and prolactin (show PRL Proteins) in seminal fluid is consistent with data generated in humans.
This study revealed for the first time that the PRLR gene is a promising candidate gene that affects growth traits in cattle.
determination of the effects of exposure to different lengths of daylight during the dry period on circulating PRL (show PRL Proteins) and PRL (show PRL Proteins) receptor mRNA expression in lymphocytes and mammary tissue during the transition to lactation
Alternative splicing of transcripts from nine first exons of the porcine PRLR (pPRLR) gene are differentially expressed in various tissues.
The effects of prolactin receptor and beta-casein (show CSN2 Proteins) genotype on the nutritive value of sow milk are reported.
PRLR was identified as down-regulated in the oviduct of immotile short tail sperm (ISTS) homozygous sows. The methylation pattern of the PRLR gene region appeared unaffected.
Associations between genotypes of the prolactin receptor (PRLR) gene and swine reproductive, growth and meat traits were determined.
A prolactin receptor short mRNA sequence that is encoded by exon 11 within the pPRLR gene is expressed most abundantly in several tissues known to be prolactin (show PRL Proteins) targets in pigs. The pPRLR-SF acts as a dominant negative to the pPRLR-LF.
Results showed that the effects of FSHb (show FSHB Proteins), ESR (show ESR1 Proteins), and PRLR genes were significant in the Tibet pig population, and the effective genotypes of the three genes for reproductive traits were BB, BB, and AA, respectively.
found associations between PRLR genotype and ejaculate volume, sperm concentration, percentage of live sperm, and number of live sperm in the ejaculate
A report of greater than expected levels of amino acid variability within the intracellular domain of the porcine PRLR, which have been associated with differences in ovulation in sows and the preweaning survivability of piglets is presented.
Data showed that sows with genotype AB in PRLR gene had a significantly higher frequency of lateral-lying-to- other-posture trait and percentage of sow-terminated nursing trait than sows with the AA and BB genotypes.
The results showed that the polymorphic sites of both PRLR and RBP4 (show RBP4 Proteins) genes are closely related to litter size traits.
both species had very similar patterns of PRL (show PRL Proteins) release and expression of PRLR mRNA, and no major differences were observed between turkey or chicken embryos
The estrogen-responsive pituitary hormone (show CGA Proteins) prolactin (PRL (show PRL Proteins)), through specific PRL (show PRL Proteins) receptor (PRLR), down-regulates hepatic triglyceride (TG) accumulation.
Truncating mutations of Prlr promote tumor growth in a model of human ERalpha (show ESR1 Proteins)+ breast cancer.
MafB (show MAFB Proteins) deletion in maternal beta-cells also produced GDM, with inadequate beta-cell expansion accompanied by failure to induce PRLR-dependent target genes regulating beta-cell proliferation. These results unveil molecular roles for PRLR signaling in orchestrating the physiologic expansion of maternal beta-cells during pregnancy.
Of the four placenta-specific, Prl (show PRL Proteins)-related hormones that have been shown to interact with the Prlr, their gene expression localizes to different endocrine cell types
Prolactin (show PRL Proteins) transport into mouse brain is independent of prolactin receptor.
Prolactin receptor was upregulated in proximal kidney tubule cells of mice with cardiac disease.
This study showed in knockout mice showed no effect of PRL (show PRL Proteins) and PRL-R gene ablation on heat and cold hyperalgesia in male mice, while heat hyperlgesia were reduced 3-72 h post-surgery in female PRL (show PRL Proteins) and PRL-R knockout mice
The in utero environment of the Prlr(+/-) mother confers long-term changes in the pancreatic islets of her offspring such that when the offspring themselves became pregnant, they cannot adapt to the increased insulin (show INS Proteins) demands of their own pregnancy.
results provide direct genetic evidence that PRLR affects energy balance and metabolic adaptation in rodents via effects on brown adipose tissue differentiation and function
Germline knockout of prolactin (show PRL Proteins) or its receptor has failed to reveal a key role for prolactin (show PRL Proteins) signaling in mouse prostate physiology.
PRL (show PRL Proteins) receptor signaling exerts robust effects on lactotroph development and plays a permissive role in lactotroph osmo-responsiveness
This gene encodes a receptor for the anterior pituitary hormone, prolactin, and belongs to the type I cytokine receptor family. Prolactin-dependent signaling occurs as the result of ligand-induced dimerization of the prolactin receptor. Several alternatively spliced transcript variants encoding different membrane-bound and soluble isoforms have been described for this gene, which may function to modulate the endocrine and autocrine effects of prolactin in normal tissue and cancer.
, hPRL receptor
, secreted prolactin binding protein
, prolactin receptor long form
, equates to base 1078-1204 of D13154
, prolactin receptor b
, prolactin receptor
, prolactin receptor-like
, lactogen receptor
, prolactin receptor related sequence 1