|Antigen||Serotonin Receptor 4 (HTR4) Antibodies|
|Reactivity||Human, Rat (Rattus), Mouse (Murine) Alternatives|
|Conjugate||This Serotonin Receptor 4 antibody is un-conjugated Alternatives|
Immunohistochemistry (IHC), Western Blotting (WB)
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Product Details anti-Serotonin Receptor 4 AntibodyTarget Details Serotonin Receptor 4 Application Details Handling Images
|Specificity||Specific for 5HT4R receptor.|
|Immunogen||A synthetic peptide from c-terminal region of human 5HT4 receptor conjugated to an immunogenic carrier protein was used as the antigen. The peptide is homologous in mouse and rat.|
Target Details Serotonin Receptor 4Product Details anti-Serotonin Receptor 4 Antibody Application Details Handling Images back to top
|Alternative Name||5HT4 R (HTR4 Antibody Abstract)|
Function: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.
Subcellular location: Cell membrane, Multi-pass membrane protein. Endosome. Note: Interaction with SNX27 mediates recruitment to early endosomes, while interaction with SLC9A3R1 and EZR might target the protein to specialized subcellular regions, such as microvilli.
Tissue specificity: Isoform 5-HT4(A) is expressed in ileum, brain, and atrium, but not in the ventricle. Also known as: 5-hydroxytryptamine receptor 4R, 5-HT4R, Serotonin receptor 4R, HTR4R.
|Pathways||JAK-STAT Signaling, cAMP Metabolic Process|
Application DetailsProduct Details anti-Serotonin Receptor 4 Antibody Target Details Serotonin Receptor 4 Handling Images back to top
A dilution of 1: 300 to 1: 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
|Restrictions||For Research Use only|
HandlingProduct Details anti-Serotonin Receptor 4 Antibody Target Details Serotonin Receptor 4 Application Details Images back to top
|Reconstitution||Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.|
|Handling Advice||Avoid freeze and thaw cycles.|
|Storage||4 °C/-20 °C|
|Storage Comment||Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.|
|Expiry Date||12 months|