anti-Dog (Canine) SOCS1 antibody for Immunohistochemistry

Recommended SOCS1 Antibody (supplied by: Log in to see )

Antigen
Suppressor of Cytokine Signaling 1 (SOCS1) Antibodies
  • socs1
  • zgc:91868
  • jab
  • cis1
  • ssi1
  • tip3
  • cish1
  • ssi-1
  • socs-1
  • SOCS1
  • LOC100228306
  • socs1b
  • CIS1
  • CISH1
  • JAB
  • SOCS-1
  • SSI-1
  • SSI1
  • TIP3
  • Cish1
  • Cish7
  • Socs-1
  • suppressor of cytokine signaling 1a
  • suppressor of cytokine signaling 1
  • suppressor of cytokine signaling 1 L homeolog
  • socs1a
  • socs1
  • SOCS1
  • socs1.L
  • Socs1
Epitope
N-Term
54
20
15
6
3
3
3
2
2
2
2
1
1
1
1
1
1
Reactivity
Cow (Bovine), Dog (Canine), Guinea Pig, Horse (Equine), Human, Mouse (Murine), Pig (Porcine), Rabbit, Rat (Rattus)
166
97
78
9
7
6
4
3
3
3
2
Host
Rabbit
150
19
11
Clonality
Polyclonal
Conjugate
This SOCS1 antibody is un-conjugated
11
7
6
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
154
62
49
30
15
13
11
8
6
6
5
2
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Catalog No. ABIN2777164
$ 229.00
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
9.312962 ABIN630223 IHC WB Rabbit N-Term Log in to see Polyclonal 0
1 ABIN2462535 IHC ELISA WB Rabbit Log in to see Polyclonal 0
1 ABIN2560058 IHC ELISA WB Goat IgG C-Term Log in to see Polyclonal 0

General

Antigen Suppressor of Cytokine Signaling 1 (SOCS1) Antibodies
Epitope N-Term
(54), (20), (15), (6), (3), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Reactivity Cow (Bovine), Dog (Canine), Guinea Pig, Horse (Equine), Human, Mouse (Murine), Pig (Porcine), Rabbit, Rat (Rattus)
(166), (97), (78), (9), (7), (6), (4), (3), (3), (3), (2)
Host Rabbit
(150), (19), (11)
Clonality
Polyclonal
Conjugate This SOCS1 antibody is un-conjugated
(11), (7), (6), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Immunohistochemistry (IHC), Western Blotting (WB)
(154), (62), (49), (30), (15), (13), (11), (8), (6), (6), (5), (2)
Pubmed 1 reference available
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Product Details anti-SOCS1 Antibody

Target Details SOCS1 Application Details Handling References for anti-SOCS1 antibody (ABIN2777164) Images
Sequence RRPEPSSSSS SSPAAPARPR PCPAVPAPAP GDTHFRTFRS HADYRRITRA
Predicted Reactivity Cow: 100%, Dog: 92%, Guinea Pig: 93%, Horse: 90%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%
Characteristics This is a rabbit polyclonal antibody against SOCS1. It was validated on Western Blot and immunohistochemistry.
Purification Protein A purified
Immunogen The immunogen is a synthetic peptide directed towards the N terminal region of human SOCS1
Plasmids, Primers & others

Target Details SOCS1

Product Details anti-SOCS1 Antibody Application Details Handling References for anti-SOCS1 antibody (ABIN2777164) Images back to top
Antigen
Alternative Name SOCS1 (SOCS1 Antibody Abstract)
Background SOCS1 is a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. SOCS1 functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of its gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival.This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival.
Alias Symbols: CIS1, CISH1, JAB, SOCS-1, SSI-1, SSI1, TIP3
Protein Interaction Partner: CSF2RB, TCEB1, ERBB2, ABL1, CYTIP, gag, TP53, JAK2, ATR, ATM, JAK1, INSR, FGFR3, LCK, RASA1, PDCD1, IRS1, ETV6, DAB1, TIRAP, VHL, VAV1, TUBG1, RELA, MAP3K5, CLEC7A, PTPN11, TYK2, IRF3, IFNAR1, TCEB2, ALK, COMMD1, TRIM8, PIK3R2, GHR, IRS2, TEC, NCK1, VAV2,
Protein Size: 211
Molecular Weight 23 kDa
Gene ID 8651
NCBI Accession NM_003745, NP_003736
UniProt O15524
Pathways JAK-STAT Signaling, Interferon-gamma Pathway, TLR Signaling, Response to Growth Hormone Stimulus

Application Details

Product Details anti-SOCS1 Antibody Target Details SOCS1 Handling References for anti-SOCS1 antibody (ABIN2777164) Images back to top
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 211 AA

Restrictions For Research Use only

Handling

Product Details anti-SOCS1 Antibody Target Details SOCS1 Application Details References for anti-SOCS1 antibody (ABIN2777164) Images back to top
Format Liquid
Concentration Lot specific
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-SOCS1 antibody (ABIN2777164)

Product Details anti-SOCS1 Antibody Target Details SOCS1 Application Details Handling Images back to top
Background publications

Melzner, Weniger, Bucur, Brüderlein, Dorsch, Hasel, Leithäuser, Ritz, Dyer, Barth, Möller: "Biallelic deletion within 16p13.13 including SOCS-1 in Karpas1106P mediastinal B-cell lymphoma line is associated with delayed degradation of JAK2 protein." in: International journal of cancer. Journal international du cancer, Vol. 118, Issue 8, pp. 1941-4, 2006

Images

Product Details anti-SOCS1 Antibody Target Details SOCS1 Application Details Handling References for anti-SOCS1 antibody (ABIN2777164) back to top
Supplier Images
Western Blotting (WB) image for anti-Suppressor of Cytokine Signaling 1 (SOCS1) (N-Term) antibody (ABIN2777164) WB Suggested Anti-SOCS1 Antibody Titration: 1.25ug/ml
Sample Type...
Western Blotting (WB) image for anti-Suppressor of Cytokine Signaling 1 (SOCS1) (N-Term) antibody (ABIN2777164) SOCS1 antibody - N-terminal region validated by WB using Jurkat cell lysate at 0.2-1...
 image for anti-Suppressor of Cytokine Signaling 1 (SOCS1) (N-Term) antibody (ABIN2777164) anti-Suppressor of Cytokine Signaling 1 (SOCS1) (N-Term) antibody (Image 3)
Western Blotting (WB) image for anti-Suppressor of Cytokine Signaling 1 (SOCS1) (N-Term) antibody (ABIN2777164) SOCS1 antibody - N-terminal region validated by WB using Huh7 Cells transfected with...
Western Blotting (WB) image for anti-Suppressor of Cytokine Signaling 1 (SOCS1) (N-Term) antibody (ABIN2777164) Host: Mouse Target Name: SOCS1 Sample Tissue: Mouse Pancreas Antibody Dilution:...
Western Blotting (WB) image for anti-Suppressor of Cytokine Signaling 1 (SOCS1) (N-Term) antibody (ABIN2777164) Lanes: 1. Mouse WT brain extract (80ug) 2. Rat brain extract (80ug) Primary Antibo...
Immunohistochemistry (IHC) image for anti-Suppressor of Cytokine Signaling 1 (SOCS1) (N-Term) antibody (ABIN2777164) Rabbit Anti-SOCS1 Antibody Paraffin Embedded Tissue: Human Kidney Cellular Data: Epi...