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|Antigen||Suppressor of Cytokine Signaling 4 (SOCS4) Antibodies|
|Conjugate||This SOCS4 antibody is un-conjugated Alternatives|
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Western Blotting (WB)
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Product Details anti-SOCS4 AntibodyTarget Details SOCS4 Application Details Handling Images
|Specificity||This antibody recognizes Suppressor of cytokine signaling 4 (SOCS4).|
|Cross-Reactivity (Details)||Species reactivity (tested):Human.|
|Immunogen||Synthetic peptide KLH conjugated from the C-terminus of Hman SOCS4. Genename: SOCS4|
Target Details SOCS4Product Details anti-SOCS4 Antibody Application Details Handling Images back to top
|Alternative Name||SOCS4 (SOCS4 Antibody Abstract)|
|Background||Accumulating evidence has demonstrated that cytokine receptor signaling is negatively regulated by a family of Src homology 2 domain-containing adaptor molecules termed SOCS (Suppressor of Cytokine Signaling) (1-3). Currently, there are eight members of the SOCS family that have been recognized, SOCS-1, -2, -3, -4, - 5, -6, -7 and CIS. Structurally, the SOCS proteins are composed of an N-terminus region of variable length and amino acid composition, a central SH2 domain, and a previously unrecognized C-terminus motif that has been called the SOCS box (4). The SOCS proteins appear to form part of a classical negative feed back loop that regulates cytokine signal transduction via a STATinduced transcriptional mechanism (5). Transcription of each of the SOCS genes occurs rapidly in vitro and in vivo in response to cytokines, and once produced, the various members of the SOCS family appear to inhibit signaling in different ways. Within the SOCS subfamily, SOCS-4, SOCS-5, SOCS-6, SOCS-7 remain poorly understood (6). On the basis of structural considerations, it would be expected that SOCS-4, -5, -6, and -7, like SOCS-1, SOCS-2, SOCS-3 and CIS, act to negatively regulate signal transduction (4), but it is uncertain which specific cytokine is involved (7-9).Synonyms: SOCS-4, SOCS-7, SOCS7, Suppressor of cytokine signaling 4, Suppressor of cytokine signaling 7|
|Pathways||JAK-STAT Signaling, EGFR Signaling Pathway|
Application DetailsProduct Details anti-SOCS4 Antibody Target Details SOCS4 Handling Images back to top
Immunoprecipitation: 3-5 ng/IE6 cells. Western Blot: 0.5-2 μg/mL. Immunohistochemistry on Paraffin Sections: 10 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-SOCS4 Antibody Target Details SOCS4 Application Details Images back to top
|Buffer||PBS, pH 7.4, 0.05 % Soduim Azide|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||DO NOT FREEZE!!|
|Storage Comment||Store the antibody undiluted at 2-8 °C.|
ImagesProduct Details anti-SOCS4 Antibody Target Details SOCS4 Application Details Handling back to top