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|Antigen||Suppressor of Cytokine Signaling 5 (SOCS5) Antibodies|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This SOCS5 antibody is conjugated to HRP Alternatives|
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
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Product Details anti-SOCS5 AntibodyTarget Details SOCS5 Application Details Handling Images
|Purification||Purified by Protein A.|
|Immunogen||KLH conjugated synthetic peptide derived from human SOCS5|
Target Details SOCS5Product Details anti-SOCS5 Antibody Application Details Handling Images back to top
|Alternative Name||Socs5 (SOCS5 Antibody Abstract)|
The eight members of the recently identified Suppressor of Cytokines Signaling (SOCS) family are SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS6, SOCS7, and CIS. Structurally the SOCS proteins are composed of an N- terminal region of variable length and amino acid composition, a central SH2 domain, and a C-terminal motif called the SOCS box. The SOCS proteins appear to form part of a classical negative feedback loop that regulates cytokine signal transduction. Transcription of each of the SOCS genes occurs rapidly in vitro and in vivo in response to cytokines, and once produced, the various members of the SOCS family appear to inhibit signaling in different ways. During Th1 differentiation a reduction in the association of Jak1 with the IL4 Receptor correlated with the appearance of SOCS5. SOCS5 protein was preferentially expressed in committed Th1 cells and interacted with the cytoplasmic region of the IL4 Receptor alpha chain irrespective of receptor tyrosine phosphorylation. This unconventional interaction of SOCS5 protein with IL4 Receptor resulted in the inhibition of IL4-mediated signal transducer and activator of transcription-6 activation. T cells from transgenic mice constitutively expressing SOCS5 exhibited a significant reduction of IL4-mediated Th2 development. Therefore, the induced SOCS5 protein in Th1 differentiation environment may play an important role by regulating Th1 and Th2 balance.
Synonyms: CIS-6, CIS6, CISH5, CISH6, Cytokine inducible SH2 containing protein 5, Cytokine inducible SH2 protein 6, KIAA0671, SOCS-5, Suppressor of cytokine signaling 5.
|Pathways||JAK-STAT Signaling, EGFR Signaling Pathway, Positive Regulation of Immune Effector Process|
Application DetailsProduct Details anti-SOCS5 Antibody Target Details SOCS5 Handling Images back to top
|Restrictions||For Research Use only|
HandlingProduct Details anti-SOCS5 Antibody Target Details SOCS5 Application Details Images back to top
|Buffer||Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % Gentamicin.|
|Precaution of Use||This product contains Gentamicin sulfate: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.|
|Storage Comment||Store at 4°C|
|Expiry Date||12 months|