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Here the authors show that suppressor of cytokine signaling (SOCS (show CISH Proteins)) five has a pivotal role in restricting influenza A virus in the airway epithelium, through the regulation of epidermal growth factor receptor (EGFR (show EGFR Proteins)).
This study showed that SOCS5 expression was significantly down-regulated.
Opisthorchis felineus infection diminishes the risk of atopic bronchial asthma associated with the SOCS5 gene polymorphism.
different domains in SOCS5 contribute to two distinct mechanisms for regulation of cytokine and growth factor signaling with JAK1 (show JAK1 Proteins) and SHC-1 (show SHC1 Proteins)
The rs6737848 SOCS5 polymorphism was significantly associated with asthma in additive model and in dominant model
Exogenous miR (show MLXIP Proteins)-9 effectively reduced SOCS5 levels, leading to activated JAK (show JAK3 Proteins)-STAT (show STAT1 Proteins) pathway, which promoted endothelial cell migration and tumour angiogenesis
Identified is a conserved region of about 70 residues in the N-terminal domains of SOCS4 (show SOCS6 Proteins) and 5 that is predicted to be more ordered than the surrounding sequence.
The results may contribute to understanding SOCS5 and SOCS6 (show SOCS6 Proteins) expression regulation in various cancer tissues, and show that these two factors may be used for diagnosing cancer.
Up regulation of SOCS1 (show SOCS1 Proteins) and SOCS5 expression and down-regulation of SOCS3 (show SOCS3 Proteins) and CIS (show CISH Proteins) may correlate with the development of a Th1 (show TH1L Proteins) mediated immune response in Vogt-Koyanagi-Harada disease.
The reduction in EGFR (show EGFR Proteins) levels and EGF (show EGF Proteins)-induced signaling in SOCS5-expressing cells requires both the Src (show SRC Proteins) homology-2 and SOCS (show CISH Proteins) box domains of SOCS5.
this study shows that DRD3 (show DRD3 Proteins) signaling evokes Socs5 expression, a negative regulator of Th2 development, which indirectly favors acquisition of Th1 (show HAND1 Proteins) phenotype
have identified a phosphorylation site (Ser211) within the JIR of mSOCS5 and have investigated the role of phosphorylation in modulating JAK (show JAK3 Proteins) binding using site-directed mutagenesis.
Identified is a conserved region of about 70 residues in the N-terminal domains of Socs4 (show SOCS6 Proteins) and 5 that is predicted to be more ordered than the surrounding sequence.
The effect of Flt3 (show FLT3 Proteins)-L on Th17 cells and expression of suppressors of cytokine signaling (SOCS (show CISH Proteins)) proteins in the lungs of house dust mite (HDM (show HDAC3 Proteins))-sensitized and -challenged mice, was evaluated.
SOCS5 regulates Th1 (show HAND1 Proteins)/Th2 cell balance and suppresses IL-4 (show IL4 Proteins)
SOCS5-deficient CD4 (show CD4 Proteins) T cells showed no abnormalities in Th1 (show HAND1 Proteins)/Th2 differentiation and Socs5(-/-) mice showed normal resistance to infection with Leishmania major.
SOCS-5 associated with the EGF-R (show EGFR Proteins) complex in an EGF (show EGF Proteins)-independent manner
Adoptive transfer of SOCS5Tg-CD4 (show CD4 Proteins)+ T cells into T- and B cell-deficient RAG-2 (show RAG2 Proteins)(-/-) mice resulted in augmented leukocyte infiltration and increased peritoneal levels of IL-12 (show IL12A Proteins), IFN-gamma (show IFNG Proteins), and TNF-alpha (show TNF Proteins) after cecal ligation and puncture
The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS) family, also known as STAT-induced STAT inhibitor (SSI) protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The specific function of this protein has not yet been determined. Two alternatively spliced transcript variants encoding an identical protein have been reported.
suppressor of cytokine signaling 5
, suppressor of cytokine signaling 5-like
, cytokine-inducible SH2 protein 6
, cytokine-inducible SH2-containing protein 5
, cytokine inducible SH2-containing protein 5