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RANKL (show TNFSF11 Proteins) and Src has an unrecognized role in osteocyte survival.
These interactions are required for SRC-induced activation of VAV (show VAV1 Proteins) and the subsequent engagement of a JIP1 (show MAPK8IP1 Proteins)-tethered JNK (show MAPK8 Proteins) signaling module.
Elevated retinoic acid-inducible gene 1 (show RARRES3 Proteins) (RIG-I (show DDX58 Proteins)) modulated the interaction of activated proto-oncogene c-Src (Src) and STAT3 (show STAT3 Proteins) by competitive binding to STAT3 (show STAT3 Proteins).
Cbl, Cbl-b, and Cbl-c have a role in protecting mammary epithelial cellsfrom proteotoxic stress-induced cell death by promoting turnover of active c-Src
unlike c-fos-/- mice, c-src-/- mice demonstrated activated, mature osteoblasts, and parallel layers of cement lines in the superficial bone matrix, indicating the new bones were piled up to older bone.
TM, especially TME45, maintains vascular integrity, at least in part, via Src signaling.
We conclude that pp60(Src) can directly inhibit DDAH (show DDAH2 Proteins) II and this is involved in the increased ADMA levels that enhance eNOS (show NOS3 Proteins) uncoupling during the development of acute lung injury (ALI).
Ambra1 (show AMBRA1 Proteins) binds to both FAK (show PTK2 Proteins) and Src in cancer cells. When FAK (show PTK2 Proteins) is present, Ambra1 (show AMBRA1 Proteins) is recruited to focal adhesions, promoting FAK (show PTK2 Proteins)-regulated cancer cell direction-sensing and invasion. However, when Ambra1 (show AMBRA1 Proteins) cannot bind to FAK (show PTK2 Proteins), abnormally high levels of phospho-Src and phospho-FAK (show PTK2 Proteins) accumulate at focal adhesions, positively regulating adhesion and invasive migration.
Thus we propose that Cx43 (show GJA1 Proteins) might enhance the activation of Nrf2 (show NFE2L2 Proteins)/ARE pathway by means of inhibiting c-Src activity to hinder the nuclear export of Nrf2 (show NFE2L2 Proteins), and then reduce expression of FN, ICAM-1 (show ICAM1 Proteins) and TGF-b1, ultimately attenuating renal fibrosis in diabetes.
Osteoprotegerin (show TNFRSF11B Proteins) may induce podosome reassembly and peripheral adhesive structure detachment by modulating phosphorylation of Pyk2 (show PTK2B Proteins) and Src and their intracellular distribution in osteoclasts.
Src64 controls actin dynamics to mediate proper ring canal formation during incomplete cytokinesis during germline cyst development in vivo
that Brat represses the translation of src64B, an upstream regulator of a conserved Rho-dependent pathway previously shown to promote axon retraction
Results show that Src42a and Src64b are required for the normal division capacity of Drosophila intestinal progenitor cells, and that these genes as well as Ack cause progenitor overproliferation in the intestine via core cell cycle activation.
a novel essential role for Src in intestinal stem/progenitor cell proliferation and tumourigenesis initiation in vivo.
Data show that the actin-Capping Protein (show TMOD4 Proteins) (CP) alphabeta heterodimer, which regulates actin (show ACTB Proteins) filament (F-actin (show ACTB Proteins)) polymerization, limits Src-induced apoptosis or tissue overgrowth by restricting JNK (show MAPK8 Proteins) activation.
Dumbfounded/Neph1 (show NEPH1 Proteins), a key diaphragm constituent, is a target of the Src kinase (show CSK Proteins) Src64B. Loss of Src64B activity leads to a reduction in the number of diaphragms, and this effect is in part mediated by loss of Dumbfounded/Neph1 (show NEPH1 Proteins) tyrosine phosphorylation.
Homodimerization of the Wnt receptor DERAILED recruits the Src family kinase SRC64B in the developing embryonic central nervous system.
E4orf4 has a role in inducing PP2A (show PPP2R2B Proteins)- and Src-dependent cell death while inhibiting classic apoptosis pathways in Drosophila melanogaster
Mutations in a Drosophila src gene, src64, that alter the three HRD amino acids, were identified.
Src64B overexpression induced the formation of specialized haemocytes (lamellocytes), but had no effect on circulating plasmatocyte concentration. Src64B overexpression induced F-actin (show ACTB Proteins) formation and Jun kinase (show MAPK9 Proteins) activation in plasmatocytes.
Results suggest that Src promotes EGF (show EGF Proteins)-stimulated EMT (show ITK Proteins) and migration by upregulation of ZEB1 and ZEB2 (show ZEB2 Proteins) through AKT (show AKT1 Proteins) signaling pathway in gastric cancer cells.
Combined targeting of AKT (show AKT1 Proteins) and SRC resulted in a synergistic efficacy against human pancreatic cancer growth and metastasis.
important roles for c-Src tyrosine kinase (show CSK Proteins) in phosphorylation and activation of SLC11A1 (show SLC11A1 Proteins) in macrophages
Our data suggest that targeting Src signaling may be an effective approach to the treatment of ALK-non-small cell lung cancer (NSCLC) with acquired resistance to ALK inhibitors.
Src kinase (show CSK Proteins) in chemo-naive human primary osteosarcoma cells is differentially activated.
This study demonstrates that simultaneous inhibition of c-Met and Src signaling in MD-MSCs triggers apoptosis and reveals vulnerable pathways that could be exploited to develop NF2 (show NF2 Proteins) therapies.
Syntenin (show SDCBP Proteins) mediates SRC function in exosomal cell-to-cell communication.
Endothelial cell-derived matrix promotes the metabolic functional maturation of hepatocyte via integrin-Src signaling.
The expression of Src under the influence of nilotinib, dasatinib, erlotinib, gefitinib and afatinib was studied in HPV-positive head and neck squamous cell carcinomas. Src expression was significantly increased by all tested tyrosine kinase (show TXK Proteins) inhibitors.
Multivariate Cox (show COX8A Proteins) regression analysis suggested that PTPRA (show PTPRA Proteins) expression was an independent prognostic factor in SCC (show CYP11A1 Proteins) patients. In the cellular models, PTPRA (show PTPRA Proteins) promotes SCC (show CYP11A1 Proteins) cell proliferation through modulating Src activation as well as cell cycle progression. In conclusion, higher PTPRA (show PTPRA Proteins) level was associated with worse prognosis of SCC (show CYP11A1 Proteins) patients and PTPRA (show PTPRA Proteins) could promote the cell cycle progression
RhoA (show RHOA Proteins) and membrane fluidity mediates the spatially polarized Src/FAK (show PTK2 Proteins) activation in response to shear stress.
AngII activates PKD via a mechanism involving Src family kinases and PKC, to underlie increased aldosterone production.
The Src gene possibly contributed to conducting association analysis and can be recognized as genetic marker in milk production traits and other performance for animal breeding and genetics.
src has a role in activation of 5'-AMP (show TMPRSS5 Proteins)-activated kinase during hypoxia-reoxygenation of bovine aortic endothelial cells
results indicate that integrin engagement disrupts VE-cadherin-containing adherens junctions via the activation of Src, but not Ras, possibly as a result of modulation of the actin network
These results suggest that TGF-beta1 (show TGFB1 Proteins)-induced monolayer permeability involves focal adhesion and cytoskeletal rearrangement through both FAK (show PTK2 Proteins)/Src-dependent and -independent pathways.
The findings are consistent with previous studies that indicate a link between Na,K-ATPase (show ATP1A1 Proteins) activity and SFK signaling.
Src kinase (show CSK Proteins) mediates hypoxia-induced caspase-1 (show CASP1 Proteins) activation in the cerebral cortex of newborn piglets
Expression of mutant alpha1 Na/K-ATPase (show ATP1A1 Proteins) defective in conformational transition attenuates Src-mediated signal transduction
20-HETE activates the Raf/MEK/ERK pathway in renal epithelial cells through an EGFR- and c-Src-dependent mechanism.
This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene.
proto-oncogene tyrosine-protein kinase SRC
, proto-oncogene tyrosine-protein kinase src
, neuronal proto-oncogene tyrosine-protein kinase Src
, proto-oncogene c-Src
, Src proto oncogene sequence
, mRNA-like ncRNA in embryogenesis 5
, proto-oncogene tyrosine-protein kinase Src
, protooncogene SRC, Rous sarcoma
, tyrosine kinase pp60c-src
, tyrosine-protein kinase SRC-1
, Rous sarcoma oncogene
, tyrosine protein kinase c-src
, tyrosine protein kinase pp60-c-src
, v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
, src oncogene
, v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
, non-tyrosine protein kinase