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Src kinase (show CSK Proteins) activation by nitric oxide promotes resistance to anoikis in tumor cell lines.
RANKL (show TNFSF11 Proteins) and Src has an unrecognized role in osteocyte survival.
These interactions are required for SRC-induced activation of VAV (show VAV1 Proteins) and the subsequent engagement of a JIP1 (show MAPK8IP1 Proteins)-tethered JNK (show MAPK8 Proteins) signaling module.
Elevated retinoic acid-inducible gene 1 (show RARRES3 Proteins) (RIG-I (show DDX58 Proteins)) modulated the interaction of activated proto-oncogene c-Src (Src) and STAT3 (show STAT3 Proteins) by competitive binding to STAT3 (show STAT3 Proteins).
Cbl, Cbl-b, and Cbl-c have a role in protecting mammary epithelial cellsfrom proteotoxic stress-induced cell death by promoting turnover of active c-Src
unlike c-fos-/- mice, c-src-/- mice demonstrated activated, mature osteoblasts, and parallel layers of cement lines in the superficial bone matrix, indicating the new bones were piled up to older bone.
TM, especially TME45, maintains vascular integrity, at least in part, via Src signaling.
We conclude that pp60(Src) can directly inhibit DDAH (show DDAH2 Proteins) II and this is involved in the increased ADMA levels that enhance eNOS (show NOS3 Proteins) uncoupling during the development of acute lung injury (ALI).
Ambra1 (show AMBRA1 Proteins) binds to both FAK (show PTK2 Proteins) and Src in cancer cells. When FAK (show PTK2 Proteins) is present, Ambra1 (show AMBRA1 Proteins) is recruited to focal adhesions, promoting FAK (show PTK2 Proteins)-regulated cancer cell direction-sensing and invasion. However, when Ambra1 (show AMBRA1 Proteins) cannot bind to FAK (show PTK2 Proteins), abnormally high levels of phospho-Src and phospho-FAK (show PTK2 Proteins) accumulate at focal adhesions, positively regulating adhesion and invasive migration.
Thus we propose that Cx43 (show GJA1 Proteins) might enhance the activation of Nrf2 (show NFE2L2 Proteins)/ARE pathway by means of inhibiting c-Src activity to hinder the nuclear export of Nrf2 (show NFE2L2 Proteins), and then reduce expression of FN, ICAM-1 (show ICAM1 Proteins) and TGF-b1, ultimately attenuating renal fibrosis in diabetes.
Src overexpression alone activated the Jun N-terminal Kinase (JNK (show MAPK8 Proteins)) signalling pathway to promote actin (show ACTB Proteins) cytoskeletal and cell polarity defects and drive apoptosis in in a whole epithelial tissue context in the Drosophila eye, whereas, in cooperation with RasACT, JNK (show MAPK8 Proteins) led to a loss of differentiation and an invasive phenotype.
Src64 controls actin dynamics to mediate proper ring canal formation during incomplete cytokinesis during germline cyst development in vivo
that Brat represses the translation of src64B, an upstream regulator of a conserved Rho-dependent pathway previously shown to promote axon retraction
Results show that Src42a and Src64b are required for the normal division capacity of Drosophila intestinal progenitor cells, and that these genes as well as Ack cause progenitor overproliferation in the intestine via core cell cycle activation.
a novel essential role for Src in intestinal stem/progenitor cell proliferation and tumourigenesis initiation in vivo.
Data show that the actin-Capping Protein (show TMOD4 Proteins) (CP) alphabeta heterodimer, which regulates actin (show ACTB Proteins) filament (F-actin (show ACTB Proteins)) polymerization, limits Src-induced apoptosis or tissue overgrowth by restricting JNK (show MAPK8 Proteins) activation.
Dumbfounded/Neph1 (show NEPH1 Proteins), a key diaphragm constituent, is a target of the Src kinase (show CSK Proteins) Src64B. Loss of Src64B activity leads to a reduction in the number of diaphragms, and this effect is in part mediated by loss of Dumbfounded/Neph1 (show NEPH1 Proteins) tyrosine phosphorylation.
Homodimerization of the Wnt receptor DERAILED recruits the Src family kinase SRC64B in the developing embryonic central nervous system.
E4orf4 has a role in inducing PP2A (show PPP2R2B Proteins)- and Src-dependent cell death while inhibiting classic apoptosis pathways in Drosophila melanogaster
Mutations in a Drosophila src gene, src64, that alter the three HRD amino acids, were identified.
This study shows that Leu33Pro polymorphism of integrin beta 3 (show ITGB3 Proteins) modulates platelet Src pY418 and focal adhesion kinase pY397 phosphorylation in response to abnormally high shear stress. Whereas physiological shear stress does not affect platelet signaling, abnormally high-shear stress considerably elevates Src and FAK (show PTK2 Proteins) phosphorylation in both Pro33 and Leu33 platelets.
High SRC expression is associated with lung adenocarcinoma.
While activation in c-Src is strictly controlled by ATP-binding and phosphorylation, the authors find that activating conformational transitions are spontaneously sampled in Hsp90 (show HSP90 Proteins)-dependent Src mutants.
High SRC expression is associated with gastric cancer cell migration.
Src kinase (show CSK Proteins) mediates UV-induced TRPV1 (show TRPV1 Proteins) trafficking into cell membrane in HaCaT keratinocytes.
Src and Aurora-A (show AURKA Proteins) interact upon Golgi ribbon fragmentation; Src phosphorylates Aurora-A (show AURKA Proteins) at tyrosine 148 and this specific phosphorylation is required for Aurora-A (show AURKA Proteins) localization at the centrosomes.
Study demonstrated that c-Src contributed to hypoxic microenvironment-rendered paclitaxel resistance in human epithelial ovarian cancer cells by G2/M phase arrest deterioration, and through c-Src suppression, FV-429 was capable of reversing the resistance by blocking c-Src/Stat3 (show STAT3 Proteins)/HIF-1alpha (show HIF1A Proteins) pathway.
Data demonstrated that the Src/Fn14 (show TNFRSF12A Proteins)/NF-kappaB (show NFKB1 Proteins) axis plays a critical role in NSCLC metastasis.
Results suggest that Src promotes EGF (show EGF Proteins)-stimulated EMT (show ITK Proteins) and migration by upregulation of ZEB1 and ZEB2 (show ZEB2 Proteins) through AKT (show AKT1 Proteins) signaling pathway in gastric cancer cells.
RhoA (show RHOA Proteins) and membrane fluidity mediates the spatially polarized Src/FAK (show PTK2 Proteins) activation in response to shear stress.
AngII activates PKD via a mechanism involving Src family kinases and PKC, to underlie increased aldosterone production.
The Src gene possibly contributed to conducting association analysis and can be recognized as genetic marker in milk production traits and other performance for animal breeding and genetics.
src has a role in activation of 5'-AMP (show TMPRSS5 Proteins)-activated kinase during hypoxia-reoxygenation of bovine aortic endothelial cells
results indicate that integrin engagement disrupts VE-cadherin-containing adherens junctions via the activation of Src, but not Ras, possibly as a result of modulation of the actin network
These results suggest that TGF-beta1 (show TGFB1 Proteins)-induced monolayer permeability involves focal adhesion and cytoskeletal rearrangement through both FAK (show PTK2 Proteins)/Src-dependent and -independent pathways.
The findings are consistent with previous studies that indicate a link between Na,K-ATPase (show ATP1A1 Proteins) activity and SFK signaling.
Src kinase (show CSK Proteins) mediates hypoxia-induced caspase-1 (show CASP1 Proteins) activation in the cerebral cortex of newborn piglets
Expression of mutant alpha1 Na/K-ATPase (show ATP1A1 Proteins) defective in conformational transition attenuates Src-mediated signal transduction
20-HETE activates the Raf/MEK/ERK pathway in renal epithelial cells through an EGFR- and c-Src-dependent mechanism.
This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene.
proto-oncogene tyrosine-protein kinase SRC
, proto-oncogene tyrosine-protein kinase src
, neuronal proto-oncogene tyrosine-protein kinase Src
, proto-oncogene c-Src
, Src proto oncogene sequence
, mRNA-like ncRNA in embryogenesis 5
, proto-oncogene tyrosine-protein kinase Src
, protooncogene SRC, Rous sarcoma
, tyrosine kinase pp60c-src
, tyrosine-protein kinase SRC-1
, Rous sarcoma oncogene
, tyrosine protein kinase c-src
, tyrosine protein kinase pp60-c-src
, v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
, src oncogene
, v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
, non-tyrosine protein kinase