anti-Mouse (Murine) STAT1 antibody for Immunofluorescence

Recommended STAT1 Antibody (supplied by: Log in to see )

Antigen
Signal Transducer and Activator of Transcription 1, 91kDa (STAT1) Antibodies
  • CANDF7
  • ISGF-3
  • STAT91
  • 2010005J02Rik
  • AA408197
  • XStat1
  • STAT4
  • DD6G4-4
  • STAT
  • STAT1
  • dZ182H3.3
  • si:by134g18.2
  • si:by51f19.1
  • si:dz182h3.3
  • si:dz199m19.1
  • si:dz73o4.2
  • signal transducer and activator of transcription 1
  • signal transducer and activator of transcription 1 L homeolog
  • signal transducer and activator of transcription 1, 91kDa
  • signal transducer and activator of transcription 4
  • STAT1
  • Stat1
  • stat1.L
  • stat4
Epitope
AA 1-194
107
82
61
27
23
21
19
16
15
14
13
9
8
6
5
5
5
5
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Chicken, Dog (Canine), Frog, Human, Mouse (Murine), Rat (Rattus)
613
297
242
42
27
26
26
23
18
15
13
11
9
5
4
3
3
3
2
2
2
1
1
Host
Mouse
396
205
20
15
3
3
1
Clonality
Monoclonal
Conjugate
This STAT1 antibody is un-conjugated
18
18
15
14
14
14
11
7
7
6
6
6
5
5
5
5
5
5
5
5
5
5
4
4
4
4
4
4
2
2
1
1
Application
Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
536
183
164
113
103
53
52
31
24
14
10
5
5
4
2
2
1
1
1
Options
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Pubmed
5 references available

Available images

Western Blotting (WB) image for anti-Signal Transducer and Activator of Transcription 1, 91kDa (STAT1) (AA 1-194) antibody (ABIN967759)
Immunofluorescence (IF) image for anti-Signal Transducer and Activator of Transcription 1, 91kDa (STAT1) (AA 1-194) antibody (ABIN967759)
image for anti-Signal Transducer and Activator of Transcription 1, 91kDa (STAT1) (AA 1-194) antibody (ABIN967759)
Western Blotting (WB) image for anti-Signal Transducer and Activator of Transcription 1, 91kDa (STAT1) (AA 1-194) antibody (ABIN967759)
Catalog No. ABIN967759
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Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
11.7403755 ABIN2705254 IC IF IP IHC WB Rabbit C-Term, pSer727 Log in to see Polyclonal 0
11.7403755 ABIN967758 IF IP IHC WB Mouse IgG1 AA 1-194 Log in to see 1-Stat1 5
11.7403755 ABIN1870637 IF IHC WB Rabbit IgG pSer727 Log in to see Polyclonal 0
11.7403755 ABIN968750 IF ICS IP WB Mouse IgG1 pTyr701 Log in to see 14-P 2
11.7403755 ABIN968751 IF ICS IP WB Mouse IgG1 pTyr701 Log in to see 14-P 2
11.7403755 ABIN968779 IF IP WB Mouse IgG2a pTyr701 Log in to see 4a 2
11.7403755 ABIN968780 IF IP WB Mouse IgG2a pTyr701 Log in to see 4a 2
11.7403755 ABIN2957762 IC IF IP IHC WB Rabbit C-Term, pTyr701 Log in to see Polyclonal 0
11.7403755 ABIN4356288 ICC IF IHC IHC (p) WB Rabbit IgG Log in to see Polyclonal 0
1 ABIN196892 IF IHC (p) WB Rabbit pSer727 Log in to see Polyclonal 4
1 ABIN5555267 EIA IF IP WB Rabbit IgG C-Term Log in to see Polyclonal 0
1 ABIN362170 IF IHC WB Rabbit IgG pSer727 Log in to see Polyclonal 5
1 ABIN303289 IF IHC (p) IP WB Rabbit C-Term Log in to see Polyclonal 0
1 ABIN2882786 IF IHC WB Rabbit IgG pSer727 Log in to see Polyclonal 0
1 ABIN218690 ICC FACS IF IP WB Rabbit IgG pTyr701 Log in to see Polyclonal 0
1 ABIN2628793 ICC IF IHC (p) IP WB Rabbit pSer727 Log in to see Polyclonal 0
1 ABIN1842362 IF IHC WB Rabbit IgG pSer727 Log in to see Polyclonal 0
1 ABIN4356277 ICC IF IHC IHC (p) WB Rabbit pSer727 Log in to see Polyclonal 0
1 ABIN4356294 ICC IF WB Rabbit IgG Center Log in to see Polyclonal 0
1 ABIN4905315 IF IP WB Mouse IgG Log in to see 0

General

Antigen Signal Transducer and Activator of Transcription 1, 91kDa (STAT1) Antibodies
Epitope AA 1-194
(107), (82), (61), (27), (23), (21), (19), (16), (15), (14), (13), (9), (8), (6), (5), (5), (5), (5), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Chicken, Dog (Canine), Frog, Human, Mouse (Murine), Rat (Rattus)
(613), (297), (242), (42), (27), (26), (26), (23), (18), (15), (13), (11), (9), (5), (4), (3), (3), (3), (2), (2), (2), (1), (1)
Host Mouse
(396), (205), (20), (15), (3), (3), (1)
Clonality (Clone)
Monoclonal   ( )
Conjugate This STAT1 antibody is un-conjugated
(18), (18), (15), (14), (14), (14), (11), (7), (7), (6), (6), (6), (5), (5), (5), (5), (5), (5), (5), (5), (5), (5), (4), (4), (4), (4), (4), (4), (2), (2), (1), (1)
Application Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
(536), (183), (164), (113), (103), (53), (52), (31), (24), (14), (10), (5), (5), (4), (2), (2), (1), (1), (1)
Pubmed 5 references available
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Product Details anti-STAT1 Antibody

Target Details STAT1 Application Details Handling References for anti-STAT1 antibody (ABIN967759) Images
Cross-Reactivity Chicken, Dog (Canine), Frog, Mouse (Murine), Rat (Rattus)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Immunogen Human Stat1 aa. 1-194
Clone 1-Stat1
Isotype IgG1

Target Details STAT1

Product Details anti-STAT1 Antibody Application Details Handling References for anti-STAT1 antibody (ABIN967759) Images back to top
Antigen
Alternative Name Stat1 (STAT1 Antibody Abstract)
Background Stat (Signal transducer and activators of transcription) proteins are critical mediators of the biologic activity of cytokines, including interleukins, interferons, erythropoietin, and growth factors. Ligand-receptor interaction leads to activation of constitutively associated JAK family kinases and subsequent recruitment/activation of Stat proteins by tyrosine phosphorylation. Active Stat proteins then move to the nucleus to promote transcription of cytokine-inducible genes. Seven Stat proteins have been cloned, each of which is differentially expressed and/or activated in a cytokine-specific and cell type-specific manner. Stat1 and Stat2 are components of the ISGF3 (Interferon-Stimulated Gene Factor 3) complex, which is the primary transcription activator induced by the binding of the interferon to a specific cell-surface receptor. Stat1 has two alternatively spliced isoforms, 91-kDa Stat1alpha and 84 kDa Stat1beta, Stat1alpha has 38 additional C-terminal amino acids. In response to the binding of IFNalpha, IFNgamma, EGF, PDGF, or CSF-1 to their respective receptors, the Stat1 subunits become tyrosine-phosphorylated at Y701, and the complex is translocated to the nucleus. This results in the formation of an active complex that includes the DNA-binding p48 subunit. This complex is responsible for modulating the transcription of the interferon-stimulated genes (ISGs). Thus, phosphorylation of Y701 in Stat1 occurs in response to growth factors and cytokines, and is essential for normal transcriptional activity of the ISGF3 complex. The 1/Stat1 monoclonal antibody recognizes the N-terminus of human Stat1 (both isoforms), regardless of phosphorylation status. This antibody is routinely tested by western blot analysis.
Molecular Weight 91/84 kDa
Pathways JAK-STAT Signaling, RTK Signaling, Interferon-gamma Pathway, Response to Growth Hormone Stimulus, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Endopeptidase Activity, Hepatitis C, CXCR4-mediated Signaling Events

Application Details

Product Details anti-STAT1 Antibody Target Details STAT1 Handling References for anti-STAT1 antibody (ABIN967759) Images back to top
Comment

Related Products: ABIN968533, ABIN967389
Restrictions For Research Use only

Handling

Product Details anti-STAT1 Antibody Target Details STAT1 Application Details References for anti-STAT1 antibody (ABIN967759) Images back to top
Format Liquid
Concentration 250 μg/mL
Buffer Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store undiluted at -20° C.

References for anti-STAT1 antibody (ABIN967759)

Product Details anti-STAT1 Antibody Target Details STAT1 Application Details Handling Images back to top
Product cited in:

Doan, Ali, Bernstein: "Tyrosine kinase activation by the angiotensin II receptor in the absence of calcium signaling." in: The Journal of biological chemistry, Vol. 276, Issue 24, pp. 20954-8, 2001

Dupuis, Dargemont, Fieschi, Thomassin, Rosenzweig, Harris, Holland, Schreiber, Casanova: "Impairment of mycobacterial but not viral immunity by a germline human STAT1 mutation." in: Science (New York, N.Y.), Vol. 293, Issue 5528, pp. 300-3, 2001

Dumoutier, Louahed, Renauld: "Cloning and characterization of IL-10-related T cell-derived inducible factor (IL-TIF), a novel cytokine structurally related to IL-10 and inducible by IL-9." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 164, Issue 4, pp. 1814-9, 2000

Sadowski, Shuai, Darnell, Gilman: "A common nuclear signal transduction pathway activated by growth factor and cytokine receptors." in: Science (New York, N.Y.), Vol. 261, Issue 5129, pp. 1739-44, 1993

Fu, Schindler, Improta, Aebersold, Darnell: "The proteins of ISGF-3, the interferon alpha-induced transcriptional activator, define a gene family involved in signal transduction." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, Issue 16, pp. 7840-3, 1992

Images

Product Details anti-STAT1 Antibody Target Details STAT1 Application Details Handling References for anti-STAT1 antibody (ABIN967759) back to top
Supplier Images
Western Blotting (WB) image for anti-Signal Transducer and Activator of Transcription 1, 91kDa (STAT1) (AA 1-194) antibody (ABIN967759) Western blot analysis of Stat1 on a A431 cell lysate. Lane 1: 1:250, lane 2: 1:500, l...
Immunofluorescence (IF) image for anti-Signal Transducer and Activator of Transcription 1, 91kDa (STAT1) (AA 1-194) antibody (ABIN967759) Immunofluorescent staining of human fibroblast cells.
image for anti-Signal Transducer and Activator of Transcription 1, 91kDa (STAT1) (AA 1-194) antibody (ABIN967759) anti-Signal Transducer and Activator of Transcription 1, 91kDa (STAT1) (AA 1-194) antibody (Image 3)
Western Blotting (WB) image for anti-Signal Transducer and Activator of Transcription 1, 91kDa (STAT1) (AA 1-194) antibody (ABIN967759) anti-Signal Transducer and Activator of Transcription 1, 91kDa (STAT1) (AA 1-194) antibody (Image 4)