anti-Monkey STAT2 antibody for Western Blotting

Recommended STAT2 Antibody (supplied by: Log in to see )

Antigen
Signal Transducer and Activator of Transcription 2, 113kDa (STAT2) Antibodies
  • wu:fj84d07
  • p113
  • stat2
  • 1600010G07Rik
  • AW496480
  • ISGF-3
  • P113
  • STAT113
  • signal transducer and activator of transcription 2
  • AGAP000099-PA
  • stat2
  • STAT2
  • Stat2
Epitope
C-Term, pSer734
46
34
18
17
15
15
13
11
11
9
8
7
7
7
6
5
5
4
4
3
3
3
3
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Monkey
258
99
82
9
3
3
2
2
2
2
1
Host
Rabbit
279
19
1
Clonality
Polyclonal
Conjugate
This STAT2 antibody is un-conjugated
12
10
9
6
6
6
3
3
3
3
3
2
2
2
2
2
2
1
1
1
1
1
Application
ELISA, Western Blotting (WB)
243
117
108
46
27
23
17
13
9
6
3
3
3
2
1
1
1
1
1
Options
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Catalog No. ABIN5596752
$ 583.50
Plus shipping costs $45.00 and $23.00 dry ice
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
7.8026066 ABIN2705257 IHC WB Rabbit C-Term, pTyr690 Log in to see Polyclonal 0
7.8026066 ABIN2972201 IHC WB KLH Rabbit IgG C-Term, pTyr690 Log in to see Polyclonal 0
7.8026066 ABIN2972501 IHC WB Rabbit C-Term Log in to see Polyclonal 0
1 ABIN3198330 IHC WB Rabbit C-Term Log in to see Polyclonal 0
1 ABIN602339 IHC WB Rabbit IgG Log in to see Polyclonal 0
1 ABIN2628802 WB Rabbit IgG AA 796-814 Log in to see Polyclonal 0
1 ABIN2744561 IHC IHC (p) WB Rabbit C-Term Log in to see Polyclonal 0
1 ABIN2628796 ELISA WB Rabbit pSer734 Log in to see Polyclonal 0
1 ABIN1938666 IP WB Rabbit IgG AA 801-851 Log in to see Polyclonal 0

General

Antigen Signal Transducer and Activator of Transcription 2, 113kDa (STAT2) Antibodies
Epitope C-Term, pSer734
(46), (34), (18), (17), (15), (15), (13), (11), (11), (9), (8), (7), (7), (7), (6), (5), (5), (4), (4), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human, Monkey
(258), (99), (82), (9), (3), (3), (2), (2), (2), (2), (1)
Host Rabbit
(279), (19), (1)
Clonality
Polyclonal
Conjugate This STAT2 antibody is un-conjugated
(12), (10), (9), (6), (6), (6), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1)
Application ELISA, Western Blotting (WB)
(243), (117), (108), (46), (27), (23), (17), (13), (9), (6), (3), (3), (3), (2), (1), (1), (1), (1), (1)
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Product Details anti-STAT2 Antibody

Target Details STAT2 Application Details Handling Images
Cross-Reactivity (Details) This antibody is specific for phosphorylated S734 human STAT2. A BLAST analysis was used to suggest cross-reactivity with STAT2 pS734 protein from human and monkey sources based on homology with the immunizing sequence. Reactivity against homologues from other sources is not known.
Purification STAT2 pS734 affinity purified antibody is directed against human STAT2 protein. The product was affinity purified from monospecific antiserum by immunoaffinity chromatography.
Immunogen

Immunogen: STAT2 pS734 antibody was prepared from whole rabbit serum produced by repeated immunizations with a phosphorylated synthetic peptide corresponding to serine 734 a region near the C-terminus of human STAT2 protein.

Immunogen Type: Peptide

Isotype IgG
Plasmids, Primers & others

Target Details STAT2

Product Details anti-STAT2 Antibody Application Details Handling Images back to top
Antigen
Alternative Name STAT2 (STAT2 Antibody Abstract)
Background

Synonyms: Signal transducer and activator of transcription 2, p113, STAT2 antibody

Background: STAT2 is a member of the STAT family of transcription factors. Unlike other STATs, STAT2 is unique as it can only be activated by interferons (IFNs). STAT2 is a critical component in mediating many IFN-stimulated biological activities including antiproliferation and antiviral responses. Upon IFN treatment, STAT1 and STAT2 become tyrosine phosphorylated, assemble as heterodimers that bind IRF9 to form the ISGF3 complex. This complex translocates to the nucleus, binds to promoters of IFN-stimulated genes and mediates gene transcription. Consequently, mutations in STAT2 or loss of STAT2 expression leads to impairment in IFN signal transduction and gene activation. IFN-alpha is an approved drug for the treatment of several forms of cancer. Yet only a subset of patients who receive IFN-alpha therapy benefit from the treatment. Given that STAT2 is activated by IFNs, it is important to define if the reduced or lack of antitumor effects seen in cancer patients on IFN therapy is due to in defects in STAT2 function. STAT2 pS734 antibody is ideal for researchers focused in cancer and transcripton factor research.

Gene Name: STAT2

UniProt P52630
Pathways JAK-STAT Signaling, Hepatitis C, CXCR4-mediated Signaling Events

Application Details

Product Details anti-STAT2 Antibody Target Details STAT2 Handling Images back to top
Application Notes

Application Note: Anti-STAT2 pS734 antibody has been tested for use in ELISA and western blotting. Specific conditions for reactivity should be optimized by the end user. Expect a band approximately 97.9 kDa in size corresponding to STAT2pS734 protein by western blotting in the appropriate cell lysate or extract.

Western Blot Dilution: 1:1,000

ELISA Dilution: 1:5,000

Restrictions For Research Use only

Handling

Product Details anti-STAT2 Antibody Target Details STAT2 Application Details Images back to top
Format Liquid
Concentration 0.64 mg/mL
Buffer

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Stabilizer: None

Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C,-20 °C
Storage Comment Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
Expiry Date 12 months

Images

Product Details anti-STAT2 Antibody Target Details STAT2 Application Details Handling back to top
Supplier Images
Western Blotting (WB) image for anti-Signal Transducer and Activator of Transcription 2, 113kDa (STAT2) (C-Term), (pSer734) antibody (ABIN5596752) Western Blot of Rabbit anti-STAT2pS734 antibody. Lane 1: U6A cells (STAT2 deficient) ...