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|Antigen||Signal Transducer and Activator of Transcription 2, 113kDa (STAT2) Antibodies|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This STAT2 antibody is un-conjugated Alternatives|
Western Blotting (WB)
|Supplier||Log in to see|
Product Details anti-STAT2 AntibodyTarget Details STAT2 Application Details Handling Images
|Blocking Peptide||Blocking peptide for this product available: ABIN412918|
The antibody recognizes ~113 kDa of Stat2 from samples of human, mouse and rat origins.
Reactivity to other species has not been determined.
|Immunogen||Synthetic peptide surrounding amino acid 615 of rat Stat2|
Target Details STAT2Product Details anti-STAT2 Antibody Application Details Handling Images back to top
|Alternative Name||STAT2 (STAT2 Antibody Abstract)|
Membrane receptor signaling by various ligands induces activation of Jak kinases which then leads to tyrosine phosphorylation of the various Stat transcription factors. Stat1 and Stat2 are induced by IFN-α and form a heterodimer which is part of the ISGF3 transcription factor complex. Althoμgh early reports indicate Stat3 activation by EGF and IL-6, it has been shown that Stat3β appears to be activated by both while Stat3α is activated by EGF, but not by IL-6. Highest expression of Stat4 is seen in testis and myeloid cells. IL-12 has been identified as an activator of Stat4. Stat5 is activated by prolactin and by IL-3. Stat6 is involved in IL-4 activated signaling pathways.
Synonyms: STAT2 , ISGF-3 , P113 , p113 , STAT113 , MGC59816
|Pathways||JAK-STAT Signaling, Hepatitis C, CXCR4-mediated Signaling Events|
Application DetailsProduct Details anti-STAT2 Antibody Target Details STAT2 Handling Images back to top
|Application Notes||Western blotting (0.5-4 μg/mL), However, the optimal concentrations should be determined individually. The antibody recognizes ~113 kDa of Stat2 from samples of human, mouse and rat origins. Reactivity to other species has not been determined.|
|Restrictions||For Research Use only|
HandlingProduct Details anti-STAT2 Antibody Target Details STAT2 Application Details Images back to top
|Buffer||100 μg (0.5 mg/mL) affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30 % glycerol, 0.5 % BSA, and 0.01 % thimerosal.|
|Precaution of Use||This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||The antibody solution should be gently mixed before use.|
|Storage Comment||For long-term storage, aliquot and freeze at -70 °C.|
|Expiry Date||12 months|
ImagesProduct Details anti-STAT2 Antibody Target Details STAT2 Application Details Handling back to top