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|Antigen||Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) Antibodies|
|Epitope||AA 685-725, pTyr705 Alternatives|
|Reactivity||Human, Mouse (Murine), Pig (Porcine), Rat (Rattus) Alternatives|
|Conjugate||This STAT3 antibody is un-conjugated Alternatives|
Flow Cytometry (FACS), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
|6 references available|
|Supplier||Log in to see|
Product Details anti-STAT3 AntibodyTarget Details STAT3 Application Details Handling References for anti-STAT3 antibody (ABIN732638) Images
|Purification||Purified by Protein A.|
|Immunogen||KLH conjugated synthetic phosphopeptide derived from human STAT3 around the phosphorylation site of Tyr705|
|Plasmids, Primers & others|
Target Details STAT3Product Details anti-STAT3 Antibody Application Details Handling References for anti-STAT3 antibody (ABIN732638) Images back to top
|Alternative Name||Stat3 (STAT3 Antibody Abstract)|
Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA. Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity. Plays an important role in host defense in methicillin-resistant S.aureus lung infection by regulating the expression of the antimicrobial lectin REG3G (By similarity).
Subcellular location: Cytoplasm, Nucleus
Synonyms: APRF, HIES, ADMIO, Signal transducer and activator of transcription 3, Acute-phase response factor, STAT3
|Pathways||JAK-STAT Signaling, RTK Signaling, Interferon-gamma Pathway, Neurotrophin Signaling Pathway, Dopaminergic Neurogenesis, Response to Growth Hormone Stimulus, Carbohydrate Homeostasis, Stem Cell Maintenance, Hepatitis C, Protein targeting to Nucleus, Feeding Behaviour, CXCR4-mediated Signaling Events, Signaling of Hepatocyte Growth Factor Receptor|
Application DetailsProduct Details anti-STAT3 Antibody Target Details STAT3 Handling References for anti-STAT3 antibody (ABIN732638) Images back to top
|Restrictions||For Research Use only|
HandlingProduct Details anti-STAT3 Antibody Target Details STAT3 Application Details References for anti-STAT3 antibody (ABIN732638) Images back to top
|Buffer||Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.|
|Storage Comment||Store at -20°C|
|Expiry Date||12 months|
References for anti-STAT3 antibody (ABIN732638)Product Details anti-STAT3 Antibody Target Details STAT3 Application Details Handling Images back to top
|Product cited in:||
Zhang, Zhang, Zuo, Wang, Zhang, Xu, Li, Chen: "JAK-STAT signaling regulation of chicken embryonic stem cell differentiation into male germ cells." in: In vitro cellular & developmental biology. Animal, Vol. 53, Issue 8, pp. 728-743, 2017 Method employed by authors: Western Blotting (WB) (Sample species: Chicken).
Gao, Wang, Sun, Li, Wang, Yi, Wang: "Morusin shows potent antitumor activity for human hepatocellular carcinoma in vitro and in vivo through apoptosis induction and angiogenesis inhibition." in: Drug design, development and therapy, Vol. 11, pp. 1789-1802, 2017 Method employed by authors: Western Blotting (WB) (Sample species: Human).
Lee, Lee, Kim, Kim, Yang, Jeong, Seong: "Radiation Inhibits Interleukin-12 Production via Inhibition of C-Rel through the Interleukin-6/ Signal Transducer and Activator of Transcription 3 Signaling Pathway in Dendritic Cells." in: PLoS ONE, Vol. 11, Issue 1, pp. e0146463, 2016 Method employed by authors: Western Blotting (WB), Western Blotting (WB) (Sample species: Mouse (Murine)).
Sur, Swier, Radwan, Agrawal: "Increased Expression of Phosphorylated Polo-Like Kinase 1 and Histone in Bypass Vein Graft and Coronary Arteries following Angioplasty." in: PLoS ONE, Vol. 11, Issue 1, pp. e0147937, 2016 Method employed by authors: Immunofluorescence (Paraffin-embedded Sections) (IF (p)) (Sample species: Pig (Porcine)). Further details: Sample: heart
Iriyama, Hatta, Takei: "Direct effect of dasatinib on signal transduction pathways associated with a rapid mobilization of cytotoxic lymphocytes." in: Cancer medicine, Vol. 5, Issue 11, pp. 3223-3234, 2016
Yang, Sun, Sun, Qi: "Effect of suppressor of cytokine signaling 2 (SOCS2) on fat metabolism induced by growth hormone (GH) in porcine primary adipocyte." in: Molecular biology reports, Vol. 39, Issue 9, pp. 9113-22, 2012 Method employed by authors: Western Blotting (WB) (Sample species: Pig (Porcine)).
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