anti-Rat (Rattus) STAT3 antibody for Immunoprecipitation

Recommended STAT3 Antibody (supplied by: Log in to see )

Antigen
Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) Antibodies
  • 1110034C02Rik
  • AW109958
  • Aprf
  • APRF
  • HIES
  • Xstat3
  • aprf
  • hies
  • stat3
  • wu:fc15d02
  • wu:fl59g06
  • z-Stat3
  • signal transducer and activator of transcription 3
  • signal transduction and activation of transcription 3
  • signal transducer and activator of transcription 3, gene 1 L homeolog
  • signal transducer and activator of transcription 3 (acute-phase response factor)
  • STAT3
  • stat3
  • Stat3
  • stat3.1.L
Epitope
pSer727
128
101
71
18
16
15
15
14
12
10
7
7
5
5
5
5
4
4
4
4
4
4
4
4
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
628
361
286
42
39
32
31
14
11
10
7
7
5
5
4
3
3
1
1
1
1
1
Host
Rabbit
499
132
35
4
2
1
Clonality
Polyclonal
Conjugate
This STAT3 antibody is un-conjugated
27
23
19
15
12
11
7
5
3
3
3
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
Application
ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blotting (WB)
586
284
254
102
98
91
56
55
27
24
12
10
9
8
5
5
3
3
2
2
1
1
1
1
1
1
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Catalog No. ABIN6256411
$ 390.77
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
23.5 ABIN6255995 ELISA ICC IF IHC IP WB Rabbit IgG pTyr705 Log in to see Polyclonal 3
23.5 ABIN4898974 FACS ICC IP WB Mouse IgG2b AA 1-175 Log in to see 232209 4
18.75568 ABIN3182150 ELISA IHC IP WB Rabbit IgG pTyr705 Log in to see Polyclonal 0
18.75568 ABIN3182149 ELISA IHC IP WB Rabbit IgG pSer727 Log in to see Polyclonal 0
14.5 ABIN6255996 ELISA ICC IF IHC IP WB Rabbit IgG pTyr705 Log in to see Polyclonal 2
12.755681 ABIN1690457 IP Sepharose Rabbit Log in to see Polyclonal 0
12.755681 ABIN1690109 IP Magnetic Particles Rabbit Log in to see Polyclonal 0
10 ABIN2705260 IC IF IP IHC WB Rabbit C-Term Log in to see Polyclonal 0
10 ABIN2970895 IF/ICC IHC IP WB Rabbit Log in to see Polyclonal 0
10 ABIN2911391 IF/ICC IHC IP WB Rabbit AA 656-768 Log in to see Polyclonal 0
10 ABIN1847534 IP IHC ELISA WB Rabbit pTyr705 Log in to see Polyclonal 0
7 ABIN2705261 IP IHC WB Rabbit C-Term, pTyr705 Log in to see Polyclonal 0
7 ABIN2705258 IP IHC WB Rabbit C-Term, pSer727 Log in to see Polyclonal 0
7 ABIN1531975 ELISA IHC IP WB Rabbit IgG AA 694-743, pSer727 Log in to see Polyclonal 1
7 ABIN2888531 ELISA IHC IHC (p) IP WB Rabbit IgG pTyr705 Log in to see Polyclonal 0
7 ABIN2888530 ELISA IHC IHC (p) IP WB Rabbit IgG pSer727 Log in to see Polyclonal 0
7 ABIN318127 IHC (p) IP WB Rabbit pTyr705 Log in to see Polyclonal 0
7 ABIN318126 IHC (p) IP WB Rabbit pSer727 Log in to see Polyclonal 0
4 ABIN1804660 IHC IHC (p) IP WB Rabbit C-Term Log in to see Polyclonal 0
4 ABIN1845653 IP IHC WB Rabbit pSer727 Log in to see Polyclonal 0

General

Antigen Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) Antibodies
Epitope pSer727
(128), (101), (71), (18), (16), (15), (15), (14), (12), (10), (7), (7), (5), (5), (5), (5), (4), (4), (4), (4), (4), (4), (4), (4), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human, Mouse (Murine), Rat (Rattus)
(628), (361), (286), (42), (39), (32), (31), (14), (11), (10), (7), (7), (5), (5), (4), (3), (3), (1), (1), (1), (1), (1)
Host Rabbit
(499), (132), (35), (4), (2), (1)
Clonality
Polyclonal
Conjugate This STAT3 antibody is un-conjugated
(27), (23), (19), (15), (12), (11), (7), (5), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blotting (WB)
(586), (284), (254), (102), (98), (91), (56), (55), (27), (24), (12), (10), (9), (8), (5), (5), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1)
Pubmed 3 references available
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Product Details anti-STAT3 Antibody

Target Details STAT3 Application Details Handling References for anti-STAT3 antibody (ABIN6256411) Images
Specificity Phospho-STAT3 (Ser727) Antibody detects endogenous levels of STAT3 only when phosphorylated at Serine 727
Cross-Reactivity Human, Mouse (Murine), Rat (Rattus)
Purification The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Immunogen A synthesized peptide derived from human STAT3 around the phosphorylation site of Serine 727
Isotype IgG
Plasmids, Primers & others

Target Details STAT3

Product Details anti-STAT3 Antibody Application Details Handling References for anti-STAT3 antibody (ABIN6256411) Images back to top
Antigen
Alternative Name STAT3 (STAT3 Antibody Abstract)
Background

Description: Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors (PubMed:10688651, PubMed:12359225, PubMed:12873986, PubMed:15194700, PubMed:17344214, PubMed:18242580, PubMed:23084476). Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene (PubMed:17344214). May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:12873986). Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes (PubMed:12359225). Activated by IL31 through IL31RA (PubMed:15194700). Acts as a regulator of inflammatory response by regulating differentiation of naive CD4+ T-cells into T-helper Th17 or regulatory T-cells (Treg): deacetylation and oxidation of lysine residues by LOXL3, leads to disrupt STAT3 dimerization and inhibit its transcription activity (PubMed:28065600). Involved in cell cycle regulation by inducing the expression of key genes for the progression from G1 to S phase, such as CCND1 (PubMed:17344214). Mediates the effects of LEP on melanocortin production, body energy homeostasis and lactation (By similarity). May play an apoptotic role by transctivating BIRC5 expression under LEP activation (PubMed:18242580). Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity (PubMed:23084476). Plays a crucial role in basal beta cell functions, such as regulation of insulin secretion (By similarity).

Gene: STAT3

Molecular Weight 86kDa
Gene ID 6774
UniProt P40763
Pathways JAK-STAT Signaling, RTK Signaling, Interferon-gamma Pathway, Neurotrophin Signaling Pathway, Dopaminergic Neurogenesis, Response to Growth Hormone Stimulus, Carbohydrate Homeostasis, Stem Cell Maintenance, Hepatitis C, Protein targeting to Nucleus, Feeding Behaviour, CXCR4-mediated Signaling Events, Signaling of Hepatocyte Growth Factor Receptor

Application Details

Product Details anti-STAT3 Antibody Target Details STAT3 Handling References for anti-STAT3 antibody (ABIN6256411) Images back to top
Application Notes WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, IP 1:100-1:500
Restrictions For Research Use only

Handling

Product Details anti-STAT3 Antibody Target Details STAT3 Application Details References for anti-STAT3 antibody (ABIN6256411) Images back to top
Format Liquid
Concentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20 °C.Stable for 12 months from date of receipt
Expiry Date 12 months

References for anti-STAT3 antibody (ABIN6256411)

Product Details anti-STAT3 Antibody Target Details STAT3 Application Details Handling Images back to top
Product cited in:

Deng, Bu, Mo, Lv, Song, Xiao, Dan, Yang: "Huang Gan Formula Eliminates the Oxidative Stress Effects of Advanced Oxidation Protein Products on the Divergent Regulation of the Expression of AGEs Receptors via the JAK2/STAT3 Pathway." in: Evidence-based complementary and alternative medicine : eCAM, Vol. 2017, pp. 4520916, 2018

Chai, Bai, Li, Chen, Zhang: "Biological functions of lung cancer cells are suppressed in co-culture with mesenchymal stem cells isolated from umbilical cord." in: Experimental and therapeutic medicine, Vol. 15, Issue 1, pp. 1076-1080, 2018

Wang, Li, Chen, Yang: "Umbilical cord‑derived mesenchymal stem cells can inhibit the biological functions of melanoma A375 cells." in: Oncology reports, Vol. 40, Issue 1, pp. 511-517, 2018

Images

Product Details anti-STAT3 Antibody Target Details STAT3 Application Details Handling References for anti-STAT3 antibody (ABIN6256411) back to top
Supplier Images
Immunohistochemistry (IHC) image for anti-Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) (pSer727) antibody (ABIN6256411) ABIN6267503 at 1/200 staining Human lung cancer tissue sections by IHC-P. The tissue ...
Immunohistochemistry (IHC) image for anti-Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) (pSer727) antibody (ABIN6256411) ABIN6267503 at 1/200 staining Human pancreas tissue sections by IHC-P. The tissue was...
Immunohistochemistry (IHC) image for anti-Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) (pSer727) antibody (ABIN6256411) ABIN6267503 at 1/200 staining Human pancreas tissue sections by IHC-P. The tissue was...
Immunohistochemistry (IHC) image for anti-Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) (pSer727) antibody (ABIN6256411) ABIN6267503 at 1/200 staining Mouse brain tissue sections by IHC-P. The tissue was fo...
Immunohistochemistry (IHC) image for anti-Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) (pSer727) antibody (ABIN6256411) ABIN6267503 at 1/200 staining Rat lung tissue sections by IHC-P. The tissue was forma...
Western Blotting (WB) image for anti-Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) (pSer727) antibody (ABIN6256411) Western blot analysis of Phospho-STAT3 (Ser727) expression in Rat brain lysate
Western Blotting (WB) image for anti-Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) (pSer727) antibody (ABIN6256411) Western blot analysis of STAT3 phosphorylation expression in HeLa whole cell lysates,...
Immunofluorescence (fixed cells) (IF/ICC) image for anti-Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) (pSer727) antibody (ABIN6256411) ABIN6267503 staining A-431 cells by IF/ICC. The sample were fixed with PFA and permea...
Immunofluorescence (fixed cells) (IF/ICC) image for anti-Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) (pSer727) antibody (ABIN6256411) ABIN6267503 staining LOVO by IF/ICC. The sample were fixed with PFA and permeabilized...