anti-Rat (Rattus) STAT3 antibody for Immunoprecipitation
Recommended STAT3 Antibody (supplied by: Log in to see )
- Antigen
-
Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) Antibodies
show synonyms for this antigen- 1110034C02Rik
- AW109958
- Aprf
- APRF
- HIES
- Xstat3
- aprf
- hies
- stat3
- wu:fc15d02
- wu:fl59g06
- z-Stat3
- signal transducer and activator of transcription 3
- signal transduction and activation of transcription 3
- signal transducer and activator of transcription 3, gene 1 L homeolog
- signal transducer and activator of transcription 3 (acute-phase response factor)
- STAT3
- stat3
- Stat3
- stat3.1.L
- Epitope
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pSer727
Alternatives - Reactivity
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Human, Mouse (Murine), Rat (Rattus)
Alternatives - Host
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Rabbit
Alternatives - Clonality
- Conjugate
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This STAT3 antibody is un-conjugated
Alternatives - Application
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ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blotting (WB)
Alternatives - Supplier
- Log in to see
- Supplier Product No.
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| Relevance Score | ABIN | Application | Conjugate | Host | Isotype | Epitope | Supplier | Clonality | References | Details |
|---|---|---|---|---|---|---|---|---|---|---|
| 23.5 | ABIN6255995 | ELISA ICC IF IHC IP WB | Rabbit | IgG | pTyr705 | Log in to see | Polyclonal | 3 | ||
| 23.5 | ABIN4898974 | FACS ICC IP WB | Mouse | IgG2b | AA 1-175 | Log in to see | 232209 | 4 | ||
| 18.75568 | ABIN3182150 | ELISA IHC IP WB | Rabbit | IgG | pTyr705 | Log in to see | Polyclonal | 0 | ||
| 18.75568 | ABIN3182149 | ELISA IHC IP WB | Rabbit | IgG | pSer727 | Log in to see | Polyclonal | 0 | ||
| 14.5 | ABIN6255996 | ELISA ICC IF IHC IP WB | Rabbit | IgG | pTyr705 | Log in to see | Polyclonal | 2 | ||
| 12.755681 | ABIN1690457 | IP | Sepharose | Rabbit | Log in to see | Polyclonal | 0 | |||
| 12.755681 | ABIN1690109 | IP | Magnetic Particles | Rabbit | Log in to see | Polyclonal | 0 | |||
| 10 | ABIN2705260 | IC IF IP IHC WB | Rabbit | C-Term | Log in to see | Polyclonal | 0 | |||
| 10 | ABIN2970895 | IF/ICC IHC IP WB | Rabbit | Log in to see | Polyclonal | 0 | ||||
| 10 | ABIN2911391 | IF/ICC IHC IP WB | Rabbit | AA 656-768 | Log in to see | Polyclonal | 0 | |||
| 10 | ABIN1847534 | IP IHC ELISA WB | Rabbit | pTyr705 | Log in to see | Polyclonal | 0 | |||
| 7 | ABIN2705261 | IP IHC WB | Rabbit | C-Term, pTyr705 | Log in to see | Polyclonal | 0 | |||
| 7 | ABIN2705258 | IP IHC WB | Rabbit | C-Term, pSer727 | Log in to see | Polyclonal | 0 | |||
| 7 | ABIN1531975 | ELISA IHC IP WB | Rabbit | IgG | AA 694-743, pSer727 | Log in to see | Polyclonal | 1 | ||
| 7 | ABIN2888531 | ELISA IHC IHC (p) IP WB | Rabbit | IgG | pTyr705 | Log in to see | Polyclonal | 0 | ||
| 7 | ABIN2888530 | ELISA IHC IHC (p) IP WB | Rabbit | IgG | pSer727 | Log in to see | Polyclonal | 0 | ||
| 7 | ABIN318127 | IHC (p) IP WB | Rabbit | pTyr705 | Log in to see | Polyclonal | 0 | |||
| 7 | ABIN318126 | IHC (p) IP WB | Rabbit | pSer727 | Log in to see | Polyclonal | 0 | |||
| 4 | ABIN1804660 | IHC IHC (p) IP WB | Rabbit | C-Term | Log in to see | Polyclonal | 0 | |||
| 4 | ABIN1845653 | IP IHC WB | Rabbit | pSer727 | Log in to see | Polyclonal | 0 |
General |
|
|---|---|
| Antigen | Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) Antibodies |
| Epitope | pSer727 Alternatives |
| Reactivity | Human, Mouse (Murine), Rat (Rattus) Alternatives |
| Host | Rabbit Alternatives |
| Clonality | |
| Conjugate | This STAT3 antibody is un-conjugated Alternatives |
| Application |
ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blotting (WB)
Alternatives
|
|
3 references available |
| Supplier | Log in to see |
Product Details anti-STAT3 AntibodyTarget Details STAT3 Application Details Handling References for anti-STAT3 antibody (ABIN6256411) Images |
|
| Specificity | Phospho-STAT3 (Ser727) Antibody detects endogenous levels of STAT3 only when phosphorylated at Serine 727 |
| Cross-Reactivity | Human, Mouse (Murine), Rat (Rattus) |
| Purification | The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns. |
| Immunogen | A synthesized peptide derived from human STAT3 around the phosphorylation site of Serine 727 |
| Isotype | IgG |
| Plasmids, Primers & others | |
Target Details STAT3Product Details anti-STAT3 Antibody Application Details Handling References for anti-STAT3 antibody (ABIN6256411) Images back to top |
|
| Antigen | |
| Alternative Name | STAT3 (STAT3 Antibody Abstract) |
| Background |
Description: Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors (PubMed:10688651, PubMed:12359225, PubMed:12873986, PubMed:15194700, PubMed:17344214, PubMed:18242580, PubMed:23084476). Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene (PubMed:17344214). May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:12873986). Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes (PubMed:12359225). Activated by IL31 through IL31RA (PubMed:15194700). Acts as a regulator of inflammatory response by regulating differentiation of naive CD4+ T-cells into T-helper Th17 or regulatory T-cells (Treg): deacetylation and oxidation of lysine residues by LOXL3, leads to disrupt STAT3 dimerization and inhibit its transcription activity (PubMed:28065600). Involved in cell cycle regulation by inducing the expression of key genes for the progression from G1 to S phase, such as CCND1 (PubMed:17344214). Mediates the effects of LEP on melanocortin production, body energy homeostasis and lactation (By similarity). May play an apoptotic role by transctivating BIRC5 expression under LEP activation (PubMed:18242580). Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity (PubMed:23084476). Plays a crucial role in basal beta cell functions, such as regulation of insulin secretion (By similarity). Gene: STAT3 |
| Molecular Weight | 86kDa |
| Gene ID | 6774 |
| UniProt | P40763 |
| Pathways | JAK-STAT Signaling, RTK Signaling, Interferon-gamma Pathway, Neurotrophin Signaling Pathway, Dopaminergic Neurogenesis, Response to Growth Hormone Stimulus, Carbohydrate Homeostasis, Stem Cell Maintenance, Hepatitis C, Protein targeting to Nucleus, Feeding Behaviour, CXCR4-mediated Signaling Events, Signaling of Hepatocyte Growth Factor Receptor |
Application DetailsProduct Details anti-STAT3 Antibody Target Details STAT3 Handling References for anti-STAT3 antibody (ABIN6256411) Images back to top |
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| Application Notes | WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, IP 1:100-1:500 |
| Restrictions | For Research Use only |
HandlingProduct Details anti-STAT3 Antibody Target Details STAT3 Application Details References for anti-STAT3 antibody (ABIN6256411) Images back to top |
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| Format | Liquid |
| Concentration | 1 mg/mL |
| Buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol. |
| Preservative | Sodium azide |
| Precaution of Use | This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only. |
| Storage | -20 °C |
| Storage Comment | Store at -20 °C.Stable for 12 months from date of receipt |
| Expiry Date | 12 months |
References for anti-STAT3 antibody (ABIN6256411)Product Details anti-STAT3 Antibody Target Details STAT3 Application Details Handling Images back to top |
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| Product cited in: |
Deng, Bu, Mo, Lv, Song, Xiao, Dan, Yang: "Huang Gan Formula Eliminates the Oxidative Stress Effects of Advanced Oxidation Protein Products on the Divergent Regulation of the Expression of AGEs Receptors via the JAK2/STAT3 Pathway." in: Evidence-based complementary and alternative medicine : eCAM, Vol. 2017, pp. 4520916, 2018 Chai, Bai, Li, Chen, Zhang: "Biological functions of lung cancer cells are suppressed in co-culture with mesenchymal stem cells isolated from umbilical cord." in: Experimental and therapeutic medicine, Vol. 15, Issue 1, pp. 1076-1080, 2018 Wang, Li, Chen, Yang: "Umbilical cord‑derived mesenchymal stem cells can inhibit the biological functions of melanoma A375 cells." in: Oncology reports, Vol. 40, Issue 1, pp. 511-517, 2018 |
ImagesProduct Details anti-STAT3 Antibody Target Details STAT3 Application Details Handling References for anti-STAT3 antibody (ABIN6256411) back to top |
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| Supplier Images |
ABIN6267503 at 1/200 staining Human lung cancer tissue sections by IHC-P. The tissue ...
ABIN6267503 at 1/200 staining Human pancreas tissue sections by IHC-P. The tissue was...
ABIN6267503 at 1/200 staining Human pancreas tissue sections by IHC-P. The tissue was...
ABIN6267503 at 1/200 staining Mouse brain tissue sections by IHC-P. The tissue was fo...
ABIN6267503 at 1/200 staining Rat lung tissue sections by IHC-P. The tissue was forma...
Western blot analysis of Phospho-STAT3 (Ser727) expression in Rat brain lysate
Western blot analysis of STAT3 phosphorylation expression in HeLa whole cell lysates,...
ABIN6267503 staining A-431 cells by IF/ICC. The sample were fixed with PFA and permea...
ABIN6267503 staining LOVO by IF/ICC. The sample were fixed with PFA and permeabilized...
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