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General |
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Antigen | Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) Antibodies |
Reactivity | Human, Mouse (Murine), Rat (Meriones) Alternatives |
Host | Rabbit Alternatives |
Clonality | |
Conjugate | This STAT3 antibody is un-conjugated Alternatives |
Application |
Western Blotting (WB)
Alternatives
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2 references available |
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Product Details anti-STAT3 AntibodyTarget Details STAT3 Application Details Handling References for anti-STAT3 antibody (ABIN2801938) Images |
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Isotype | IgG |
Target Details STAT3Product Details anti-STAT3 Antibody Application Details Handling References for anti-STAT3 antibody (ABIN2801938) Images back to top |
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Antigen | |
Alternative Name | STAT3 (STAT3 Antibody Abstract) |
Background |
Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)- responsive elements identified in the promoters of various acute- phase protein genes. Activated by IL31 through IL31RA. Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity. Plays an important role in host defense in methicillin-resistant S.aureus lung infection by regulating the expression of the antimicrobial lectin REG3G (By similarity). Synonyms: Signal transducer and activator of transcription 3, Acute-phase response factor, STAT3, APRF |
Molecular Weight | 88068 Da |
Gene ID | 6774 |
UniProt | P40763 |
Pathways | JAK-STAT Signaling, RTK Signaling, Interferon-gamma Pathway, Neurotrophin Signaling Pathway, Dopaminergic Neurogenesis, Response to Growth Hormone Stimulus, Carbohydrate Homeostasis, Stem Cell Maintenance, Hepatitis C, Protein targeting to Nucleus, Feeding Behaviour, CXCR4-mediated Signaling Events, Signaling of Hepatocyte Growth Factor Receptor |
Application DetailsProduct Details anti-STAT3 Antibody Target Details STAT3 Handling References for anti-STAT3 antibody (ABIN2801938) Images back to top |
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Application Notes | WB - 1:1000 |
Restrictions | For Research Use only |
HandlingProduct Details anti-STAT3 Antibody Target Details STAT3 Application Details References for anti-STAT3 antibody (ABIN2801938) Images back to top |
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Buffer | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02 % sodium azide and 50 % glycerol. |
Preservative | Sodium azide |
Precaution of Use | WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing. |
References for anti-STAT3 antibody (ABIN2801938)Product Details anti-STAT3 Antibody Target Details STAT3 Application Details Handling Images back to top |
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Background publications |
Ota, Suzuki, Nishikawa, Otsuki, Sugiyama, Irie, Wakamatsu, Hayashi, Sato, Nagai, Kimura, Makita, Sekine, Obayashi, Nishi, Shibahara, Tanaka, Ishii, Yamamoto, Saito, Kawai, Isono, Nakamura, Nagahari et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs. ..." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, 2003 |
Product cited in: |
Pietra, Bressan, Pezzotti, Serlupi-Crescenzi: "Highly conserved amino-acid sequence between murine STAT3 and a revised human STAT3 sequence." in: Gene, Vol. 213, Issue 1-2, pp. 119-24, 1998 |
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Supplier Images |