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|Antigen||Signal Transducer and Activator of Transcription 5A (STAT5A) Antibodies|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This STAT5A antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Western Blotting (WB)
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Product Details anti-STAT5A AntibodyTarget Details STAT5A Application Details Handling Images
|Specificity||This antibody is specific for Stat5 protein.|
Species reactivity (expected):Rat, Human.
Species reactivity (tested):Mouse.
|Characteristics||Concentration: 1.2 mg/mL (by UV absorbance at 280 nm)|
|Immunogen||Synthetic peptide corresponding to residues near the carboxy terminus of mouse Stat5alpha protein|
Target Details STAT5AProduct Details anti-STAT5A Antibody Application Details Handling Images back to top
|Alternative Name||STAT5 / STAT5A (STAT5A Antibody Abstract)|
|Background||Signal transducer and activator of transcription 5 (Stat5) belongs to a family of cytoplasmic transcription factors that can be activated (phosphorylated) by a cell surface receptor. Phosphorylation at Tyr694 is obligatory for Stat5 activation. Stat5 has two isoforms, Stat5alpha and Stat5beta. Aberrant Stat5 activation has been implicated in the pathogenesis of chronic myelogenous leukemia, prostate and breast cancer and tumor metastasis. Stat5 is localized in the cytoplasm and upon phosphorylation at Y694 is translocated to the nucleus.Synonyms: MGF, Mammary gland factor, STAT-5, STAT-5A, Signal transducer and activator of transcription 5A|
|Pathways||JAK-STAT Signaling, RTK Signaling, Response to Growth Hormone Stimulus, C21-Steroid Hormone Metabolic Process, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, CXCR4-mediated Signaling Events, Activated T Cell Proliferation|
Application DetailsProduct Details anti-STAT5A Antibody Target Details STAT5A Handling Images back to top
ELISA: 1/25,000. Western Blot: 1/500 - 1/2,000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-STAT5A Antibody Target Details STAT5A Application Details Images back to top
|Buffer||0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 containing 0.01 % (w/v) Sodium Azide|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|