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|Antigen||Signal Transducer and Activator of Transcription 5B (STAT5B) Antibodies|
|Conjugate||This STAT5B antibody is un-conjugated Alternatives|
Dot Blot (DB)
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Product Details anti-STAT5B AntibodyTarget Details STAT5B Application Details Handling Images
|Cross-Reactivity (Details)||Other species not studied.|
|Purification||Protein G affinity chromatography|
|Immunogen||STAT5 B antibody was raised in mouse using recombinant Signal Transducer And Activator Of Transcription 5 (Stat5 ),|
Target Details STAT5BProduct Details anti-STAT5B Antibody Application Details Handling Images back to top
|Alternative Name||STAT5B (STAT5B Antibody Abstract)|
|Background||The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL. Synonyms: Monoclonal STAT5B antibody, Anti-STAT5B antibody, Signal transducer and activator of transcription 5B antibody, STAT5 antibody.|
|Pathways||JAK-STAT Signaling, RTK Signaling, Response to Growth Hormone Stimulus, C21-Steroid Hormone Metabolic Process, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, CXCR4-mediated Signaling Events, Activated T Cell Proliferation|
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|Application Notes||Optimal conditions should be determined by the investigator.|
|Restrictions||For Research Use only|
HandlingProduct Details anti-STAT5B Antibody Target Details STAT5B Application Details Images back to top
|Buffer||STAT5 B antibody in PBS (3.0 mM KCl, 1.5 mM KH2 PO4 , 140 mM NaCl, 8.0 mM Na2 HPO4 (pH 7.4)) containing 1 % bovine serum albumin (BSA) and 0.05 % sodium azide (NaN3 ).|
|Precaution of Use||This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.|
Avoid repeated freeze/thaw cycles.
Dilute only prior to immediate use.
|Storage Comment||Store at 2-8 °C for up to one year. We recommend long term storage at -20 °C.|
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