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anti-Human TYK2 Antibodies:
anti-Mouse (Murine) TYK2 Antibodies:
anti-Rat (Rattus) TYK2 Antibodies:
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Human Monoclonal TYK2 Primary Antibody for ELISA, WB - ABIN967218
Shaw, Freeman, Scott, Fox, Bzik, Belkaid, Yap: Tyk2 negatively regulates adaptive Th1 immunity by mediating IL-10 signaling and promoting IFN-gamma-dependent IL-10 reactivation. in Journal of immunology (Baltimore, Md. : 1950) 2006
Show all 3 Pubmed References
Human Monoclonal TYK2 Primary Antibody for ELISA, WB - ABIN969448
Seto, Nakajima, Suto, Shimoda, Saito, Nakayama, Iwamoto: Enhanced Th2 cell-mediated allergic inflammation in Tyk2-deficient mice. in Journal of immunology (Baltimore, Md. : 1950) 2003
Show all 2 Pubmed References
Human Polyclonal TYK2 Primary Antibody for IHC - ABIN967219
Gauzzi, Velazquez, McKendry, Mogensen, Fellous, Pellegrini: Interferon-alpha-dependent activation of Tyk2 requires phosphorylation of positive regulatory tyrosines by another kinase. in The Journal of biological chemistry 1996
Show all 2 Pubmed References
Human Polyclonal TYK2 Primary Antibody for ICC, IF - ABIN4363628
Forsström, Axnäs, Stengele, Bühler, Albert, Richmond, Hu, Nilsson, Hudson, Rockberg, Uhlen: Proteome-wide epitope mapping of antibodies using ultra-dense peptide arrays. in Molecular & cellular proteomics : MCP 2014
New ELAVL1 (show ELAVL1 Antibodies)-TYK2 fusion gene is oncogenic in acute myeloid leukemia (show BCL11A Antibodies).
TYK2 gene variants do not seem to play an important role in Chagas disease susceptibility and/or chronic Chagas cardiomyopathy
TYK2 polymorphism is not associated with Dermatomyositis /Polymyositis in the Chinese Han population
TYK2 activating mutants and fusion proteins were detected in patients diagnosed with leukaemic diseases suggesting that TYK2 is a potent oncogene (show RAB1A Antibodies).
TYK2 genetic variants are differentially associated with common autoimmune diseases
High TYK2 expression is associated with B-cell lymphoma.
These data indicate that germline activating TYK2 mutations predispose to the development of ALL.
TYK2 rs280519 genotype was significantly related to severe necroinflammatory activity (NIA) grade of chronic hepatitis C patients.
TYK2 is associated with systemic sclerosis susceptibility and reinforce the relevance of the IL-12 (show IL12A Antibodies) pathway in SSc (show CYP11A1 Antibodies) pathophysiology.
Clinical genomic analysis of the current series of NF1 (show NF1 Antibodies)-MPNST cases found that TYK2 is a new gene mutated in MPNST.
Results show that loss of TYK2 does not affect disease severity of JAK2VF-induced murine myeloproliferative neoplasms (MPN (show PRSS27 Antibodies)) indicating that TYK2 has no cooperative effects with JAK2VF at the onset of MPN (show PRSS27 Antibodies).
mutated form which lacks tyrosine kinase (show TYRO3 Antibodies) activity restores differentiation of brown preadipocytes
Decreased Tyk2 expression in pancreatic beta cells due to mutation determines susceptibility to virus-induced diabetes mellitus.
Tyk2 protects against acute colitis in part by amplifying inflammation-induced epithelial IL-22 (show IL22 Antibodies) signaling to STAT3 (show STAT3 Antibodies)
A reduced survival fitness of the Th17 in the absence of Tyk-2 mediated by the up-regulation of SOCS3 (show SOCS3 Antibodies).
Data indicate the important role of Tyk2 in skin inflammation and the therapeutic potential of Tyk2 inhibition in psoriasis.
The conditional Tyk2 mouse strain will be instrumental to further dissect TYK2 functions in infection, inflammation and cancer.
In cellular assays, SAR (show SRL Antibodies)-20347 dose dependently (1 nM-10 muM) inhibited JAK1 (show JAK1 Antibodies)- and/or TYK2-dependent signaling from the IL-12 (show IL12A Antibodies)/IL-23 (show IL23A Antibodies), IL-22 (show IL22 Antibodies), and IFN-alpha (show IFNA Antibodies) receptors.
this report identifies Tyk2 as a prerequisite factor in the molecular networks that are involved in generation of IL-27 (show IL27 Antibodies).
This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E.
non-receptor tyrosine-protein kinase TYK2
, tyrosine kinase TYK2
, non-receptor tyrosine kinase Tyk2