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Granzyme B Activity Fluorometric Assay Kit Kit

AcA Reactivity: Mammalian Fluorometric
Pubmed (1)
Catalog No. ABIN1685869
$445.00
Plus shipping costs $45.00
100 tests
local_shipping Shipping to: United States
Delivery in 2 to 3 Business Days
  • Target
    GZMB
    Reactivity
    • 12
    • 5
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Mammalian
    Detection Method
    Fluorometric
    Application
    Activity Assay (AcA)
    Specificity
    Simple and Sensitive, rapid and convenient
    Kit contains all necessary reagents for measuring Granzyme B Activity.
    Characteristics
    Granzyme B Activity Assay Kit: Fluorometric Assay to Measure Granzyme B Activity & Characterize,Study Granzyme B Inhibitors. Rapid, Simple & Sensitive.
    Measurement of Granzyme B activity in various biological samples or purified Granzyme B activity, Screening Granzyme B inhibitors, characterize/Study Granzyme B inhibitors.
    Wave length for detection: Ex/Em = 380/500 nm.
    Components
    Granzyme B Assay Buffer
    Granzyme B Substrate
    Positive Control (Granzyme B Enzyme, human recombinant)
    AFC Standard (1mM)
  • Application Notes
    Measurement of Granzyme B activity in various biological samples or purified Granzyme B activity, Screening Granzyme B inhibitors, characterize/Study Granzyme B inhibitors.
    Restrictions
    For Research Use only
  • Storage
    -20 °C
    Expiry Date
    12 months
  • Bhela, Kempsell, Manohar, Dominguez-Villar, Griffin, Bhatt, Kivisakk-Webb, Fuhlbrigge, Kupper, Weiner, Baecher-Allan: "Nonapoptotic and extracellular activity of granzyme B mediates resistance to regulatory T cell (Treg) suppression by HLA-DR-CD25hiCD127lo Tregs in multiple sclerosis and in response to IL-6." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 194, Issue 5, pp. 2180-9, 2015 (PubMed).

  • Target
    GZMB
    Alternative Name
    Granzyme B (GZMB ELISA Kit Abstract)
    Synonyms
    CCPI, CGL-1, CGL1, CSP-B, CSPB, CTLA1, CTSGL1, HLP, SECT, granzyme B, GZMB
    Background
    Granzyme B (GZMB, EC number 3.4.21.79) also known as Granzyme-2 is a serine protease stored in the granules of activated cytotoxic T cells and NK cells. Upon target cell contact, Granzyme B is directionally exocytosed and with the assistance of perforin enters the target cell. With its unique substrate specificity (Granzyme B prefers an aspartic acid residue at the P1 site of its substrates), Granzyme B processes and activates various pro-caspases thereby inducing apoptosis in the target cell. In
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