SensoLyte® AMC Caspase Substrate Sampler Kit

Catalog No. ABIN1882428

Product Details

Target: Caspase (CASP)

Detection Method: Fluorometric

Application: Fluorescence Resonance Energy Transfer Microscopy (FRET)

Brand: SensoLyte®

Characteristics: The SensoLyte® Caspase Substrate Kit contains a series of AMC-based peptide substrates as fluorogenic indicators for assaying caspase protease activities. It provides the best solution for identifying a suitable substrate for designing AMC-based caspase assays. All the components in the kit are available in bulk package.

Application Details

Comment:

FRET-based Assay Kit

Restrictions: For Research Use only

Handling

Handling Advice: Keep Components A and B away from light

Storage: -20 °C

References

B?dziul, Jakubowicz-Gil, Paduch, G?owniak, Gawron: "Combined treatment with quercetin and imperatorin as a potent strategy for killing HeLa and Hep-2 cells." in: Molecular and cellular biochemistry, Vol. 392, Issue 1-2, pp. 213-27, (2014) (PubMed).

B?dziul, Jakubowicz-Gil, Langner, Rzeski, G?owniak, Gawron: "The effect of quercetin and imperatorin on programmed cell death induction in T98G cells in vitro." in: Pharmacological reports : PR, Vol. 66, Issue 2, pp. 292-300, (2014) (PubMed).

Jakubowicz-Gil, Langner, B?dziul, Wertel, Rzeski: "Apoptosis induction in human glioblastoma multiforme T98G cells upon temozolomide and quercetin treatment." in: Tumour biology, Vol. 34, Issue 4, pp. 2367-78, (2013) (PubMed).

Target Details

Target: Caspase (CASP)

Alternative Name: Caspase (CASP Products)

Background: Caspases play important roles in apoptosis and cell signaling. They are also identified as drug-screening targets. AMC-based substrates yield blue fluorescence upon protease cleavage (Ex/Em=354 nm/442 nm). They are widely used to monitor caspase activity.