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Endoglin ELISA Kit

ENG Reactivity: Human Colorimetric Sandwich ELISA 6-10000 pg/mL
Catalog No. ABIN2042388
  • Target See all Endoglin (ENG) ELISA Kits
    Endoglin (ENG)
    Reactivity
    • 6
    • 6
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
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    Human
    Detection Method
    Colorimetric
    Method Type
    Sandwich ELISA
    Detection Range
    6-10000 pg/mL
    Minimum Detection Limit
    6 pg/mL
    Application
    ELISA
    Brand
    BioAssay™
    Cross-Reactivity (Details)
    There is no detectable cross-reactivity with other relevant proteins.
    Sensitivity
    < 15 pg/mL
    Components
    96-well plate pre-coated with anti-CD105, Human
    Lyophilized recombinant CD105, Human standard, 10 ng/tube, 2Ea
    Avidin-Biotin-Peroxidase Complex (ABC), 130 µL (1:100 dilution)
    Sample diluent buffer, 30 mL
    Antibody diluent buffer, 10 mL
    ABC diluent buffer, 10 mL
    TMB color developing agent, 10 mL
    TMB stop solution, 10 mL
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  • Plate
    Pre-coated
    Protocol
    Sandwich ELISA quantitative detection kit for Human CD105 in cell culture supernates, serum and plasma (heparin, EDTA).CD105, also called Endoglin, is a homodimeric membrane glycoprotein primarily associated with human vascular endothelium. It is also found on bone marrow proerythroblasts, activated monocytes, and lymphoblasts in childhood leukemia. Endoglin is a component of the transforming growth factor-beta (TGFB) receptor complex and binds TGFB1 with high affinity.1 CD105 gene is mapped to 9q34.1. The coding region of the gene contains 14 exons.2 The protein consists of a homodimer of 180kDA with disulfide links. Endoglin has a role in the development of the cardiovascular system and in vascular remodeling. Its expression is regulated during heart development. Furthermore, it also has a role in the balance of ALK1 and ALK5 signaling to regulate endothelial cell proliferation.3 Moreover, the elevated expression of endoglin in the surgically excised CNVMs suggested a persisting postmitotic activation in an advanced stage of neovascular tissue.4 The standard product used in this kit is extracellular part of recombinant human CD105, from E26 to G586. As a result of glycosylation, the molecular mass is 75-85kD.
    Restrictions
    For Research Use only
  • Storage
    4 °C/-20 °C
  • Target See all Endoglin (ENG) ELISA Kits
    Endoglin (ENG)
    Alternative Name
    CD105 (ENG Products)
    Synonyms
    ENG ELISA Kit, MGC137842 ELISA Kit, DKFZp469D0419 ELISA Kit, END ELISA Kit, HHT1 ELISA Kit, ORW1 ELISA Kit, AI528660 ELISA Kit, AI662476 ELISA Kit, CD105 ELISA Kit, S-endoglin ELISA Kit, endoglin ELISA Kit, ENG ELISA Kit, Eng ELISA Kit
    Gene ID
    2022
    UniProt
    P17813
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