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Results show that XMAP215 can be used as a handle to sense and mechanically manipulate the dynamics of the microtubule tip.
XMAP215 activity sets spindle length by controlling the total mass of spindle microtubules.
Eribulin binding to the tip of microtubules and subsequent loss of ch-TOG is a priming event leading to alterations in microtubule dynamics and breast cancer cell migration.
Data show that cytoskeleton associated protein 5 (chTOG) only weakly promotes importin-regulated microtubule nucleation, but acts synergistically with microtubule- associated protein TPX2 (show TPX2 ELISA Kits).
Aurora-A kinase (show AURKA ELISA Kits) does not regulate TACC3 (show TACC3 ELISA Kits)-chTOG complex formation, indicating that Aurora-A (show AURKA ELISA Kits) solely functions as a recruitment factor for the TACC3 (show TACC3 ELISA Kits)-chTOG complex to centrosomes and proximal mitotic spindles.
Data show that five genes CKAP5, KPNB1 (show KPNB1 ELISA Kits), RAN, TPX2 (show TPX2 ELISA Kits) and KIF11 (show KIF11 ELISA Kits) were shown to be essential for tumor cell survival in both head and neck squamous cell carcinoma (HNSCC)and non-small cell lung cancer (NSCLC), but most particularly in HNSCC.
These observations indicate that EB1 (show MAPRE2 ELISA Kits) and ch-TOG regulate microtubule organisation differently via distinct regions in the plus ends of microtubules.
Clathrin promotes centrosome maturation by stabilizing the microtubule-binding protein ch-TOG, defining a novel role for the clathrin-ch-TOG complex.
Data show that ILK (show ILK ELISA Kits) performs its centrosome clustering activity in a centrosome-dependent, manner through the microtubule regulating proteins TACC3 (show TACC3 ELISA Kits) and ch-TOG.
the association between aurora A (show AURKA ELISA Kits) phosphorylation and spindle apparatus; regulation from aurora A (show AURKA ELISA Kits) is mediated by CHC (show CLTC ELISA Kits) in recruiting phospho-TACC3 (show TACC3 ELISA Kits) and subsequently ch-TOG to mitotic spindles.
Data show that 4-oxo-4-HPR (show HPR ELISA Kits) inhibited tubulin (show TUBB ELISA Kits) polymerization and modulated gene expression of spindle aberration associated genes Kif 1C, Kif 2A, Eg5 (show KIF11 ELISA Kits), Tara (show TRIOBP ELISA Kits), tankyrase-1 (show TNKS ELISA Kits), centractin (show ACTR1A ELISA Kits), and TOGp.
Interaction of the transforming acidic coiled-coil 1 (TACC1) protein with ch-TOG and GAS41/NuBI1 suggests multiple TACC1-containing protein complexes in human cells
our results demonstrate that CKAP5 is important in oocyte maturation and early embryo development, and CKAP5 might work together with CLTC (show CLTC ELISA Kits) in mouse oocyte maturation
in hippocampal neurons TOG is required for granule assembly, granule translation and synaptic plasticity, and affects behavior
ch-TOG promotes axonal development and is expressed in brain throughout development.
This gene encodes a cytoskeleton-associated protein which belongs to the TOG/XMAP215 family. The N-terminal half of this protein contains a microtubule-binding domain and the C-terminal half contains a KXGS motif for binding tubulin dimers. This protein has two distinct roles in spindle formation\; it protects kinetochore microtubules from depolymerization and plays an essential role in centrosomal microtubule assembly. This protein may be necessary for the proper interaction of microtubules with the cell cortex for directional cell movement. It also plays a role in translation of the myelin basic protein (MBP) mRNA by interacting with heterogeneous nuclear ribonucleoprotein (hnRNP) A2, which associates with MBP. Alternatively spliced transcript variants encoding different isoforms have been identified.
cytoskeleton associated protein 5
, microtubule associated protein XMAP215
, cytoskeleton-associated protein 5
, microtubule-associated protein 215
, colonic and hepatic tumor over-expressed protein
, Cytoskeleton-associated protein 5
, cytoskeleton-associated protein 5-like
, colonic and hepatic tumor over-expressed gene protein
, colonic and hepatic tumor overexpressed gene protein