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anti-Human Cullin 2 Antibodies:
anti-Mouse (Murine) Cullin 2 Antibodies:
anti-Rat (Rattus) Cullin 2 Antibodies:
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Human Polyclonal Cullin 2 Primary Antibody for IP, WB - ABIN233771
Shiraishi, Zhou, Aoki, Sato, Chiba, Tanaka, Yoshida, Nabeshima, Nabeshima, Tamura: TBP-interacting protein 120B (TIP120B)/cullin-associated and neddylation-dissociated 2 (CAND2) inhibits SCF-dependent ubiquitination of myogenin and accelerates myogenic differentiation. in The Journal of biological chemistry 2007
Show all 5 Pubmed References
Human Polyclonal Cullin 2 Primary Antibody for ELISA, WB - ABIN563635
Maine, Mao, Komarck, Burstein: COMMD1 promotes the ubiquitination of NF-kappaB subunits through a cullin-containing ubiquitin ligase. in The EMBO journal 2007
Mouse (Murine) Polyclonal Cullin 2 Primary Antibody for ELISA, WB - ABIN4300963
Argyropoulos, Stütz, Ilnytska, Rice, Teran-Garcia, Rao, Bouchard, Rankinen: KIF5B gene sequence variation and response of cardiac stroke volume to regular exercise. in Physiological genomics 2009
Human Polyclonal Cullin 2 Primary Antibody for ELISA, ICC - ABIN6261115
Meng, Chen, Han, Qian, Wang, Zhong, Qin, Zhang, Gao, Lei, Yang, Yang, Zhang, Liu, Liu, Zhou, Sun, Yang: Twist1 Regulates Vimentin through Cul2 Circular RNA to Promote EMT in Hepatocellular Carcinoma. in Cancer research 2018
Twist1 bound the Cul2 promoter.
direct evidence that both A3A and HPV16 E7 interact with CUL2, suggesting that the E7-CUL2 complex formed during HPV infection may regulate A3A protein levels in the cell.
The crystal structure of a pentameric CRL2(VHL) complex, composed of Cul2, Rbx1, Elongin B, Elongin C, and pVHL reveals hydrophobic contact residues critical for the Cul2 interactions.
Results suggest that E7 recruited CUL2, driven by CUL2/E2F1/miR-424 regulatory loop, is overexpressed and accelerates HPV16-induced cervical carcinogenesis.
misfolded TDP-43 is cleared by VHL/CUL2 in a step-wise manner via fragmentation.
Cullins are a family of NEDD8 targets important in the stabilization and degradation of proteins, such as hypoxia-inducible factor (HIF1A), via Cullin-2.
Nevertheless, the identification of the Cul2 box may allow prediction of Cullin specificity for all E4orf6-containing Adenoviridae.
a novel link between the oncoprotein PRAME and the conserved EKC complex
Study finds that UBXN7 over-expression converts CUL2 to its neddylated form and causes the accumulation of non-ubiquitylated HIF1alpha.
The authors applied protein-complex purification strategies and identified PRAME as a substrate recognition subunit of a Cullin2-based E3 ubiquitin ligase.
The data suggest that neither HIF1alpha nor CUL2 mutation may play a central role in HIF1alpha activation in gastric, colorectal, breast, lung and hepatocellular carcinomas, and acute leukemias.
Cullin selection is determined by specific Elongin C and Skp1 sequences
the HPV16 E7-associated cullin 2 ubiquitin ligase complex contributes to aberrant degradation of the pRB tumor suppressor in HPV16 E7-expressing cells.
CUL2 is required for normal vasculogenesis, at least in part mediated by its regulation of HIF-mediated transcription.
Authors show that bovine immunodeficiency virus Vif interacts with Cullin 2 (CUL2), ELOB/C, and RBX1, but not with CBF-beta or CUL5, to form a CRL2 E3 ubiquitin ligase and degrade the restrictive bovine APOBEC3 proteins (A3Z2Z3 and A3Z3).
CUL-2(LRR-1) and UBXN-3 drive replisome disassembly during DNA replication termination and mitosis.
CUL-2 RING E3 ubiquitin-ligase acts at multiple levels to control germline development; CUL-2 may similarly regulate germline development in other organisms as well.
Results indicate that LRR-1 acts as a nuclear substrate-recognition subunit of a Cullin 2-RING E3 ligase complex (CRL2(LRR-1)), which ensures DNA replication integrity.
The C. elegans p97/CDC-48-UFD-1-NPL-4 complex controls the sperm-oocyte switch by regulating CUL-2-mediated TRA-1A proteasome degradation.
segregation of the germ plasm involves both stabilization of germline proteins in the germ line and cullin-dependent degradation in the soma
Results establish that zyg-11 and the cullin cul-2 promote the metaphase-to-anaphase transition and M phase exit at meiosis II in Caenorhabditis elegans.
Data show that inactivation of ZYG-11 produces meiotic and polarity reversal defects similar to those observed in CUL-2 mutants, suggesting that the two proteins function in the same pathways.
oocyte maturation from pachytene exit and MPK-1 activation are redundantly controlled by the RBX-2-CUL-5- and RBX-1-CUL-2-based complexes.
TRA-1 is regulated by degradation mediated by a CUL-2-based ubiquitin ligase complex
Fem-1 protein is a substrate-specific adaptor for a CUL-2-based ubiquitin ligase.
MEL-26 levels are kept low by the action of another type of ubiquitin ligase, which contains CUL-2
Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin- conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (By similarity). The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF).
, cullin-2 (cul-2)
, cullin 2