anti-Human Dynein, Light Chain, LC8-Type 1 antibody for Immunoprecipitation

Recommended Dynein, Light Chain, LC8-Type 1 Antibody (supplied by: Log in to see )

Antigen
Dynein, Light Chain, LC8-Type 1 (DYNLL1) Antibodies
  • DLC1
  • DLC8
  • DNCL1
  • DNCLC1
  • LC8
  • LC8a
  • PIN
  • hdlc1
  • dynll2
  • wu:fd56c09
  • zgc:73406
  • Dlc8
  • Dnclc1
  • Pin
  • 8kDLC
  • lc8
  • dlc1
  • dlc8
  • lc8a
  • dncl1
  • dnclc1
  • dynll1a
  • MGC68763
  • CDLC2
  • dynll1
  • dynll1b
  • pin
  • MGC89636
  • dynein light chain LC8-type 1
  • dynein, light chain, LC8-type 1
  • dynein light chain LC8-type 1 S homeolog
  • dynein light chain LC8-type 1 L homeolog
  • DYNLL1
  • dynll1
  • Dynll1
  • dynll1.S
  • dynll1.L
Epitope
AA 1-89
6
5
3
2
1
1
1
1
1
1
1
Reactivity
Human, Rat (Rattus)
59
20
18
7
7
7
7
7
6
4
4
4
4
4
3
3
3
1
Host
Mouse
34
23
3
Clonality
Monoclonal
Conjugate
Un-conjugated
4
4
3
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Formalin-fixed Sections) (IHC (f)), Immunofluorescence (IF), Immunoprecipitation (IP), Western Blotting (WB)
54
16
14
7
5
5
5
2
1
Options
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Catalog No. ABIN968140
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Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN200808 FACS IP WB Rat IgG2a Log in to see

General

Antigen Dynein, Light Chain, LC8-Type 1 (DYNLL1) Antibodies
Epitope AA 1-89
(6), (5), (3), (2), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human, Rat (Rattus)
(59), (20), (18), (7), (7), (7), (7), (7), (6), (4), (4), (4), (4), (4), (3), (3), (3), (1)
Host Mouse
(34), (23), (3)
Clonality (Clone)
Monoclonal   ( )
Conjugate Un-conjugated
(4), (4), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Immunohistochemistry (Formalin-fixed Sections) (IHC (f)), Immunofluorescence (IF), Immunoprecipitation (IP), Western Blotting (WB)
(54), (16), (14), (7), (5), (5), (5), (2), (1)
Pubmed 2 references available
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Product details

Target Details Application Details Handling References Images
Cross-Reactivity Human
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Immunogen Rat PIN aa. 1-89
Clone 4-PIN
Isotype IgG1

Target Details

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Antigen
Alternative Name PIN (DYNLL1 Antibody Abstract)
Background PIN (protein inhibitor of nNOS) is a small protein of 89 amino acids initially described as a light chain subunit of dynein and as an inhibitor of the neuronal nitric oxide synthase isoform (nNOS). In vitro, PIN has been reported to bind to a unique nNOS domain encompassing amino acids 163-245. PIN inhibits nNOS activity and blocks the formation of the active nNOS dimer. Although ubiquitously expressed, PIN levels are reportedly highest in brain and testis. Immunolocalization studies in Drosophila melanogaster detected a cytoplasmic distribution of PIN. Partial-loss-of-function of PIN resulted in morphologic and developmental changes in the bristles, wings, and female sterility of D. melanogaster. Deletion of PIN resulted in lethality with the characteristic morphology of apoptotic cells. This antibody is routinely tested by western blot analysis.
Synonyms: Protein Inhibitor of nNOS
Molecular Weight 10 kDa
Pathways M Phase, Tube Formation, Positive Regulation of Endopeptidase Activity

Application Details

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Comment

Related Products: ABIN968545, ABIN967389

Restrictions For Research Use only

Handling

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Format Liquid
Concentration 250 μg/mL
Buffer Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store undiluted at -20° C.

References

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Product cited in:

Dick, Ray, Salz, Chia: "Cytoplasmic dynein (ddlc1) mutations cause morphogenetic defects and apoptotic cell death in Drosophila melanogaster." in: Molecular and cellular biology, Vol. 16, Issue 5, pp. 1966-77, 1996

Jaffrey, Snyder: "PIN: an associated protein inhibitor of neuronal nitric oxide synthase." in: Science (New York, N.Y.), Vol. 274, Issue 5288, pp. 774-7, 1996

Images

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Supplier Images
Western Blotting (WB) image for anti-Dynein, Light Chain, LC8-Type 1 (DYNLL1) (AA 1-89) antibody (ABIN968140) Western blot analysis of PIN on a rat cerebrum lysate. Lane 1: 1:250, lane 2: 1:500, ...
Immunofluorescence (IF) image for anti-Dynein, Light Chain, LC8-Type 1 (DYNLL1) (AA 1-89) antibody (ABIN968140) Immunofluorescence staining of rat neurons.