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study shows that decreased gene and protein expression of SKA2 observed in the prefrontal cortex of suicide victims is specific to suicide, which was not observed in the brain of nonsuicidal patients. It also indicates reduced SKA2 expression in suicide is independent of psychiatric diagnosis, since it is observed in all diagnostic groups studied.
Possible association between SKA2 expression in prefrontal cortex and MDD.
Data show that HOTAIR might act as an endogenous 'sponge' of miR (show MLXIP Proteins)-141, thereby regulating the derepression of SKA2.
The study adds evidence that CREB (show CREB1 Proteins), a tumor oncogene (show RAB1A Proteins), promotes renal cell carcinoma (show MOK Proteins) proliferation. It probably achieves this by increasing SKA2 expression
Kinetochores mature through Ska1 (show SKA1 Proteins)/ska2/Ska3 (show SKA3 Proteins) complex recruitment and this is required for improved load-bearing capacity and silencing of the spindle assembly checkpoint.
p53 (show TP53 Proteins) negatively regulates the expression of the PRR11-SKA2 bidirectional transcription unit through NF-Y, suggesting that the inability to repress the PRR11-SKA2 bidirectional transcription unit after loss of p53 (show TP53 Proteins) might contribute to tumorigenesis.
these data establish the importance of SKA2 for cortisol stress responsivity and the development of post-traumatic stress disorder and provide further evidence that SKA2 is a promising biomarker for stress-related disorders including PTSD.
Results suggest that DNA methylation (show HELLS Proteins)(adj) of SKA2 in blood indexes stress-related psychiatric phenotypes and neurobiology, pointing to its potential value as a biomarker of stress exposure and susceptibility.
DNA methylation (show HELLS Proteins) of the SKA2 gene has been implicated as a biomarker of suicide risk and posttraumatic stress disorder.
SKA2 is hypothesized to reduce the ability to suppress cortisol following stress.
Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it is required for ska1 localization (By similarity).
family with sequence similarity 33, member A
, spindle and KT (kinetochore) associated 2
, spindle and kinetochore-associated protein 2
, Protein FAM33A