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MAD1 (show MXD1 Proteins) and Proto-Oncogene (show RAB1A Proteins) Proteins c-myc (show MYC Proteins) reciprocally regulate ribosomal DNA transcription, providing a mechanism for coordination of ribosome biogenesis and cell growth
MAD1 (show MXD1 Proteins) is present in mouse oocytes at all stages during the first meiosis and that it participates in spindle checkpoint during meiosis
Data show that the loss of Trrap leads to chromosome missegregation, mitotic exit failure and compromised mitotic checkpoints, which are caused by defective Trrap-mediated transcription of the mitotic checkpoint (show BUB3 Proteins) proteins Mad1 (show MXD1 Proteins) and Mad2 (show MXI1 Proteins).
identified mouse Telomeric Repeat Binding Factor 1 (Trf1 (show TERF1 Proteins)) as a protein that interacts directly with the spindle checkpoint protein Mad1 (show MXD1 Proteins) and the mitotic kinase Nek2 (show NEK2 Proteins)
Together these data demonstrate that the MYC (show MYC Proteins)-antagonist MAD1 (show MXD1 Proteins) and cyclin-dependent kinase inhibitor p27(Kip1 (show CDKN1B Proteins)) cooperate to regulate the self-renewal and differentiation of HSCs in a context-dependent manner.
the simultaneous knockdown of p18 (show CDKN2C Proteins), p27 (show CDKN1B Proteins) and MAD1 (show MXD1 Proteins) with a medium of only stem cell factor (show KITLG Proteins) can induce long-term culture-initiating cell expansion despite the loss of engraftment ability
Therefore, Mps1 (show IDUA Proteins) promotes checkpoint activation through sequentially phosphorylating Knl1 (show CASC5 Proteins), Bub1 (show BUB1 Proteins), and Mad1 (show MXD1 Proteins). This sequential multi-target phosphorylation cascade makes the checkpoint highly responsive to Mps1 (show IDUA Proteins) and to kinetochore-microtubule attachment.
This study showed that MAD1L1 as a susceptibility gene for both of these genetically overlapping disorders is associated with a decreased bottom-up responsiveness of the mesolimbic reward system and related cortical regions involved in the salience network as well as with reduced top-down control processes.
Results show that low DNA methylation (show HELLS Proteins) levels of LINC00682, MAD1L1, and LINE-2 was strongly correlated with hepatocellular carcinomas recurrence, patient disease-free survival, and/or overall survival.
MAD1L1 positive expression may be associated with tumour progression and metastasis in small-cell lung cancer (SCLC) and may thus serve as a new biomarker for prognosis in these patients.
In this review, we highlight a novel Mad1 role in chromosome alignment, which is the first conserved mechanism that links the spindle assembly checkpoint and kinesin-mediated chromosome gliding.
MAD1L1 Arg558His and MAD2L1 (show MAD2L1 Proteins) Leu84Met interaction with smoking increase the risk of colorectal cancer
MAD1L1 rs12666575 polymorphism may play a protective role against schizophrenia (SCZ) in the Chinese population. rs12666575 may be associated with general psychopathology and thought disturbance in SCZ patients.
We also show that replication perturbations result in relocalization of MAD1 (show MXD1 Proteins)/MAD2 (show MAD2L1 Proteins) in human cells, suggesting that the role of SAC (show ADCY10 Proteins) in DNA repair is conserved.
Mad1 (show MXD1 Proteins) has a role in secretion and cell migration.
MAD1 (show MXD1 Proteins) kinetochore localization dictates the spindle assembly checkpoint in metaphase.
MAD1L1 is a component of the mitotic spindle-assembly checkpoint that prevents the onset of anaphase until all chromosome are properly aligned at the metaphase plate. MAD1L1 functions as a homodimer and interacts with MAD2L1. MAD1L1 may play a role in cell cycle control and tumor suppression. Three transcript variants encoding the same protein have been found for this gene.
MAD1-like protein 1
, mitotic arrest deficient 1-like 1
, mitotic arrest deficient 1-like protein 1
, mitotic spindle assembly checkpoint protein MAD1
, mitotic checkpoint MAD1 protein homolog
, mitotic-arrest deficient 1, yeast, homolog-like 1
, tax-binding protein 181
, tumor protein p53 inducible protein 9