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Human Polyclonal FAF1 Primary Antibody for IHC, ELISA - ABIN1002283
Ryu, Kim: Apoptosis induced by human Fas-associated factor 1, hFAF1, requires its ubiquitin homologous domain, but not the Fas-binding domain. in Biochemical and biophysical research communications 2001
Show all 4 Pubmed References
Human Polyclonal FAF1 Primary Antibody for WB - ABIN966117
Park, Jang, Lee, Lee, Kim: Fas-associated factor-1 inhibits nuclear factor-kappaB (NF-kappaB) activity by interfering with nuclear translocation of the RelA (p65) subunit of NF-kappaB. in The Journal of biological chemistry 2004
Show all 2 Pubmed References
Human Polyclonal FAF1 Primary Antibody for ELISA, WB - ABIN564825
Baron, Pedrioli, Tyagi, Johnson, Wood, Fountaine, Wightman, Alexandru: VAPB/ALS8 interacts with FFAT-like proteins including the p97 cofactor FAF1 and the ASNA1 ATPase. in BMC biology 2014
Human Polyclonal FAF1 Primary Antibody for IP, IHC - ABIN223070
Altomare, Menges, Pei, Zhang, Skele-Stump, Carbone, Kane, Testa: Activated TNF-alpha/NF-kappaB signaling via down-regulation of Fas-associated factor 1 in asbestos-induced mesotheliomas from Arf knockout mice. in Proceedings of the National Academy of Sciences of the United States of America 2009
This study reveals clear genetic-statistical evidence for a link of KRT8 (show KRT8 Antibodies), FAF1 and PTH1R (show PTH1R Antibodies) with some of leg weakness related traits in pigs.
Knockdown of FAF1 suppressed Sanguinarine (SNG)-induced inhibition of cell proliferation, invasion, and migration and induction of cell cycle arrest and apoptosis in NSCLC cells. SNG also inhibited implanted tumor growth and increased FAF1 expression in tumors in vivo.
These data demonstrate the presence of an FAF1-PARP1 (show PARP1 Antibodies) axis that is involved in oxidative stress-induced (show SQSTM1 Antibodies) necrosis and in the pathology of Parkinson's disease.
FAF1 physically interacts with XIAP (show XIAP Antibodies). FAF1 attenuates XIAP (show XIAP Antibodies)-mediated NF-kappaB (show NFKB1 Antibodies) activation.
confirmation of the association between rs17106184 (FAF1) and Type 2 Diabetes in a northern Han Chinese population
FAF1 plays a novel role in negatively regulating virus-induced IFN-beta (show IFNB1 Antibodies) production and the antiviral response by inhibiting the translocation of active, phosphorylated IRF3 (show IRF3 Antibodies) from the cytosol to the nucleus
Progression of the DNA replication fork is coordinated by FAF1. FAF1 binds to the licensing factor CDT-1 (show CDT1 Antibodies) and additional ubiquitylated proteins, thus promoting CDC48 (show vcp Antibodies)-dependent turnover and disassembly of DNA replication factor (show CDT1 Antibodies) complexes.
Report a novel role for FAF1 in regulating CD40-induced NFkappaB activation via a negative feedback loop.
The repertoire of VAPB (show VAPB Antibodies) interactors is more diverse than previously anticipated and link VAPB (show VAPB Antibodies) to the function of ATPase (show DNAH8 Antibodies) complexes such as p97 (show EIF4G2 Antibodies)/FAF1 and ASNA1 (show ASNA1 Antibodies)/transmembrane-domain recognition complex.
long-chain unsaturated fatty acids also induced polymerization of Fas-associated factor 1 (FAF1), the only other mammalian protein that contains a UAS domain homologous to that of Ubxd8 (show FAF2 Antibodies)
Data indicate that Npl4-Ufd1 (show UFD1L Antibodies) heterodimer is required for VCP (show vcp Antibodies)-FAF1 interaction.
FAF1 knockdown immune cells were highly susceptible to RNA virus infection and showed low levels of inflammatory cytokines and type I interferon (show IFNA Antibodies) (IFN) production.
Increased FAF1 expression triggers caspase-3 (show CASP3 Antibodies) cleavage and activation, leading to hyperphosphorylated tau aggregation and subsequent neurofibrillary tangles formation, in turn initiating apoptosis.
Taken together, these results suggest a new role for FAF1: that of a positive modulator for Parkinson's disease .
FAF1 is a novel inhibitory factor of canonical Wnt (show WNT2 Antibodies) signaling pathway
Capsaicin-induced cancer cell apoptosis involves FAF1, a TRPV1 (show TRPV1 Antibodies) associated protein.
Analysis of FAF1 expression revealed that the protein is present in early preimplantation stages, while embryonic expression of Faf1 mRNA becomes appreciable at 4-cell stage.
Data show that Faf1 protein level is down-regulated during apoptosis in a caspase-3 (show CASP3 Antibodies)- and Apaf1 (show APAF1 Antibodies)-dependent manner.
analysis of the negative feedback regulation of Aurora-A (show AURKA Antibodies) via phosphorylation of Fas-associated factor-1
Interaction of Fas ligand (TNFSF6) with the FAS antigen (TNFRSF6) mediates programmed cell death, also called apoptosis, in a number of organ systems. The protein encoded by this gene binds to FAS antigen and can initiate apoptosis or enhance apoptosis initiated through FAS antigen. Initiation of apoptosis by the protein encoded by this gene requires a ubiquitin-like domain but not the FAS-binding domain.
Fas (TNFRSF6) associated factor 1
, FAS-associated factor 1
, FAS-associated factor 1-like
, TNFRSF6-associated factor 1
, UBX domain protein 3A
, UBX domain-containing protein 12
, UBX domain-containing protein 3A