anti-Chicken BCL2 antibody for Immunohistochemistry

Recommended BCL2 Antibody (supplied by: Log in to see )

Antigen
B-Cell CLL/lymphoma 2 (BCL2) Antibodies
  • Bcl-2
  • PPP1R50
  • bcl-2
  • AW986256
  • C430015F12Rik
  • D630044D05Rik
  • D830018M01Rik
  • BCL-2
  • Bcl2
  • BCL2, apoptosis regulator
  • B cell leukemia/lymphoma 2
  • B-cell CLL/lymphoma 2a
  • B-cell CLL/lymphoma 2 protein
  • BCL2
  • Bcl2
  • bcl2a
  • BCL-2
Epitope
AA 49-179
165
77
66
64
44
31
25
25
24
21
18
15
15
15
13
13
13
11
9
9
7
6
6
5
5
5
5
4
4
4
3
3
3
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Chicken, Dog (Canine), Human, Mouse (Murine), Rat (Rattus)
1066
265
219
54
27
22
18
18
5
4
4
3
2
2
2
1
Host
Mouse
579
553
18
6
2
2
2
Clonality
Monoclonal
Conjugate
This BCL2 antibody is un-conjugated
53
50
45
41
35
25
24
16
15
15
14
14
14
14
14
14
13
13
7
7
7
6
6
6
6
6
6
6
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
853
398
396
342
339
326
230
196
171
81
42
15
14
13
12
11
9
4
3
2
1
1
1
1
1
1
1
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Pubmed
5 references available

Available images

Western Blotting (WB) image for anti-B-Cell CLL/lymphoma 2 (BCL2) (AA 49-179) antibody (ABIN968024)
image for anti-B-Cell CLL/lymphoma 2 (BCL2) (AA 49-179) antibody (ABIN968024)
Catalog No. ABIN968024
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Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN968025 IF IP IHC WB Mouse IgG1 AA 49-179 Log in to see 7-Bcl 5

General

Antigen B-Cell CLL/lymphoma 2 (BCL2) Antibodies
Epitope AA 49-179
(165), (77), (66), (64), (44), (31), (25), (25), (24), (21), (18), (15), (15), (15), (13), (13), (13), (11), (9), (9), (7), (6), (6), (5), (5), (5), (5), (4), (4), (4), (3), (3), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Chicken, Dog (Canine), Human, Mouse (Murine), Rat (Rattus)
(1066), (265), (219), (54), (27), (22), (18), (18), (5), (4), (4), (3), (2), (2), (2), (1)
Host Mouse
(579), (553), (18), (6), (2), (2), (2)
Clonality (Clone)
Monoclonal   ( )
Conjugate This BCL2 antibody is un-conjugated
(53), (50), (45), (41), (35), (25), (24), (16), (15), (15), (14), (14), (14), (14), (14), (14), (13), (13), (7), (7), (7), (6), (6), (6), (6), (6), (6), (6), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
(853), (398), (396), (342), (339), (326), (230), (196), (171), (81), (42), (15), (14), (13), (12), (11), (9), (4), (3), (2), (1), (1), (1), (1), (1), (1), (1)
Pubmed 5 references available
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Product Details anti-BCL2 Antibody

Target Details BCL2 Application Details Handling References for anti-BCL2 antibody (ABIN968024) Images
Cross-Reactivity Chicken, Dog (Canine), Mouse (Murine), Rat (Rattus)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Immunogen Human Bcl-2 aa. 49-179
Clone 7-Bcl
Isotype IgG1

Target Details BCL2

Product Details anti-BCL2 Antibody Application Details Handling References for anti-BCL2 antibody (ABIN968024) Images back to top
Antigen
Alternative Name Bcl-2 (BCL2 Antibody Abstract)
Background Human hematopoietic malignancies are often characterized by gene rearrangements which deregulate gene expression. The Bcl-2 gene (B-cell leukemia/lymphoma 2) was discovered by walking the chromosomal breakpoints t(14,18). This gene consists of two exons and several transcripts that encode two different protein products, Bcl-2alpha and Bcl-2beta. Both are approximately 26-30kDa and differ at their C-terminal region. Bcl-2 suppresses programmed cell death (apoptosis) and this property appears to be modulated by homodimerization or association with Bax and Bad, two cell death promoters. This antibody is routinely tested by western blot analysis.
Molecular Weight 26 kDa
Pathways MAPK Signaling, PI3K-Akt Signaling, Apoptosis, Caspase Cascade in Apoptosis, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Skeletal Muscle Fiber Development, Autophagy, Smooth Muscle Cell Migration, Negative Regulation of intrinsic apoptotic Signaling

Application Details

Product Details anti-BCL2 Antibody Target Details BCL2 Handling References for anti-BCL2 antibody (ABIN968024) Images back to top
Comment

Related Products: ABIN968537, ABIN967389
Restrictions For Research Use only

Handling

Product Details anti-BCL2 Antibody Target Details BCL2 Application Details References for anti-BCL2 antibody (ABIN968024) Images back to top
Format Liquid
Concentration 250 μg/mL
Buffer Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store undiluted at -20° C.

References for anti-BCL2 antibody (ABIN968024)

Product Details anti-BCL2 Antibody Target Details BCL2 Application Details Handling Images back to top
Product cited in:

Decary, Decesse, Ogryzko, Reed, Naguibneva, Harel-Bellan, Cremisi: "The retinoblastoma protein binds the promoter of the survival gene bcl-2 and regulates its transcription in epithelial cells through transcription factor AP-2." in: Molecular and cellular biology, Vol. 22, Issue 22, pp. 7877-88, 2002

Naga Prasad, Laporte, Chamberlain, Caron, Barak, Rockman: "Phosphoinositide 3-kinase regulates beta2-adrenergic receptor endocytosis by AP-2 recruitment to the receptor/beta-arrestin complex." in: The Journal of cell biology, Vol. 158, Issue 3, pp. 563-75, 2002

Ayllón, Cayla, García, Roncal, Fernández, Albar, Martínez, Rebollo: "Bcl-2 targets protein phosphatase 1 alpha to Bad." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 166, Issue 12, pp. 7345-52, 2001

Kihara, Shimohama, Sawada, Honda, Nakamizo, Shibasaki, Kume, Akaike: "alpha 7 nicotinic receptor transduces signals to phosphatidylinositol 3-kinase to block A beta-amyloid-induced neurotoxicity." in: The Journal of biological chemistry, Vol. 276, Issue 17, pp. 13541-6, 2001

Background publications

Tsujimoto, Croce: "Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 83, Issue 14, pp. 5214-8, 1986

Images

Product Details anti-BCL2 Antibody Target Details BCL2 Application Details Handling References for anti-BCL2 antibody (ABIN968024) back to top
Supplier Images
Western Blotting (WB) image for anti-B-Cell CLL/lymphoma 2 (BCL2) (AA 49-179) antibody (ABIN968024) Western blot analysis of Bcl-2 (clone 7) on Jurkat lysate. Lane 1: 1:500, lane 2: 1:1...
image for anti-B-Cell CLL/lymphoma 2 (BCL2) (AA 49-179) antibody (ABIN968024) Immunohistochemical staining of Bcl2 (clone 7) on Rabbit Lung