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|Antigen||ELK1, Member of ETS Oncogene Family (ELK1) Antibodies|
|Reactivity||Dog (Canine), Human, Monkey, Mouse (Murine), Rat (Rattus), Zebrafish (Danio rerio) Alternatives|
|Conjugate||This ELK1 antibody is un-conjugated Alternatives|
Western Blotting (WB)
|1 reference available|
|Supplier||Log in to see|
Product Details anti-ELK1 AntibodyTarget Details ELK1 Application Details Handling References for anti-ELK1 antibody (ABIN319099) Images
|Specificity||This antiobdy is specific for Ets-like protein-1 (ELK-1) when phosphorylated at serine 383.|
|Immunogen||Synthetic phosphopeptide corresponding to an amino acid sequence within ELK-1 which includes phosphorylated Ser383.|
Target Details ELK1Product Details anti-ELK1 Antibody Application Details Handling References for anti-ELK1 antibody (ABIN319099) Images back to top
|Alternative Name||ELK1 (ELK1 Antibody Abstract)|
|Background||ELK-1 is a member of the ternary complex factor (TCF) family of transcription factors, which is thought to play a role in mediating gene expression in response to growth factors. ELK-1 can be phosphorylated at serine 383 and 389 in its C-terminal region in response to the activation of extracellular signal-regulated kinase (ERK) proteins. Phosphorylation of ELK-1 results in an increase in its transcriptional activity, leading to the transcription of growth-related proteins, such as c-Fos.Synonyms: ETS domain-containing protein Elk-1, Elk-1|
|Research Area||Cancer, Transcription Factors|
|Pathways||MAPK Signaling, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades, Signaling of Hepatocyte Growth Factor Receptor|
Application DetailsProduct Details anti-ELK1 Antibody Target Details ELK1 Handling References for anti-ELK1 antibody (ABIN319099) Images back to top
Western Blot: 1: 1000, detects a band of approximately 46 kDa.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-ELK1 Antibody Target Details ELK1 Application Details References for anti-ELK1 antibody (ABIN319099) Images back to top
|Buffer||10 mM HEPES, pH 7.5 containing 0.09 % Sodium Azide, 0.01 % Bovine Serum Albumin and 50 % Glycerol|
|Precaution of Use||This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.|
References for anti-ELK1 antibody (ABIN319099)Product Details anti-ELK1 Antibody Target Details ELK1 Application Details Handling Images back to top
Yang, Yates, Whitmarsh, Davis, Sharrocks: "The Elk-1 ETS-domain transcription factor contains a mitogen-activated protein kinase targeting motif." in: Molecular and cellular biology, Vol. 18, Issue 2, pp. 710-20, 1998