Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Show all species
Show all synonyms
Select your species and application
anti-Human JNK Antibodies:
anti-Mouse (Murine) JNK Antibodies:
anti-Rat (Rattus) JNK Antibodies:
Go to our pre-filtered search.
Cow (Bovine) Polyclonal JNK Primary Antibody for IF (p), IHC (p) - ABIN732368
Rosenzweig, Djap, Ou, Quinn: Mechanical injury of bovine cartilage explants induces depth-dependent, transient changes in MAP kinase activity associated with apoptosis. in Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2012
Show all 12 Pubmed References
Human Polyclonal JNK Primary Antibody for ELISA, ICC - ABIN6255620
Jin, Han, Yang, Hu, Liu, Zhao: 11-O-acetylcyathatriol inhibits MAPK/p38-mediated inflammation in LPS-activated RAW 264.7 macrophages and has a protective effect on ethanol-induced gastric injury. in Molecular medicine reports 2017
Show all 10 Pubmed References
Human Monoclonal JNK Primary Antibody for ICS - ABIN1177076
Fleming, Armstrong, Morrice, Paterson, Goedert, Cohen: Synergistic activation of stress-activated protein kinase 1/c-Jun N-terminal kinase (SAPK1/JNK) isoforms by mitogen-activated protein kinase kinase 4 (MKK4) and MKK7. in The Biochemical journal 2001
Show all 4 Pubmed References
Human Polyclonal JNK Primary Antibody for ELISA, ICC - ABIN6262710
Zou, Xiang, Wang, Peng, Wei: Oregano Essential Oil Improves Intestinal Morphology and Expression of Tight Junction Proteins Associated with Modulation of Selected Intestinal Bacteria and Immune Status in a Pig Model. in BioMed research international 2017
Show all 3 Pubmed References
Human Monoclonal JNK Primary Antibody for ICS - ABIN1177075
Huang, Shi, Chi: Regulation of JNK and p38 MAPK in the immune system: signal integration, propagation and termination. in Cytokine 2009
Show all 3 Pubmed References
Human Polyclonal JNK Primary Antibody for IHC, IHC (p) - ABIN4327961
Gao, Wang, Zhang, Yu, Ji, Wang, Zhang, Jiang, Jin, Huang, Zhang, Li: Tumor necrosis factor receptor-associated factor 5 (Traf5) acts as an essential negative regulator of hepatic steatosis. in Journal of hepatology 2016
Show all 2 Pubmed References
Human Polyclonal JNK Primary Antibody for WB - ABIN3043004
Zheng, Liu, Liu, Ma, Zhou, Chen, Chang, Wang, Yang, He: Cucurbitacin B inhibits growth and induces apoptosis through the JAK2/STAT3 and MAPK pathways in SH?SY5Y human neuroblastoma cells. in Molecular medicine reports 2014
Show all 2 Pubmed References
Caenorhabditis elegans (C. elegans) Polyclonal JNK Primary Antibody for IHC (p), IHC - ABIN151424
Oh, Mukhopadhyay, Svrzikapa, Jiang, Davis, Tissenbaum: JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16. in Proceedings of the National Academy of Sciences of the United States of America 2005
Show all 2 Pubmed References
Human Monoclonal JNK Primary Antibody for WB - ABIN2725437
Sung, Liang, Lee, Yen, Hsiao, Wang, Jiang-Shieh, Tsai, Chen: The protective effect of eupafolin against TNF-?-induced lung inflammation via the reduction of intercellular cell adhesion molecule-1 expression. in Journal of ethnopharmacology 2015
Human Polyclonal JNK Primary Antibody for IF, IHC (p) - ABIN391724
Deng, Ren, Yang, Lin, Wu: A JNK-dependent pathway is required for TNFalpha-induced apoptosis. in Cell 2003
Show all 6 Pubmed References
CXCL12 (show CXCL12 Antibodies) activates the MEKK1 (show MAP3K1 Antibodies)/JNK signaling pathway, which in turn initiates SMAD3 (show SMAD3 Antibodies) phosphorylation, its translocation to nuclei, and recruitment of SMAD3 (show SMAD3 Antibodies) to the CTGF (show CTGF Antibodies) promoter, which ultimately induces CTGF (show CTGF Antibodies) expression in human lung fibroblasts.
Activation of the c-Jun NH2-terminal kinase pathway by coronavirus infectious bronchitis virus promotes apoptosis independently of c-Jun (show JUN Antibodies).
Inhibition of each TGFbeta (show TGFB1 Antibodies) receptor-I, glucocorticoid receptor (show NR3C1 Antibodies) or JNK signaling partially reversed the dexamethasone-mediated effects, suggesting a complex signaling network. These data reveal that dexamethasone mediates progression by membrane effects and binding to glucocorticoid receptor (show NR3C1 Antibodies)
JNK inhibitor prevents SIRT1 (show SIRT1 Antibodies) phosphorylation, leading to elevated SIRT1 (show SIRT1 Antibodies) protein levels even in the presence of H2O2. Taken together, our results indicate that CHFR (show CHFR Antibodies) plays a crucial role in the cellular stress response pathway by controlling the stability and function of SIRT1 (show SIRT1 Antibodies).
Findings suggest that during lipoapoptosis, HCV infection may enhance hepatocyte toxicity by increasing JNK phosphorylation.
High JNK expression is associated with non-small-cell lung cancer.
These data suggested that Annexin A2 (show ANXA2 Antibodies) induces cisplatin resistance of non-small cell lung cancer (NSCLC)via regulation of JNK/c-Jun/p53 (show TP53 Antibodies) signaling, and provided an evidence that blockade of Annexin A2 (show ANXA2 Antibodies) could serve as a novel therapeutic approach for overcoming drug resistance in NSCLCs
Data suggest that H2O2 regulates cell death in granulosa cells via the ROS (show ROS1 Antibodies)-JNK-p53 (show TP53 Antibodies) pathway.
High expression of JNK is associated with invasion of gastric cancer.
JNK activation and signaling in extrahepatic cholangiocarcinoma is regulated by L1CAM.JNK role in cell migration in extrahepatic cholangiocarcinoma.
Findings indicate the MIG-15/JNK-1 pathway can restrict both glutamatergic synapse formation and short-term learning.
Our genetic study unravelled the underlying pathway where JNK-1 is acting independently of insulin (show INS Antibodies)-IGF-1 (show IGF1 Antibodies) signalling (IIS) pathway to modulate longevity. In support of in vivo results in silico docking study of UA with C. elegans JNK-1 ATP-binding site suggested promising binding affinity exhibiting binding energy of -8.11 kcalmol(-1). UA induced JNK-1 activation in wild-type animals underlie the importance of pharmacologi
JNK-1 directly interacts with and phosphorylates DAF-16. Moreover, in response to heat stress, JNK-1 promotes the translocation of DAF-16 into the nucleus.
The present study shows in Caenorhabditis elegans that ambient temperature (1-37 degrees C) specifically influences the activation (phosphorylation) of the MAP kinase JNK-1 as well as the nuclear translocation of DAF-16.
the stress response is controlled by a c-Jun N-terminal kinase (JNK)-like mitogen-activated protein kinase (show MAPK1 Antibodies) (MAPK (show MAPK1 Antibodies)) signaling pathway, which is regulated by MLK-1 (show MAP3K9 Antibodies) MAPK (show MAPK1 Antibodies) kinase kinase (MAPKKK), MEK-1 (show MAP2K1 Antibodies) MAPK (show MAPK1 Antibodies) kinase (MAPKK), and KGB-1 (show KCNJ3 Antibodies) JNK-like MAPK (show MAPK1 Antibodies).
Noise exposure led to enhanced JNK phosphorylation and IRS1 (show IRS1 Antibodies) serine phosphorylation as well as reduced Akt (show AKT1 Antibodies) phosphorylation in skeletal muscles in response to exogenous insulin (show INS Antibodies) stimulation.
Prdx1 (show PRDX1 Antibodies) knockout can aggravate the oxidative stress and lung injury by increasing the level of Reactive Oxygen Species (ROS (show ROS1 Antibodies)), and also activate P38 (show CRK Antibodies)/JNK signaling pathway.
Data identify a unique signal crosstalk between Wnt (show WNT2 Antibodies) signaling and the MAP3K1 (show MAP3K1 Antibodies)-JNK pathway in epithelial morphogenesis.
Therefore, APP (show APP Antibodies) modulates Nav1.6 (show SCN8A Antibodies) sodium channels through a Go-coupled JNK pathway, which is dependent on phosphorylation of APP (show APP Antibodies) at Thr668.
These interactions are required for SRC (show SRC Antibodies)-induced activation of VAV (show VAV1 Antibodies) and the subsequent engagement of a JIP1 (show MAPK8IP1 Antibodies)-tethered JNK signaling module.
this study establishes that JNK1 is a key mediator of osteoblast function in vivo and in vitro.
Jnk1 deficiency inhibits the development of neural stem cells/precursors
Suppressing P38 (show CRK Antibodies) promoted adipogenic trans-differentiation and intensified adipolytic metabolism in differentiated cells. However, inhibition of ERK1/2 had the opposite effects on adipogenesis and no effect on adipolysis. Blocking JNK weakly blocked trans-differentiation but stimulated adipolysis and induced apoptosis.
the effects of JNK1 deficiency in an experimental model of familial Alzheimer's disease, was investigated.
Irradiation coupled with JNK inhibition in beta1 integrin -/- transgenic adenocarcinoma of prostate (TRAMP) leads to increased levels of nuclear focal adhesion kinase (FAK) in tumor cells.
Cell fusion during wound healing in Drosophila larval epidermis occurred primarily in the wound vicinity, where JAK (show JAK3 Antibodies)/STAT (show STAT1 Antibodies) activation was suppressed by fusion-inducing JNK signaling.
aken together, these results reveal that inactivation of Rpd3 (show HDAC1 Antibodies) independently regulates JNK and Yki (show YAP1 Antibodies) activities and that both Hippo and JNK signaling pathways contribute to Rpd3 (show HDAC1 Antibodies) RNAi-induced apoptosis.
Data show that JNK signalling inhibits the growth of losers, while JAK (show JAK3 Antibodies)/STAT (show STAT1 Antibodies) signalling promotes competition-induced winner cell proliferation.
Here we uncover a cell non-autonomous requirement for the Epidermal growth factor receptor (Egfr (show EGFR Antibodies)) pathway in the lateral epidermis for sustained dpp (show TGFb Antibodies) expression in the LE. Specifically, we demonstrate that Egfr (show EGFR Antibodies) pathway activity in the lateral epidermis prevents expression of the gene scarface (scaf), encoding a secreted antagonist of JNK signaling
n addition to significantly increasing the number of JNK target genes identified so far, our results reveal that the LE is a highly heterogeneous morphogenetic organizer, sculpted through crosstalk between JNK, segmental and AP signalling. This fine-tuning regulatory mechanism is essential to coordinate morphogenesis and dynamics of tissue sealing
malignant transformation of the ras(V12)scrib(1 (show SCRIB Antibodies)) tumors requires bZIP protein Fos, the ETS (show ETS1 Antibodies)-domain factor Ets21c and the nuclear receptor Ftz-F1 (show NR5A2 Antibodies), all acting downstream of Jun-N-terminal kinase.
Diminished MTORC1-dependent JNK activation underlies the neurodevelopmental defects associated with lysosomal dysfunction.
ROS (show ROS1 Antibodies)/JNK/p38 (show MAPK14 Antibodies)/Upd (show UROD Antibodies) stress responsive module restores tissue homeostasis. This module is not only activated after cell death induction but also after physical damage and reveals one of the earliest responses for imaginal disc regeneration.
Significantly, the JNK pathway is responsible for the majority of the phenotypes and transcriptional changes downstream of Notch (show NOTCH1 Antibodies)-Src (show SRC Antibodies) synergy.
This study demonstrated that the mechanism by which Bsk (show FRK Antibodies) is required for pruning is through reducing the membrane levels of the adhesion molecule (show NCAM1 Antibodies) Fasciclin II (show NCAM2 Antibodies) (FasII)
Porcine reproductive and respiratory syndrome virus -activated TAK-1 (show NR2C2 Antibodies) was essential for the activation of JNK and NF-kappaB (show NFKB1 Antibodies) pathways and IL-8 (show IL8 Antibodies) expression.
Data show that proinflammatory cytokines induction was ERK1/2 and JNK1/2 dependent.
These data suggest that the p38 (show MAPK14 Antibodies) and JNK signaling pathways play pivotal roles in PRRSV replication and may regulate immune responses during virus infection.
based on the data, we can conclude that JNK plays an active role in fragmentation of pig oocytes and that p38 MAPK (show MAPK14 Antibodies) is not involved in this process
Retinal ischemia-reperfusion alters expression of mitogen-activated protein kinases, particularly ERK1/2, in the neuroretina and retinal arteries.
PP2A (show PPP2R2B Antibodies) and AIP1 (show PDCD6IP Antibodies) cooperatively induce activation of ASK1 (show MAP3K5 Antibodies)-JNK signaling and vascular endothelial cell apoptosis.
Phorbol 12-myristate 13-acetate activation of ERK (show MAPK1 Antibodies) and JNK signaling is relevant in the regulation of gene expression during follicular development, ovulation, and luteinization.
study reports MPK8 connects protein phosphorylation, Ca(2 (show CA2 Antibodies))+ and ROS (show ROS1 Antibodies) in wound-signaling pathway; suggests 2 major activation modes, Ca(2 (show CA2 Antibodies))+/CaMs and MAP kinase (show MAPK1 Antibodies) phosphorylation cascade, converge at MPK8 to monitor or maintain an essential part of ROS (show ROS1 Antibodies) homeostasis
The results of this study suggest that JNK has a role in the disassembly adherens junctions by means of endocytosis that is required during buccopharyngeal membrane perforation.
Hyperosmotic Shock Engages Two Positive Feedback Loops through Caspase-3 (show CASP3 Antibodies)-dependent Proteolysis of JNK1-2 and Bid (show BID Antibodies).
JNK signaling is required to establish microtubule stability and maintain tissue cohesion in the gut (show GUSB Antibodies).
Data show that the death pathway is independent of ERK (show MAPK1 Antibodies) but relies on activating Bad phosphorylation through the control of both kinases Cdk1 (show CDK1 Antibodies) and JNK.
our data provide strong evidence that Jip3 in fact serves as an adapter protein linking these cargos to dynein
P38 (show MAPK14 Antibodies) and JNK have opposing effects on persistence of in vivo leukocyte migration in zebrafish.
A dorsalization pathway that is exerted by Axin (show AXIN1 Antibodies)/JNK signaling and its inhibitor Aida (show AIDA Antibodies) during vertebrate embryogenesis, is defined.
JNK-Mmp13 (show MMP13 Antibodies) signaling pathway plays an essential role in regulating the innate immune cell migration in response to severe injury in vivo
Suggest that hypoxia-induced modified cells engage the PDGFbeta-R-JNK1 axis to confer distinctively heightened proliferation and adventitial remodelling in pulmonary hypertension.
These data suggest a differential requirement of JNK1 and p38 MAPK (show MAPK14 Antibodies) in TNF (show TNF Antibodies) regulation of E2F1 (show E2F1 Antibodies). Targeted inactivation of JNK1 at arterial injury sites may represent a potential therapeutic intervention for ameliorating TNF (show TNF Antibodies)-mediated EC dysfunction.
PKD (show PRKD1 Antibodies) is a critical mediator in H2O2- but not TNF (show TNF Antibodies)-induced ASK1 (show MAP3K5 Antibodies)-JNK signaling
ATF3 (show ATF3 Antibodies) induction by acute hypoxia is mediated by nitric oxide and the JNK pathway in endothelial cells
JNK plays an important role in the induction of apoptosis in transformed bovine brain endothelial cells stimulated by LPS (show IRF6 Antibodies)
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
JUN N-terminal kinase
, MAP kinase 8
, c-Jun N-terminal kinase 1
, mitogen-activated protein kinase 8 isoform JNK1 alpha1
, mitogen-activated protein kinase 8 isoform JNK1 beta2
, stress-activated protein kinase 1
, stress-activated protein kinase 1c
, JNK1 beta1 protein kinase
, MAPK 8
, mitogen activated protein kinase 8
, protein kinase mitogen-activated 8
, stress-activated protein kinase JNK1
, SAPK gamma
, c-jun NH2-terminal kinase
, p54 gamma
, JUN kinase
, Jun N-terminal kinase
, Jun NH2-terminal kinase
, Jun-N-terminal kinase
, c-Jun N-terminal kinase
, c-Jun aminoterminal kinase
, c-Jun-N-terminal kinase
, drosophila JNK
, janus kinase 1
, mitogen-activated protein kinase 8
, LOW QUALITY PROTEIN: mitogen-activated protein kinase 8B-like
, MAP kinase 8B
, MAPK 8B
, Mitogen-activated protein kinase 8B
, Stress-activated protein kinase JNKb
, c-Jun N-terminal kinase B