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anti-Human JNK Antibodies:
anti-Mouse (Murine) JNK Antibodies:
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Cow (Bovine) Polyclonal JNK Primary Antibody for IF (p), IHC (p) - ABIN732368
Rosenzweig, Djap, Ou, Quinn: Mechanical injury of bovine cartilage explants induces depth-dependent, transient changes in MAP kinase activity associated with apoptosis. in Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2012
Show all 11 Pubmed References
Human Monoclonal JNK Primary Antibody for IP, WB - ABIN967330
Adler, Fuchs, Kim, Kraft, King, Pelling, Ronai: jun-NH2-terminal kinase activation mediated by UV-induced DNA lesions in melanoma and fibroblast cells. in Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1996
Show all 7 Pubmed References
Human Monoclonal JNK Primary Antibody for FACS, WB - ABIN968867
Fleming, Armstrong, Morrice, Paterson, Goedert, Cohen: Synergistic activation of stress-activated protein kinase 1/c-Jun N-terminal kinase (SAPK1/JNK) isoforms by mitogen-activated protein kinase kinase 4 (MKK4) and MKK7. in The Biochemical journal 2001
Show all 5 Pubmed References
Human Monoclonal JNK Primary Antibody for FACS, WB - ABIN968866
Kyriakis, Avruch: Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. in Physiological reviews 2001
Show all 4 Pubmed References
Human Monoclonal JNK Primary Antibody for ICS - ABIN1177076
Huang, Shi, Chi: Regulation of JNK and p38 MAPK in the immune system: signal integration, propagation and termination. in Cytokine 2009
Show all 4 Pubmed References
Human Monoclonal JNK Primary Antibody for ICS - ABIN1177075
Wagner, Nebreda: Signal integration by JNK and p38 MAPK pathways in cancer development. in Nature reviews. Cancer 2009
Show all 3 Pubmed References
Human Polyclonal JNK Primary Antibody for IHC, IHC (p) - ABIN4327961
Gao, Wang, Zhang, Yu, Ji, Wang, Zhang, Jiang, Jin, Huang, Zhang, Li: Tumor necrosis factor receptor-associated factor 5 (Traf5) acts as an essential negative regulator of hepatic steatosis. in Journal of hepatology 2016
Show all 2 Pubmed References
Caenorhabditis elegans (C. elegans) Polyclonal JNK Primary Antibody for IHC (p), IHC - ABIN151424
Oh, Mukhopadhyay, Svrzikapa, Jiang, Davis, Tissenbaum: JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16. in Proceedings of the National Academy of Sciences of the United States of America 2005
Show all 2 Pubmed References
Human Polyclonal JNK Primary Antibody for WB - ABIN3043004
Zheng, Liu, Liu, Ma, Zhou, Chen, Chang, Wang, Yang, He: Cucurbitacin B inhibits growth and induces apoptosis through the JAK2/STAT3 and MAPK pathways in SH?SY5Y human neuroblastoma cells. in Molecular medicine reports 2014
Show all 2 Pubmed References
Human Polyclonal JNK Primary Antibody for ICC, IF - ABIN4327964
Tian, Guo, Liu, Liu, Weng, Dong, Knowlton, Yuan, Lin: Extracellular HSP60 induces inflammation through activating and up-regulating TLRs in cardiomyocytes. in Cardiovascular research 2013
aken together, these results reveal that inactivation of Rpd3 (show HDAC1 Antibodies) independently regulates JNK and Yki (show YAP1 Antibodies) activities and that both Hippo and JNK signaling pathways contribute to Rpd3 (show HDAC1 Antibodies) RNAi-induced apoptosis.
Data show that JNK signalling inhibits the growth of losers, while JAK (show JAK3 Antibodies)/STAT (show STAT1 Antibodies) signalling promotes competition-induced winner cell proliferation.
Here we uncover a cell non-autonomous requirement for the Epidermal growth factor receptor (Egfr (show EGFR Antibodies)) pathway in the lateral epidermis for sustained dpp (show TGFb Antibodies) expression in the LE. Specifically, we demonstrate that Egfr (show EGFR Antibodies) pathway activity in the lateral epidermis prevents expression of the gene scarface (scaf), encoding a secreted antagonist of JNK signaling
n addition to significantly increasing the number of JNK target genes identified so far, our results reveal that the LE is a highly heterogeneous morphogenetic organizer, sculpted through crosstalk between JNK, segmental and AP signalling. This fine-tuning regulatory mechanism is essential to coordinate morphogenesis and dynamics of tissue sealing
malignant transformation of the ras(V12)scrib(1 (show SCRIB Antibodies)) tumors requires bZIP protein Fos, the ETS (show ETS1 Antibodies)-domain factor Ets21c and the nuclear receptor Ftz-F1 (show NR5A2 Antibodies), all acting downstream of Jun-N-terminal kinase.
Diminished MTORC1-dependent JNK activation underlies the neurodevelopmental defects associated with lysosomal dysfunction.
ROS (show ROS1 Antibodies)/JNK/p38 (show MAPK14 Antibodies)/Upd (show UROD Antibodies) stress responsive module restores tissue homeostasis. This module is not only activated after cell death induction but also after physical damage and reveals one of the earliest responses for imaginal disc regeneration.
Significantly, the JNK pathway is responsible for the majority of the phenotypes and transcriptional changes downstream of Notch (show NOTCH1 Antibodies)-Src (show SRC Antibodies) synergy.
This study demonstrated that the mechanism by which Bsk (show FRK Antibodies) is required for pruning is through reducing the membrane levels of the adhesion molecule (show NCAM1 Antibodies) Fasciclin II (show NCAM2 Antibodies) (FasII)
Study solves the crystal structure of unphosphorylated DJNK in complex with adenylyl imidodiphosphate (AMP (show AMPH Antibodies)-PNP (show NP Antibodies)) and magnesium.
ERK1 (show MAPK3 Antibodies) Directly Interacts With JNK1 Leading to Regulation of JNK1/c-Jun (show JUN Antibodies) Activity and Cell Transformation.
TGM2 (show TGM2 Antibodies) is involved in amyloid-beta (1-42)-induced pro-inflammatory activation via AP1 (show FOSB Antibodies)/JNK signaling pathways in cultured monocytes.
NleL-induced JNK ubiquitylation, particularly mono-ubiquitylation at the Lys (show LYZ Antibodies) 68 residue of JNK, impairs JNK's interaction with an upstream kinase MKK7 (show MAP2K7 Antibodies), thus disrupting JNK phosphorylation and activation.
The surface immune molecule CD274 (show CD274 Antibodies) plays a critical role in the proliferation of leukemia-initiating cells, LICs. The CD274 (show CD274 Antibodies)/JNK/Cyclin D2 (show CCND2 Antibodies) pathway promotes the cell cycle entry of LIC.
These data implicate HTRA1 (show HTRA1 Antibodies) as a negative regulator of mesenchymal stem cell adipogenesis.
Our findings indicate that GADD45 (show GADD45A Antibodies) essentially suppresses the MKK7 (show MAP2K7 Antibodies)-JNK pathway and suggest that differentially expressed GADD45 (show GADD45A Antibodies) family members fine-tune stress-inducible JNK activity.
Quantitative phosphoproteomic analysis identifies the critical role of JNK1 in neuroinflammation induced by Japanese encephalitis virus
post-translational modification facilitates the mobilization of SIRT6 (show SIRT6 Antibodies) to DNA damage sites and is required for efficient recruitment of poly (ADP-ribose) polymerase 1 (PARP1 (show PARP1 Antibodies)) to DNA break sites and for efficient repair of double-strand break.
PRDM5 (show PRDM5 Antibodies) promotes the proliferation and invasion of murine melanoma cells through up-regulating JNK expression and strategies targeting PRDM5 (show PRDM5 Antibodies) may be promising for the therapy of melanoma.
This study showed that the induction level of IL-32 (show IL32 Antibodies) was increased in chronic rhinosinusitis with nasal polyps compared to normal nasal mucosa and that LPS (show IRF6 Antibodies)-induced IL-32 (show IL32 Antibodies) expression in nasal polyp-derived fibroblasts was regulated via the TLR4 (show TLR4 Antibodies)/JNK/AKT (show AKT1 Antibodies)/CREB (show CREB1 Antibodies) signaling pathway.
the effects of JNK1 deficiency in an experimental model of familial Alzheimer's disease, was investigated.
Irradiation coupled with JNK inhibition in beta1 integrin -/- transgenic adenocarcinoma of prostate (TRAMP) leads to increased levels of nuclear focal adhesion kinase (FAK) in tumor cells.
transgenic mice overexpressing sPLA2 -IIA (show PLA2G2A Antibodies) keratinocytes showed enhanced activation of EGFR (show EGFR Antibodies) and JNK1/2 that led to c-Jun (show JUN Antibodies) activation.
p53 (show TP53 Antibodies) plays a novel protective role in APAP induced liver injury through inhibiting the activation of JNK, a key mediator in APAP-induced oxidative stress.
We crossed Ptf1a (show PTF1A Antibodies)(Cre/+) ;Kras(G12D/+) mice with JNK1(-/-) mice to generate Ptf1a (show PTF1A Antibodies)(Cre/+) ;Kras(G12D/+) ;JNK1(-/-) (Kras;JNK1(-/-) ) mice. Tumor weight was significantly lower in Kras;JNK1(-/-) mice than in Kras;JNK1(+/-) mice, whereas histopathological features were similar.we concluded that inhibition of activated JNK in pancreatic tumor stroma could be a potential therapeutic target to increase Ccl20 (show CCL20 Antibodies) secretion
BOC (show BOC Antibodies) interacts with ABL (show ABL1 Antibodies) and activates JNK thereby promoting neuronal differentiation and neurite outgrowth.
The authors have found that JNK signaling is required for proper vascular morphogenesis and the normal formation of collateral arteries in muscle.
JNK1-mediated NLRP3 (show NLRP3 Antibodies) phosphorylation at S194 is a critical priming event and is essential for NLRP3 (show NLRP3 Antibodies) inflammasome activation.
The results of this study suggest that JNK has a role in the disassembly adherens junctions by means of endocytosis that is required during buccopharyngeal membrane perforation.
Hyperosmotic Shock Engages Two Positive Feedback Loops through Caspase-3 (show CASP3 Antibodies)-dependent Proteolysis of JNK1-2 and Bid (show BID Antibodies).
JNK signaling is required to establish microtubule stability and maintain tissue cohesion in the gut (show GUSB Antibodies).
Data show that the death pathway is independent of ERK (show MAPK1 Antibodies) but relies on activating Bad phosphorylation through the control of both kinases Cdk1 (show CDK1 Antibodies) and JNK.
study reports MPK8 connects protein phosphorylation, Ca(2 (show CA2 Antibodies))+ and ROS (show ROS1 Antibodies) in wound-signaling pathway; suggests 2 major activation modes, Ca(2 (show CA2 Antibodies))+/CaMs and MAP kinase (show MAPK1 Antibodies) phosphorylation cascade, converge at MPK8 to monitor or maintain an essential part of ROS (show ROS1 Antibodies) homeostasis
our data provide strong evidence that Jip3 in fact serves as an adapter protein linking these cargos to dynein
P38 (show MAPK14 Antibodies) and JNK have opposing effects on persistence of in vivo leukocyte migration in zebrafish.
A dorsalization pathway that is exerted by Axin (show AXIN1 Antibodies)/JNK signaling and its inhibitor Aida (show AIDA Antibodies) during vertebrate embryogenesis, is defined.
JNK-Mmp13 (show MMP13 Antibodies) signaling pathway plays an essential role in regulating the innate immune cell migration in response to severe injury in vivo
Our genetic study unravelled the underlying pathway where JNK-1 is acting independently of insulin (show INS Antibodies)-IGF-1 (show IGF1 Antibodies) signalling (IIS) pathway to modulate longevity. In support of in vivo results in silico docking study of UA with C. elegans JNK-1 ATP-binding site suggested promising binding affinity exhibiting binding energy of -8.11 kcalmol(-1). UA induced JNK-1 activation in wild-type animals underlie the importance of pharmacologi
JNK-1 directly interacts with and phosphorylates DAF-16. Moreover, in response to heat stress, JNK-1 promotes the translocation of DAF-16 into the nucleus.
The present study shows in Caenorhabditis elegans that ambient temperature (1-37 degrees C) specifically influences the activation (phosphorylation) of the MAP kinase JNK-1 as well as the nuclear translocation of DAF-16.
the stress response is controlled by a c-Jun N-terminal kinase (JNK)-like mitogen-activated protein kinase (show MAPK1 Antibodies) (MAPK (show MAPK1 Antibodies)) signaling pathway, which is regulated by MLK-1 (show MAP3K9 Antibodies) MAPK (show MAPK1 Antibodies) kinase kinase (MAPKKK), MEK-1 (show MAP2K1 Antibodies) MAPK (show MAPK1 Antibodies) kinase (MAPKK), and KGB-1 (show KCNJ3 Antibodies) JNK-like MAPK (show MAPK1 Antibodies).
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
, JUN kinase
, Jun N-terminal kinase
, Jun NH2-terminal kinase
, Jun-N-terminal kinase
, c-Jun N-terminal kinase
, c-Jun aminoterminal kinase
, c-Jun-N-terminal kinase
, drosophila JNK
, JUN N-terminal kinase
, MAP kinase 8
, c-Jun N-terminal kinase 1
, mitogen-activated protein kinase 8 isoform JNK1 alpha1
, mitogen-activated protein kinase 8 isoform JNK1 beta2
, stress-activated protein kinase 1
, stress-activated protein kinase 1c
, JNK1 beta1 protein kinase
, MAPK 8
, mitogen activated protein kinase 8
, protein kinase mitogen-activated 8
, stress-activated protein kinase JNK1
, SAPK gamma
, c-jun NH2-terminal kinase
, p54 gamma
, mitogen-activated protein kinase 8