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Submit your validation data for this product and get a full refund. I want to validate this productRelevance Score | ABIN | Application | Conjugate | Host | Isotype | Epitope | Supplier | Clonality | References | Details |
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12.833679 | ABIN4327964 | ICC IF IHC IHC (p) WB | Rabbit | Log in to see | Polyclonal | 1 | ||||
12.833679 | ABIN747713 | IF (p) IHC (p) WB | Rabbit | IgG | AA 160-210 | Log in to see | Polyclonal | 1 | ||
12.833679 | ABIN462091 | IHC (p) WB | Rabbit | N-Term | Log in to see | Polyclonal | 0 | |||
12.833679 | ABIN498747 | IF IHC (p) WB | Rabbit | pThr183 | Log in to see | Polyclonal | 0 | |||
12.833679 | ABIN498627 | IF IHC (p) WB | Rabbit | Log in to see | Polyclonal | 0 | ||||
12.833679 | ABIN498628 | IHC (p) WB | Rabbit | Log in to see | Polyclonal | 0 | ||||
12.833679 | ABIN498285 | IF IHC (p) WB | Rabbit | Log in to see | Polyclonal | 0 | ||||
1 | ABIN732368 | IF (p) IHC (p) WB | Rabbit | IgG | AA 170-210, pThr183, pTyr185 | Log in to see | Polyclonal | 12 | ||
1 | ABIN2854959 | ICC IF IHC (p) WB | Rabbit | IgG | Center | Log in to see | Polyclonal | 0 | ||
1 | ABIN654887 | IHC (p) WB | Rabbit | Ig Fraction | AA 159-195, Thr183, Tyr185 | Log in to see | Polyclonal | 3 | ||
1 | ABIN4327961 | IHC IHC (p) WB | Rabbit | pThr183 | Log in to see | Polyclonal | 2 | |||
1 | ABIN3042709 | ICC IHC (p) WB | Rabbit | IgG | AA 344-363, Middle Region | Log in to see | Polyclonal | 0 | ||
1 | ABIN127312 | IHC (p) IP WB | Rabbit | C-Term | Log in to see | Polyclonal | 0 | |||
1 | ABIN2878886 | IF IHC (p) ELISA WB | Rabbit | IgG | AA 166-215 | Log in to see | Polyclonal | 0 | ||
1 | ABIN747722 | IHC (p) WB | HRP | Rabbit | IgG | AA 160-210 | Log in to see | Polyclonal | 0 | |
1 | ABIN732377 | IHC (p) WB | HRP | Rabbit | IgG | AA 170-210, pThr183, pTyr185 | Log in to see | Polyclonal | 0 | |
1 | ABIN2625183 | ICC IHC (p) WB | Rabbit | IgG | AA 344-363 | Log in to see | Polyclonal | 0 | ||
1 | ABIN747715 | IHC (p) WB | Biotin | Rabbit | IgG | AA 160-210 | Log in to see | Polyclonal | 0 | |
1 | ABIN732370 | IHC (p) WB | Biotin | Rabbit | IgG | AA 170-210, pThr183, pTyr185 | Log in to see | Polyclonal | 0 | |
1 | ABIN2177531 | IHC (p) WB | HRP | Rabbit | IgG | pThr183, pTyr185 | Log in to see | Polyclonal | 0 |
General |
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Antigen | Mitogen-Activated Protein Kinase 8 (MAPK8) Antibodies |
Epitope | AA 162-199 Alternatives |
Reactivity | Human, Mouse (Murine) Alternatives |
Host | Rabbit Alternatives |
Clonality | |
Conjugate | This JNK antibody is un-conjugated Alternatives |
Application |
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
Alternatives
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5 references available |
Supplier | Log in to see |
Product Details anti-JNK AntibodyTarget Details JNK Application Details Handling References for anti-JNK antibody (ABIN953314) Images |
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Specificity | This antibody recognizes Human and Mouse MAPK8 / JNK1 (Thr183/Tyr185). |
Purification | Protein A column, followed by peptide affinity purification |
Immunogen | KLH conjugated synthetic peptide between 162-199 amino acids from human MAPK8 / JNK1 |
Isotype | Ig Fraction |
Target Details JNKProduct Details anti-JNK Antibody Application Details Handling References for anti-JNK antibody (ABIN953314) Images back to top |
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Antigen | |
Alternative Name | MAPK8 / JNK1 (MAPK8 Antibody Abstract) |
Background | The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.Synonyms: JNK-1, JNK-46, Mitogen-activated protein kinase 8, PRKM8, Stress-activated protein kinase JNK1, c-Jun N-terminal kinase 1 |
Molecular Weight | 48296 Da |
Gene ID | 5599 |
NCBI Accession | NP_002741 |
Pathways | MAPK Signaling, WNT Signaling, TLR Signaling, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades, Signaling of Hepatocyte Growth Factor Receptor |
Application DetailsProduct Details anti-JNK Antibody Target Details JNK Handling References for anti-JNK antibody (ABIN953314) Images back to top |
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Application Notes | Optimal working dilution should be determined by the investigator. |
Restrictions | For Research Use only |
HandlingProduct Details anti-JNK Antibody Target Details JNK Application Details References for anti-JNK antibody (ABIN953314) Images back to top |
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Format | Liquid |
Concentration | 0.25 mg/mL |
Buffer | PBS containing 0.09 % (W/V) Sodium Azide as preservative |
Preservative | Sodium azide |
Precaution of Use | This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only. |
Handling Advice | Avoid repeated freezing and thawing. |
Storage | 4 °C/-20 °C |
Storage Comment | Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. |
References for anti-JNK antibody (ABIN953314)Product Details anti-JNK Antibody Target Details JNK Application Details Handling Images back to top |
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Background publications |
Dasgupta, Kar, Liu, Joseph, Kalyanaraman, Remington, Chen, Melendez: "Reactive oxygen species control senescence-associated matrix metalloproteinase-1 through c-Jun-N-terminal kinase." in: Journal of cellular physiology, Vol. 225, Issue 1, pp. 52-62, 2010 Gao, Nong, Huang, Lu, Zhao, Lin, Man, Wang, Yang, Li: "The effects of palmitate on hepatic insulin resistance are mediated by NADPH Oxidase 3-derived reactive oxygen species through JNK and p38MAPK pathways." in: The Journal of biological chemistry, Vol. 285, Issue 39, pp. 29965-73, 2010 Han, Crowe: "Jun amino-terminal kinase 1 activation promotes cell survival in ErbB2-positive breast cancer." in: Anticancer research, Vol. 30, Issue 9, pp. 3407-12, 2010 Yang, Zheng, Cao, Xiang, Liu, Lv: "8-Bromo-7-methoxychrysin-induced apoptosis of hepatocellular carcinoma cells involves ROS and JNK." in: World journal of gastroenterology : WJG, Vol. 16, Issue 27, pp. 3385-93, 2010 Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 |
ImagesProduct Details anti-JNK Antibody Target Details JNK Application Details Handling References for anti-JNK antibody (ABIN953314) back to top |
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Supplier Images |