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Report a synthetic lethal interaction of cetuximab in combination with MEK1 (show MAP2K1 Proteins)/2 inhibition for the NRAS (show NRAS Proteins) mutant subgroup of metastatic colorectal cancer.
There are no other biomarkers correlated with treatment responses following MEK1 (show MAP2K1 Proteins)/2 inhibition.
MEK2 was essential for the phosphorylation of MKK3 (show MAP2K3 Proteins)/MKK6 (show MAP2K6 Proteins) and p38 MAPK (show MAPK14 Proteins) that directly impacted on cyclin D1 (show CCND1 Proteins) expression.
High MEK2 expression is associated with inflammation.
there were significant decreases in intercellular adhesion molecules 1 (ICAM1 (show ICAM1 Proteins)), ezrin (EZR (show EZR Proteins)), mitogen-activated protein kinase kinase 2 (MAP2K2), and nitric oxide synthase 3 (NOS3 (show NANOS3 Proteins)) gene expressions in metabolic syndrome patients.
The patient showed a paternally inherited 16p13.11 microduplication and a de novo 19p13.3 microdeletion involving the mitogen-activated protein kinase kinase 2 gene (MAP2K2), in which mutations cause the cardio-facio-cutaneous (CFC (show PTPN11 Proteins)) syndrome
Data show that mitogen-activated protein kinase (show MAPK1 Proteins) kinases MEK1 (show MAP2K1 Proteins)/2 inhibitor pimasertib (MEKI) sensitized the cells to apoptosis through its ability to promote a G1 cell cycle arrest.
the purpose of this paper was to investigate MAPK (show MAPK1 Proteins) downstream signalling molecules in Natural killer cell phenotypes from Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients.
at clinically relevant concentrations, cDDP binds to and inhibits MEK1 (show MAP2K1 Proteins)/2 and both the binding and inhibitory activity are related to its interaction with Cu bound to MEK1 (show MAP2K1 Proteins)/2
Endocytosis separates EGF (show EGF Proteins) receptors from endogenous fluorescently labeled HRas (show HRAS Proteins) and diminishes receptor signaling to MAP kinases in endosomes.
data suggest that, although short-term suppression of Mek1 (show MAP2K1 Proteins)/2 in ES cells helps to maintain an inner cell mass-like epigenetic state, prolonged suppression results in irreversible changes that compromise their developmental potential
Erk5 MAP kinase is activated in response to PDGF-BB in the smooth muscle cell line MOVAS in a manner dependent on Mekk2, Mek1/2, Mek5, PI3-kinase and protein kinase C (PKC).
fluid shear stress induces autocrine TGF-beta (show TGFB1 Proteins)/ALK5 (show TGFBR1 Proteins)-induced target gene expression in renal epithelial cells, which is partially restrained by MEK1 (show MAP2K1 Proteins)/2-mediated signaling.
FGF2 (show FGF2 Proteins) is an extracellular inducer of COUP-TFII (show NR2F2 Proteins) expression and may suppress the osteogenic potential of mesenchymal cells by inducing COUP-TFII (show NR2F2 Proteins) expression prior to the onset of osteogenic differentiation
REDD1 (show DDIT4 Proteins) is required for normal insulin (show INS Proteins)-stimulated signaling, and a subtle balance exists between MEK1 (show MAP2K1 Proteins)/2, REDD1 (show DDIT4 Proteins), and mTOR (show FRAP1 Proteins)
MEK1 (show MAP2K1 Proteins) and MEK2 can substitute for each other but a minimum amount of MEK (show MDK Proteins) is critical for placenta development and embryo survival
MK2 (show KCNA2 Proteins)/3 cascade plays a strategic role in controlling synaptic plasticity and cognition.
MK2 (show KCNA2 Proteins) attenuates dendritic cell-mediated Th1 (show HAND1 Proteins) differentiation and autoimmune encephalomyelitis.
analysis of p38 (show CRK Proteins)-MK2 (show KCNA2 Proteins)-activated Rsk (show RPS6KA1 Proteins) signaling in toll (show TLR4 Proteins)-like receptor-stimulated dendritic cells
both MEK1 (show MAP2K1 Proteins) and MEK2 have crucial roles in the integration of mesenchymal and epithelial signals essential for the development of the entire respiratory tract
the AtMKK2-AtMPK10 (show MAPK10 Proteins) MAPK (show MAPK1 Proteins) module regulates leaf venation complexity by altering polar auxin transport efficiency
Treatment of Arabidopsis with a membrane rigidifier, DMSO, causes MPK4 (show MAPK4 Proteins) activation concomitantly with MEKK1 (show MAP3K1 Proteins) and MKK2 phosphorylation.
Ca(2 (show CA2 Proteins)+) signaling occurred upstream of the MEKK1 (show MAP3K1 Proteins)-MKK2 pathway. MEKK1 (show MAP3K1 Proteins) was phosphorylated by calcium/calmodulin-regulated receptor-like kinase (CRLK1), which suggested that CRLK1 is one of candidates located upstream of MEKK1 (show MAP3K1 Proteins).
Data indicate that MEKK2 (show MAP3K2 Proteins) is required for the mekk1 (show MAP3K1 Proteins), mkk1 (show MAP2K1 Proteins) mkk2, and mpk4 (show MAPK4 Proteins) autoimmune phenotypes.
Data suggest that the MEKK1 (show MAP3K1 Proteins)-MKK1 (show MAP2K1 Proteins)/MKK2-MPK4 (show MAPK4 Proteins) kinase cascade negatively regulates MEKK2 (show MAP3K2 Proteins) and activation of MEKK2 (show MAP3K2 Proteins) triggers SUMM2-mediated immune responses.
Data indicate that MKK2 plays a role in abiotic stress tolerance and plant disease resistance.
double loss-of-function mutant (mkk1 (show MAP2K1 Proteins)/2) of MKK1 (show MAP2K1 Proteins) and MKK2 is shown to have marked phenotypes in development and disease
Activation of MPK4 (show MAPK4 Proteins) by flg22 is impaired in the mkk1 (show MAP2K1 Proteins) mkk2 double mutants, suggesting that MKK1 (show MAP2K1 Proteins) and MKK2 function together with MPK4 (show MAPK4 Proteins) and MEKK1 (show MAP3K1 Proteins) in a MAP kinase (show MAPK1 Proteins) cascade to negatively regulate innate immune responses in plants.
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene.
ERK activator kinase 2
, MAP kinase kinase 2
, MAPK/ERK kinase 2
, MAPKK 2
, MEK 2
, dual specificity mitogen-activated protein kinase kinase 2
, mitogen-activated protein kinase kinase 2, p45
, MAP kinase/Erk kinase
, mitogen activated protein kinase kinase 2
, protein kinase, mitogen activated, kinase 2, p45
, dual specificity mitogen activated protein kinase kinase 2
, mitogen-activated protein kinase kinase type 2