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|Antigen||Mitogen-Activated Protein Kinase Kinase 5 (MAP2K5) Antibodies|
|Epitope||AA 380-430 Alternatives|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This MAP2K5 antibody is un-conjugated Alternatives|
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
|2 references available|
|Supplier||Log in to see|
Product Details anti-MAP2K5 AntibodyTarget Details MAP2K5 Application Details Handling References for anti-MAP2K5 antibody (ABIN754183) Images
|Purification||Purified by Protein A.|
|Immunogen||KLH conjugated synthetic peptide derived from human MEK5|
Target Details MAP2K5Product Details anti-MAP2K5 Antibody Application Details Handling References for anti-MAP2K5 antibody (ABIN754183) Images back to top
|Alternative Name||Mek5 (MAP2K5 Antibody Abstract)|
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signaling for determination of cell fate such as differentiation and survival. Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation. MAP3K5/ASK1 is required for the innate immune response, which is essential for host defense against a wide range of pathogens. Mediates signal transduction of various stressors like oxidative stress as well as by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF) or lipopolysaccharide (LPS). Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K4/SEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases (JNKs). Both p38 MAPK and JNKs control the transcription factors activator protein-1 (AP-1).
Subcellular location: Cytoplasm, Nucleus
Synonyms: MEK5, MAPKK5, Dual specificity mitogen-activated protein kinase kinase 5, MAPK/ERK kinase 5, MEK 5, MAP2K5, MAP kinase kinase 5
|Pathways||MAPK Signaling, Neurotrophin Signaling Pathway|
Application DetailsProduct Details anti-MAP2K5 Antibody Target Details MAP2K5 Handling References for anti-MAP2K5 antibody (ABIN754183) Images back to top
|Restrictions||For Research Use only|
HandlingProduct Details anti-MAP2K5 Antibody Target Details MAP2K5 Application Details References for anti-MAP2K5 antibody (ABIN754183) Images back to top
|Buffer||Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.|
|Storage Comment||Store at -20°C|
|Expiry Date||12 months|
References for anti-MAP2K5 antibody (ABIN754183)Product Details anti-MAP2K5 Antibody Target Details MAP2K5 Application Details Handling Images back to top
|Product cited in:||
Chen, Hou, Ye, Chen, Cui, Tian, Li, Liu: "MicroRNA-143 regulates adipogenesis by modulating the MAP2K5-ERK5 signaling." in: Scientific reports, Vol. 4, pp. 3819, 2014 Method employed by authors: Western Blotting (WB) (Sample species: Rat (Rattus)).
Li, Dong, Wei, Wang, Zhang, Li: "Fatty acid synthase mediates the epithelial-mesenchymal transition of breast cancer cells." in: International journal of biological sciences, Vol. 10, Issue 2, pp. 171-80, 2014 Method employed by authors: Western Blotting (WB) (Sample species: Human).
ImagesProduct Details anti-MAP2K5 Antibody Target Details MAP2K5 Application Details Handling References for anti-MAP2K5 antibody (ABIN754183) back to top
|Positive Control||Human breast myoepithelial and glandular tissue|
|Negative Control||Human breast adipose tissue|
|Notes||Strong signal was detected in positive control sample, with minor background seen in negative control sample.|
|Isotype Control Antibody|