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acts as a repressor of UCP1 (show UCP1 Proteins) expression, suggesting that its inhibition promotes adipose tissue browning and increases organismal energy expenditure
MEK2 (show MAP2K2 Proteins) was essential for the phosphorylation of MKK3 (show MAP2K3 Proteins)/MKK6 and p38 MAPK (show MAPK14 Proteins) that directly impacted on cyclin D1 (show CCND1 Proteins) expression.
Data indicate that mitogen-activated protein kinase kinase 6 (MKK6) levels were substantially higher in monocytes than in neutrophils.
Data show significant increase in the expression of MKK6 in Esophageal, Stomach, and Colon cancers as compared to controls.
uncover a new mechanism of deactivation of MKK6-p38 (show CRK Proteins) and substantiate a novel regulatory role of FBXO31 (show FBXO5 Proteins) in stress response
Serine phosphorylation of p66shc (show SHC1 Proteins) is carried out by active MKK6. beta-Amyloid-induced ROS (show ROS1 Proteins) production and apoptosis increased in the presence of MKK6 and p66shc (show SHC1 Proteins), which directly associate.
The models confirmed the reaction order, revealed processivity in the phosphorylation of MEK6 by ASK1 (show MAP3K5 Proteins), and suggested that the order of phosphorylation is dictated by both binding and catalysis rates.
crystal structure of human non-phosphorylated MAP2K6 (npMAP2K6) complexed with an ATP analogue was determined at 2.6 A resolution and represents an auto-inhibition state of MAP2K6
Data suggest aberrant MAP2K protein (MKK3 (show MAP2K3 Proteins), MKK4 (show MAP2K4 Proteins), MKK6, and MKK7 (show MAP2K7 Proteins)) expression indicates that altered cellular signal transduction mediated via JNK (show MAPK8 Proteins) and p38 (show CRK Proteins) may be common in bladder cancer.
the balance between MKK6 and MKK3 (show MAP2K3 Proteins) mediates p38 MAPK (show MAPK14 Proteins) associated resistance to cisplatin in NSCLC
MAP2K6 functions in mouse testis determination, via positive effects on Sry (show SRY Proteins), and a minor role for MAP2K3 (show MAP2K3 Proteins).
MKK3 (show MAP2K3 Proteins) and MKK6 differentially regulate bone loss due to estrogen withdrawal. MKK3 (show MAP2K3 Proteins) directly mediates osteoclastogenesis while MKK6 likely contributes to pro-inflammatory cytokine production that promotes osteoclast formation.
Activation of distinct p38MAPK (show MAPK14 Proteins) isoforms is regulated by the selective and synchronized action of two kinases, MKK3 (show MAP2K3 Proteins) and MKK6, in response to cell stress.
MKK6 is downreglated in peripheral CD4 (show CD4 Proteins)(+)T cells
p38alpha (show MAPK14 Proteins) can negatively regulate the stability of the MKK6 mRNA and thus control the steady-state concentration of one of its upstream activators
Involvement of MKK6 in apoptotic cell death in thymocytes.
MKK6 is one of three different protein kinases which activate p38 MAPK (show MAPK14 Proteins) in vitro.
MKK3 (show MAP2K3 Proteins) and MKK6 are rapidly activated during engagement of the Type I IFN receptor and play important roles in Type I IFN signaling and the generation of IFN responses
increased activity of Sox9 (show SOX9 Proteins) accounts at least in part for the phenotype caused by constitutive activation of MKK6 in chondrocytes
Arabidopsis MPK4 (show MAPK4 Proteins) can interact with and be phosphorylated by the cytokinesis-related MAP kinase (show MAPK1 Proteins) kinase, AtMKK6.
AtMKK6-AtMPK13 module positively regulates lateral root formation.
Plants with mutations in the MKK6/ANQ gene exhibit severe defects in cytokinesis.
This gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis.
MAPK/ERK kinase 6
, MAPKK 6
, MEK 6
, SAPK kinase 3
, dual specificity mitogen-activated protein kinase kinase 6
, protein kinase, mitogen-activated, kinase 6 (MAP kinase kinase 6)
, stress-activated protein kinase kinase 3
, MAP kinase kinase 6
, mitogen activated protein kinase kinase 6
, protein kinase, mitogen activated, kinase 6
, mitogen-activated protein kinase kinase 3