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the p.Glu116Lys rare variant in MAP2K7 predisposes its carriers to develop COPD (show ARCN1 Proteins), which would provide a useful genetic biomarker for COPD (show ARCN1 Proteins) susceptibility in Chinese.
Combination BRAF (show BRAF Proteins) and MEK (show MAP2K1 Proteins) inhibition has also been shown to improve overall survival in patients with V600E-mutated melanoma. Responses to therapy are often rapid, and treatment is not associated with immune-related adverse events.
Our findings indicate that GADD45 (show GADD45A Proteins) essentially suppresses the MKK7-JNK (show MAPK8 Proteins) pathway and suggest that differentially expressed GADD45 (show GADD45A Proteins) family members fine-tune stress-inducible JNK (show MAPK8 Proteins) activity.
The latter insight is likely to promote the production of allosteric MAP2K7 inhibitors.
MEK activation cooperates with Cdkn2a and Pten inactivation to induce melanoma
MKK7 undergoes neddylation in human breast cancer cells
In an Eastern Chinese population, carriers of MAP2K7 rs3679T variant genotypes had an increased risk of NSCLC.
Therefore, EGF (show EGF Proteins) is suggested to induce E-cadherin (show CDH1 Proteins) down-regulation at the transcriptional level through the MEK (show MAP2K1 Proteins)/ERK (show EPHB2 Proteins) pathway, which might result in, at least in part, the induction of cellular morphological changes and cell migration in LoVo cells.
combined pan-RAF and MEK inhibition can overcome intrinsic and acquired resistance to single-agent RAF/MEK inhibition, supporting dual pan-RAF and MEK inhibition as a novel therapeutic strategy for BRAF- and KRAS-mutant cancers
our study suggested that black rice anthocyanins extract suppress metastasis in breast cancer cells by targeting the RAS/RAF (show RAF1 Proteins)/MAPK (show MAPK1 Proteins) pathway
High Map2k7 expression is associated with T-cell acute lymphoblastic leukemia.
The loss of mkk4 (show MAP2K4 Proteins) and mkk7 locks damaged exocrine cells in a permanently de-differentiated state.
Arrestin-3 (show ARRB2 Proteins) directly interacts with MKK7 and promotes JNK3alpha2 phosphorylation by both MKK4 (show MAP2K4 Proteins) and MKK7 in vitro as well as in intact cells.
MKK7 is specifically phosphorylated in the neurite shaft which triggers Map1b (show MAP1B Proteins) phosphorylation to regulate microtubule bundling leading to neurite elongation.
Data indicate that mitogen activated protein kinase kinase 7 (MKK7) plays a critical regulatory role in the c-Jun N-terminal kinase pathway in a murine model of rheumatoid arthritis.
a novel function for the stress kinase MKK7 as a regulator of the circadian clock in mammalian cells at steady state.
Distinct signaling properties of mitogen-activated protein kinase kinases 4 (MKK4) and 7 (MKK7) in embryonic stem cell (ESC) differentiation.
MKK4 (show MAP2K4 Proteins)/7 and JNK1 (show MAPK8 Proteins)/2 played regulatory role in cytoskeleton reorganization during vaccinia virus infection.
This study demonistrated that Stress-activated protein kinase (show CDK7 Proteins) MKK7 regulates axon elongation in the developing cerebral cortex.
The results reveal an essential role of MKK7 in cardiomyocytes for protecting the heart from hypertrophic insults thereby preventing the transition to heart failure.
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found, but only one transcript variant has been supported and defined.
mitogen-activated protein kinase kinase 7
, JNK kinase 2
, JNK-activating kinase 2
, JNKK 2
, MAP kinase kinase 7
, MAPK/ERK kinase 7
, MAPKK 7
, MEK 7
, c-Jun N-terminal kinase kinase 2
, dual specificity mitogen-activated protein kinase kinase 7
, SAPK kinase 4
, stress-activated protein kinase kinase 4
, mitogen activated protein kinase kinase 7
, protein kinase, mitogen activated, kinase 7