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|Antigen||Mitogen-Activated Protein Kinase 7 (MAPK7) Antibodies|
|Conjugate||This MAPK7 antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
|2 references available|
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Product Details anti-MAPK7 AntibodyTarget Details MAPK7 Application Details Handling References for anti-MAPK7 antibody (ABIN359634) Images
|Specificity||This antibody reacts to ERK5.|
|Purification||Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS|
|Immunogen||This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human ERK5.|
Target Details MAPK7Product Details anti-MAPK7 Antibody Application Details Handling References for anti-MAPK7 antibody (ABIN359634) Images back to top
|Alternative Name||MAPK7 / ERK5 (MAPK7 Antibody Abstract)|
|Background||MEK5 and ERK5, a member of the MAP kinase subfamily of the Ser/Thr protein kinases, interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. ERK5 is activated by tyrosine and threonine phosphorylation It is expressed in many adult tissues, abundantly in heart, placenta, lung, kidney and skeletal muscle, but is not detectable in liver. The second proline-rich region may interact with actin targeting the kinase to a specific location in the cell. ERK5 is autophosphorylated on threonine and tyrosine residues when the C-terminal part of the kinase, which could have a regulatory role, is absent.Synonyms: Big MAP kinase 1, ERK4, Extracellular signal-regulated kinase 5, MAPK7, Mitogen-activated protein kinase 7|
|Gene ID||5598, 9606|
|Pathways||MAPK Signaling, Neurotrophin Signaling Pathway, Activation of Innate immune Response, cAMP Metabolic Process, Toll-Like Receptors Cascades, Negative Regulation of intrinsic apoptotic Signaling|
Application DetailsProduct Details anti-MAPK7 Antibody Target Details MAPK7 Handling References for anti-MAPK7 antibody (ABIN359634) Images back to top
ELISA: 1/1,000. Western blotting: 1/100 - 1/500. Immunohistochemistry: 1/50 - 1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-MAPK7 Antibody Target Details MAPK7 Application Details References for anti-MAPK7 antibody (ABIN359634) Images back to top
|Buffer||PBS with 0.09 % (W/V) sodium azide|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.|
References for anti-MAPK7 antibody (ABIN359634)Product Details anti-MAPK7 Antibody Target Details MAPK7 Application Details Handling Images back to top
Zhou, Bao, Dixon: "Components of a new human protein kinase signal transduction pathway." in: The Journal of biological chemistry, Vol. 270, Issue 21, pp. 12665-9, 1995
Lee, Ulevitch, Han: "Primary structure of BMK1: a new mammalian map kinase." in: Biochemical and biophysical research communications, Vol. 213, Issue 2, pp. 715-24, 1995
ImagesProduct Details anti-MAPK7 Antibody Target Details MAPK7 Application Details Handling References for anti-MAPK7 antibody (ABIN359634) back to top