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|Antigen||Microtubule-Associated Protein tau (MAPT) Antibodies|
|Reactivity||Cow (Bovine), Human Alternatives|
|Conjugate||This MAPT antibody is un-conjugated Alternatives|
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
|7 references available|
|Supplier||Log in to see|
Product Details anti-MAPT AntibodyTarget Details MAPT Application Details Handling References for anti-MAPT antibody (ABIN3043669) Images
|Purpose||Mouse IgG monoclonal antibody for Tau, microtubule-associated protein tau (MAPT) detection. Tested with WB, IHC-P in Human,bovine. No cross reactivity with other proteins.|
|Cross-Reactivity (Details)||No cross reactivity with other proteins.|
Mouse IgG monoclonal antibody for Tau, microtubule-associated protein tau (MAPT) detection. Tested with WB, IHC-P in Human,bovine.
Gene Name: microtubule-associated protein tau
Protein Name: Microtubule-associated protein tau
|Immunogen||Bovine microtubule-associated proteins(MAPs).|
|Plasmids, Primers & others|
Target Details MAPTProduct Details anti-MAPT Antibody Application Details Handling References for anti-MAPT antibody (ABIN3043669) Images back to top
|Alternative Name||MAPT (MAPT Antibody Abstract)|
The microtubule-associated proteins(MAPs) coassemble with tubulin into microtubules in vitro. Microtubule-associated protein tau appears to be enriched in axons. Tau are composed of 352 to 441 amino acids. The isoforms differ from each other by the presence or absence of 29-amino acid or 58-amino acid inserts located in the N terminus and a 31-amino repeat located in the C terminus. tau is important in establishing and maintaining neuronal morphology and is a major component of the neurofibrillary tangles(NFTs) characteristic of Alzheimer's brain. Microtubule-associated protein tau(MTBT1) is mapped to chromosome 17q21.
Synonyms: DDPAC|MAPTL|PHF-tau|FLJ31424|FTDP-17|MGC138549|MSTD|MTBT1|MTBT2|PPND|TAU|G protein beta1/gamma2 subunit-interacting factor 1|microtubule-associated protein tau, isoform 4|Neurofibrillary tangle protein|Paired helical filament-tau
|Gene ID||4137, 17762, 29477|
|UniProt||P10636, P10637, P19332|
|Pathways||MAPK Signaling, Microtubule Dynamics, M Phase, Regulation of Cell Size|
Application DetailsProduct Details anti-MAPT Antibody Target Details MAPT Handling References for anti-MAPT antibody (ABIN3043669) Images back to top
WB: Concentration: 0.5-1 μg/mL, Species: Human, bovine
IHC-P: Concentration: 1-2 μg/mL, Species: Human, bovine
Notes: Other applications have not been tested. Optimal dilutions should be determined by end users.
Antibody can be supported by chemiluminescence kit ABIN921123 in WB, supported by ABIN921230 in IHC(P).
|Restrictions||For Research Use only|
HandlingProduct Details anti-MAPT Antibody Target Details MAPT Application Details References for anti-MAPT antibody (ABIN3043669) Images back to top
|Reconstitution||Add 1 mL of PBS buffer will yield a concentration of 100 μg/mL.|
|Buffer||Mouse ascites fluid, 1.2 % sodium acetate, 2 mg BSA, with 0.01 mg Sodium azide as preservative.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
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|Product cited in:||
Tang, Yu, Wu, Chen, Zeng, Wang, Yang, Mei, Cao, Qin: "Lychee seed extract protects against neuronal injury and improves cognitive function in rats with type II diabetes mellitus with cognitive impairment." in: International journal of molecular medicine, Vol. 41, Issue 1, pp. 251-263, 2018
Zhou, Liu, Yuan, Lu: "The expression of insulin-like growth factor-1 in senior patients with diabetes and dementia." in: Experimental and therapeutic medicine, Vol. 13, Issue 1, pp. 103-106, 2017
Zhu, Li, Yuan, Li, Tian, Jia, Xiao: "Allicin improves endoplasmic reticulum stress-related cognitive deficits via PERK/Nrf2 antioxidative signaling pathway." in: European journal of pharmacology, Vol. 762, pp. 239-46, 2015
Li, Li, Li, Quan, Wang: "Cellular and molecular mechanisms underlying the action of ginsenoside Rg1 against Alzheimer's disease." in: Neural regeneration research, Vol. 7, Issue 36, pp. 2860-6, 2014
Tu, Pang, Chen, Zhang, Zhang, Lu, Wang: "Effects of surface charges of graphene oxide on neuronal outgrowth and branching." in: The Analyst, Vol. 139, Issue 1, pp. 105-15, 2013
Wang, Feng, Fu, Li: "Panax notoginsenoside Rb1 ameliorates Alzheimer's disease by upregulating brain-derived neurotrophic factor and downregulating Tau protein expression." in: Experimental and therapeutic medicine, Vol. 6, Issue 3, pp. 826-830, 2013
Tan, Cao, Wang, Lv, Wu, Ma: "Protective effects of lithium treatment for spatial memory deficits induced by tau hyperphosphorylation in splenectomized rats." in: Clinical and experimental pharmacology & physiology, Vol. 37, Issue 10, pp. 1010-5, 2010
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