Browse our anti-PAK2 (PAK2) Antibodies

Full name:: anti-P21-Activated Kinase 2 Antibodies (PAK2)

On www.antibodies-online.com are 205 P21-Activated Kinase 2 (PAK2) Antibodies from 30 different suppliers available. Additionally we are shipping PAK2 Proteins (15) and PAK2 Kits (11) and many more products for this protein. A total of 249 PAK2 products are currently listed.

Synonyms:: 5330420P17Rik, A130002K10Rik, AI836325, cb422, D16Ertd269e, gamma-PAK, kinase, mKIAA4182, PAK-2, pak2, Pak3, pak65, pakgamma, PAKI, si:dz198m22.1, wu:fb71h01, zgc:91798

list all antibodies	Gene Name	GeneID	UniProt
	PAK2	5062	Q13177
	PAK2	29432	Q64303
	PAK2	224105	Q8CIN4
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Most Popular Reactivities for anti-PAK2 (PAK2) Antibodies

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anti-Human PAK2 Antibodies:

anti-Rat (Rattus) PAK2 Antibodies:

anti-Mouse (Murine) PAK2 Antibodies:

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Relevant Pathways for anti-PAK2 Antibodies

Regulation of Lipid Metabolism by PPARalpha

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Top referenced anti-PAK2 Antibodies

Human Monoclonal PAK2 Primary Antibody for ICC, IHC - ABIN969338 : Chu, Wu, Liao, Pardo, Zhao, Li, Mendenhall, Pali, Shen, Yu, Taylor, Aversa, Molineaux, Payan, Masuda: A novel role for p21-activated protein kinase 2 in T cell activation. in Journal of immunology (Baltimore, Md. : 1950) 2004 (PubMed)
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Human Polyclonal PAK2 Primary Antibody for IHC (p), WB - ABIN2476049 : Rudel, Bokoch: Membrane and morphological changes in apoptotic cells regulated by caspase-mediated activation of PAK2. in Science (New York, N.Y.) 1997 (PubMed)
Show all 3 Pubmed References
Human Polyclonal PAK2 Primary Antibody for IHC, ELISA - ABIN1002956 : Jaffer, Chernoff: p21-activated kinases: three more join the Pak. in The international journal of biochemistry & cell biology 2002 (PubMed)
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Human Polyclonal PAK2 Primary Antibody for IHC, ELISA - ABIN1002955 : Vilas, Corvi, Plummer, Seime, Lambkin, Berthiaume: Posttranslational myristoylation of caspase-activated p21-activated protein kinase 2 (PAK2) potentiates late apoptotic events. in Proceedings of the National Academy of Sciences of the United States of America 2006 (PubMed)
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Human Polyclonal PAK2 Primary Antibody for IP, WB - ABIN253074 : Qu, Misaghi, Izrael-Tomasevic, Newton, Gilmour, Lamkanfi, Louie, Kayagaki, Liu, Kömüves, Cupp, Arnott, Monack, Dixit: Phosphorylation of NLRC4 is critical for inflammasome activation. in Nature 2012 (PubMed)

More Antibodies against PAK2 Interaction Partners

Human P21-Activated Kinase 2 (PAK2) interaction partners

Overexpression of PAK2 in oral squamous cell carcinomas may be associated with an advanced pathology grade.
the promotion of apoptosis by human cytomegalovirusmiRUS45p in cells was specifically mediated via inhibition of PAK2 expression.
leukaemic cells explicitly require PAK2 to grow towards an extracellular matrix. PAK2-deficient cells fail to form colonies in methylcellulose and to induce lymphomas in vivo. PAK2 might therefore be the critical isoform in leukaemic cells by controlling tumour growth
Results show that PAK2 kinase plays an alternative anti-apoptotic role, phosphorylating caspase-7 (show CASP7 Antibodies) and promoting unfettered cell growth and chemotherapeutic resistance.
We found that overexpression of miR (show MLXIP Antibodies)-137 inhibited the proliferation of melanoma cells, which could be phenocopied by knockdown of PAK2 using siRNAs.
PAK2 is a direct effector of TSC1 (show TSC1 Antibodies)-TSC2 (show TSC2 Antibodies)-RHEB (show RHEB Antibodies) signaling and a new target for rational drug therapy in TSC (show SLC12A3 Antibodies).
Nef exploits PAK2 in a stepwise mechanism in which its kinase activity cooperates with an adaptor function for the exocyst complex to inhibit host cell actin dynamics.
Cytoplasmic Pak2 may promote cell proliferation in normal endometrium during menstrual cycle.
Further analyses show that HDAC6 (show HDAC6 Antibodies) may promote growth of GBM cells through inhibition of SMAD2 (show SMAD2 Antibodies) phosphorylation to downregulate p21 (show CDKN1A Antibodies)
Pak1 (show PAK1 Antibodies) and Pak2 counteract centrosome separation in a kinase-dependent manner.

Mouse (Murine) P21-Activated Kinase 2 (PAK2) interaction partners

PAK2 acts as a Rac1 (show RAC1 Antibodies)-dependent negative regulator of neuronal glucose uptake and insulin (show INS Antibodies) sensitivity.
These results identify Pak1 (show PAK1 Antibodies) and Pak2 as redundant regulators of myoblast differentiation in vitro and in vivo and as components of the promyogenic Ncad (show CDH2 Antibodies)/Cdo (show CDO1 Antibodies)/Cdc42 (show CDC42 Antibodies) signaling pathway.
PAK-mediated phosphorylation of PKD1 at Ser203 triggers its membrane dissociation and subsequent entry into the nucleus, thereby regulating the phosphorylation of PKD1 nuclear targets, including class IIa histone deacetylases.
Data indicate that resveratrol treatment inhibits neuronal glucose uptake via P21-activated kinase 2 (PAK2).
Mechanistic insights into the role of Pak2 in hematopoietic stem cells migration and homing.
Pak2 disruption decreased the survival and proliferation of multicytokine stimulated immature progenitors.
The data suggest that Pak2 controls thymic Natural Killer T-cell development by providing a signal that links Egr2 (show EGR2 Antibodies) to induce PLZF (show ZBTB16 Antibodies), in part by regulating signaling lymphocyte activation molecule (show SLAMF1 Antibodies) 6 expression.
In adult endothelial cells, Pak2 depletion leads to severe apoptosis and acute angiogenesis defects, and in adult mice, endothelial Pak2 deletion leads to increased vascular permeability.
Pak2 Links TCR Signaling Strength to the Development of Regulatory T Cells and Maintains Peripheral Tolerance
Failure to induce proper actin cytoskeletal remodeling impaired PLCgamma1 and Erk1/2 signaling in the absence of Pak2, uncovering the critical function of Pak2 as an essential regulator that governs the actin cytoskeleton-dependent signaling

Zebrafish P21-Activated Kinase 2 (PAK2) interaction partners

EphrinB ligands B2a and B3b, the Ephb4a (show EPHB4 Antibodies) receptor and the Pak2a kinase are required for the development of pharyngeal pouches and the segmentation of the posterior facial skeleton.
Essential in vivo role for betaPix (show ARHGEF7 Antibodies) and Pak2a during embryonic development and a previously unrecognized pathway specifically involved in cerebrovascular stabilization. [BetaPix (show ARHGEF7 Antibodies) AND Pak2a]
Data provide evidence for a critical function of Pak2 in vascular integrity and demonstrate a severe disease phenotype resulting from loss of Pak2 function.

Cow (Bovine) P21-Activated Kinase 2 (PAK2) interaction partners

Basement membrane proteins promote PAK2 Ser (show SIGLEC1 Antibodies)-20 phosphorylation through enhanced eNOS (show NOS3 Antibodies) activation and NO production.

PAK2 Antigen Profile

Antigen Summary

The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell.

Alternative names and synonyms associated with PAK2

p21 (RAC1) activated kinase 2 (PAK2) antibody
p21 protein (Cdc42/Rac)-activated kinase 2 (Pak2) antibody
p21 protein (Cdc42/Rac)-activated kinase 2a (pak2a) antibody
p21 protein (Cdc42/Rac)-activated kinase 2 S homeolog (pak2.S) antibody
p21 (RAC1) activated kinase 2 (Pak2) antibody

5330420P17Rik antibody
A130002K10Rik antibody
AI836325 antibody
cb422 antibody
D16Ertd269e antibody
gamma-PAK antibody
kinase antibody
mKIAA4182 antibody
PAK-2 antibody
pak2 antibody
Pak3 antibody
pak65 antibody
pakgamma antibody
PAKI antibody
si:dz198m22.1 antibody
wu:fb71h01 antibody
zgc:91798 antibody

Protein level used designations for PAK2

PAK-2 , S6/H4 kinase , gamma-PAK , p21 (CDKN1A)-activated kinase 2 , p21-activated kinase 2 , p58 , serine/threonine-protein kinase PAK 2 , redhead , rhd , p21 activated kinase 2 , p21-activated kinase I , p21-activated protein kinase I

GENE ID	SPECIES
5062	Homo sapiens
29432	Rattus norvegicus
224105	Mus musculus
266749	Danio rerio
399090	Xenopus laevis
460965	Pan troglodytes
100009535	Oryctolagus cuniculus
513673	Bos taurus
424860	Gallus gallus
612814	Canis lupus familiaris
100713135	Cavia porcellus

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