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|Antigen||P21-Activated Kinase 2 (PAK2) Antibodies|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This PAK2 antibody is un-conjugated Alternatives|
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
|Supplier||Log in to see|
Product Details anti-PAK2 AntibodyTarget Details PAK2 Application Details Handling Images
|Purification||Purified by Protein A.|
|Immunogen||KLH conjugated synthetic phosphopeptide derived from human PAK2 around the phosphorylation site of Ser20|
Target Details PAK2Product Details anti-PAK2 Antibody Application Details Handling Images back to top
|Alternative Name||Pak2 (PAK2 Antibody Abstract)|
The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell.P21-activated kinase (PAK) is actually a family of serine/threonine protein kinases, members of which are activated by small molecular weight GTPases. The three most common isoforms are PAK 1, PAK 2, and PAK 3 (also known as alpha PAK, gamma PAK, and beta PAK, respectively). These kinases contain numerous regulatory elements that trigger diverse signaling processes such as those initiated by activated GTPases, interaction with Src homology 3 (SH3) domains, and caspase mediated proteolytic cleavage. Autophosphorylation of serine 141 (serine 144 for PAK 1 and serine 139 PAK 3), catalyzed by Cdc42, is required for activation of PAK.
Synonyms: PAK2 phospho S20, PAK2 phospho Ser20, p-PAK2 S20, p-PAK2 Ser20, CB422, EC 22.214.171.124, Gamma PAK, hPAK65, Kinase, p21 CDKN1A-activated kinase 2a, p21 activated kinase 2, p21 protein Cdc42/Rac-activated kinase 2, p21 protein Cdc42 Rac activated kinase 2, p21-activated kinase, 65-KD antibody p21-activated protein kinase I, p21CDKN1A activated kinase 2, p58, p65PAK, PAK 2, PAK65, PAKgamma, S6 H4 kinase, Serine threonine protein kinase PAK 2.
|Research Area||Cancer, Apoptosis/Necrosis, Tyrosine Kinases, Kinases/Phosphatases|
|Pathways||MAPK Signaling, RTK Signaling, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, Regulation of Lipid Metabolism by PPARalpha|
Application DetailsProduct Details anti-PAK2 Antibody Target Details PAK2 Handling Images back to top
|Restrictions||For Research Use only|
HandlingProduct Details anti-PAK2 Antibody Target Details PAK2 Application Details Images back to top
|Buffer||Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.|
|Storage Comment||Store at -20°C|
|Expiry Date||12 months|