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|Antigen||P21-Activated Kinase 2 (PAK2) Antibodies|
|Reactivity||Human, Mouse (Murine), Rabbit, Rat (Rattus) Alternatives|
|Conjugate||This PAK2 antibody is un-conjugated Alternatives|
Western Blotting (WB)
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Product Details anti-PAK2 AntibodyTarget Details PAK2 Application Details Handling Images
|Blocking Peptide||Blocking peptide for this product available: ABIN412863|
The antibody recognizes 60 kDa Pak2 of human, mouse, rat, and rabbit origins.
The antibody does not cross-react with Pak1, Pak3, and Pak4-6.
Reactivity to other species has not been tested.
|Cross-Reactivity (Details)||Does not cross-react with Pak1, Pak3, and Pak4-6.|
|Immunogen||Synthetic peptide corresponding to residues surrounding amino acid 5 of human Pak2|
Target Details PAK2Product Details anti-PAK2 Antibody Application Details Handling Images back to top
|Alternative Name||PAK2 (PAK2 Antibody Abstract)|
The PAK (p21-activated kinase) family of serine/threonine kinases plays an important role in multiple cellular processes, including cytoskeletal reorganization, MAPK signaling, apoptotic signaling, etc. Binding of Rac/cdc42 to the CRIB (or PBD) domain at the N-terminal region of PAK causes autophosphorylation and conformational change of PAK. Phosphorylation of Ser21 of PAK1 or Ser20 of PAK2 regulates its binding with the adaptor protein Nck.
Synonyms: PAK-2 , PAK65 , Gamma-PAK , hPAK65 , PAKgamma
|Research Area||Cancer, Apoptosis/Necrosis, Tyrosine Kinases, Kinases/Phosphatases|
|Pathways||MAPK Signaling, RTK Signaling, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, Regulation of Lipid Metabolism by PPARalpha|
Application DetailsProduct Details anti-PAK2 Antibody Target Details PAK2 Handling Images back to top
|Application Notes||Western blotting (0.5-4 μg/mL). However, the optimal concentrations should be determined individually. Jurkat cell lysate can be used as a positive control. The antibody recognizes 60 kDa Pak2 of human, mouse, rat, and rabbit origins. The antibody does not cross-react with Pak1, Pak3, and Pak4-6. Reactivity to other species has not been tested.|
|Restrictions||For Research Use only|
HandlingProduct Details anti-PAK2 Antibody Target Details PAK2 Application Details Images back to top
|Buffer||100 μg (0.5 mg/mL) affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30 % glycerol, 0.5 % BSA, and 0.01 % thimerosal.|
|Precaution of Use||This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||The antibody solution should be gently mixed before use.|
|Storage Comment||For long-term storage, aliquot and freeze at -70 °C.|
|Expiry Date||12 months|
ImagesProduct Details anti-PAK2 Antibody Target Details PAK2 Application Details Handling back to top