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Pin1 (show PIN1 Proteins) enhances adipocyte differentiation by regulating the function of PPARgamma.
The authors report that macrophage PPARgamma deletion in mice not only exacerbates mammary tumor development but also impairs the anti-tumor effects of rosiglitazone. Mechanistically, the authors identify Gpr132 (show GPR132 Proteins) as a novel direct PPARgamma target in macrophage whose expression is enhanced by PPARgamma loss but repressed by PPARgamma activation.
Data indicate that obesity-induced insulin (show INS Proteins) resistance and lipotoxicity can be treated with ginsenoside Rg3, which acts though the STAT5 (show STAT5A Proteins)-PPAR gamma pathway in vivo and in vitro.
TAK1 (show NR2C2 Proteins) is required for PPARgamma transactivation and promotes PPARgamma transcriptional activity synergistically with TAK1 binding protein 1 (TAB1 (show TAB1 Proteins)).
PPAR gamma role in fat deposition and body weight gain.PPAR gamma is regulated by miR (show MLXIP Proteins)-27b.
These findings demonstrated that apigenin could prevent the D-GalN (show GAL Proteins)/LPS (show TLR4 Proteins)-induced liver injury in mice, and its mechanisms might be associated with the increments of Nrf-2 (show NFE2L2 Proteins)-mediated antioxidative enzymes and modulation of PPARgamma/NF-kappaB (show NFKB1 Proteins)-mediated inflammation.
Time course analysis demonstrated that the adipogenic 'hub', sampled by PPARgamma and Lpin1 (show LPIN1 Proteins), undergoes orchestrated reorganization during adipogenesis.
Aleglitazar protects cardiomyocytes against hyperglycaemia-induced apoptosis by combined activation of both peroxisome proliferator-activated receptor-alpha (show PPARA Proteins) and peroxisome proliferator-activated receptor-gamma.
IRF6 (show IRF6 Proteins) suppresses PPARgamma through binding IRF (show TRIM63 Proteins) recognition sites located upstream of the PPARgamma coding region. Taken together, the results suggest that an IRF6 (show IRF6 Proteins)/PPARgamma regulatory axis suppresses anti-inflammatory responses in bone marrow-derived macrophages and provides references for future study addressing dysregulated metabolic and immunologic homeostasis of obese adipose tissue.
NFIA (show NFIA Proteins) activates the cell-type-specific enhancers and facilitates the binding of PPARgamma to control the brown fat gene program.
Immune cell-infiltration is controlled by activated peroxisome proliferator activated receptor gamma (PPARgamma)/retinoid X receptor alpha (RXRalpha (show RXRA Proteins)) that inhibits expression/secretion of inflammatory cytokines.
Results show that resistin (show RETN Proteins) down-regulates the transcription of GLUT1 (show SLC2A1 Proteins) by suppressing the expression of PPARG, thus causing impaired glucose transportation in endothelial cell layers.
these studies demonstrate that PPARgamma is an important modulator of MUC16 (show MUC16 Proteins) expression.
a panel of proteins correlated with PPARgamma expression that could be associated with colorectal cancer, was identified.
We propose a novel role of the miR (show MLXIP Proteins)-27a/PPARgamma/beta-catenin (show CTNNB1 Proteins) axis in fostering the progression toward more deteriorated podocyte injury in diabetic nephropathy (DN). Targeting miR (show MLXIP Proteins)-27a could be a potential therapeutic approach for DN.
the presented cPCA mapping of the PPARg-ligand complexes may guide in silico drug discovery programs seeking to avoid stabilization of helix 12 in their development of partial- and non-agonistic PPARg ligands.
The presence of the PPARgamma (Pro12Ala) SNP did not modify the association between inorganic arsenic methylation capacity and breast cancer.
COX-2 is a potential marker for identifying high-risk sebaceous gland carcinoma (SGC (show SGCB Proteins)) patients. Expression of PPAR-gamma in eyelid SGC (show SGCB Proteins) cases reflects terminal sebaceous differentiation.
PAK4 (show PAK4 Proteins) downregulation decreased PPARgamma-mediated Nox1 (show NOX1 Proteins) expression and suppressed EMT (show ITK Proteins) in IR-treated glioma cells.
The results suggest the higher expression of miR (show MYLIP Proteins)-130a, which targeting peroxisome proliferator-activated receptor gamma, may be the reason for less fat deposition in intramuscular adipose tissue than subcutaneous adipose tissue.
The immunoprecipitation results also showed that high AA concentrations significantly increased the interaction of mTOR (show FRAP1 Proteins) and PPARg. In summary, PPARg plays an important role in the regulation of IGF-1 (show IGF1 Proteins) secretion and gene expression in response to dietary protein.
The regulatory role of microRNA miR (show MYLIP Proteins)-27b-3p on peroxisome proliferator-activated receptor-gamma (PPARgamma) was confirmed by their inversed expression patterns in oocytes: [miR (show MYLIP Proteins)-27b-3p]
an Enhancer box and a binding site for a cooperative co-activator of MyoD (show MYOD1 Proteins) are present in the promoter region of porcine PPARgamma.
The data suggest that there is local cooperation between resistin (show RETN Proteins) and PPARgamma expression in the porcine ovary. Resistin (show RETN Proteins) significantly increased the expression of PPARgamma, whereas PPARgamma decreased resistin (show RETN Proteins) expression; thus, PPARgamma is a new key regulator of resistin (show RETN Proteins) expression and function.
Therefore, this study demonstrated that the different regulatory adipogenic roles of MSTN (show MSTN Proteins) in ADSCs and MSCs act by differentially regulating PPARgamma and MyoD (show MYOD1 Proteins) expression.
PGRN (show GRN Proteins) inhibits adipogenesis in porcine preadipocytes partially through ERK (show MAPK1 Proteins) activation mediated PPARgamma phosphorylation.
Resveratrol activated sirtuin 1 (Sirt1 (show SIRT1 Proteins)) gene expression and increased adipose triglyceride lipase (ATGL (show PNPLA2 Proteins)) gene expression and glycerol release. Furthermore, this study found the opposite Sirt1 (show SIRT1 Proteins) regulation pattern for PPARgamma to that of ATGL (show PNPLA2 Proteins) in adipocytes.
The results indicate that the endometrial expression of PPARgamma genes fluctuates during the estrous cycle and pregnancy.
Increasing dietary DE linearly enhanced the expression of PPARgamma in adipose tissues but not skeletal muscle of Rongchang piglets.
These results indicated that docosahexaenoic acid may attenuate lipopolysaccharide-stimulated inflammatory response in bovine mammary epithelial cells by suppressing NF-kappaB (show NFKB1 Proteins) activation through a mechanism partly dependent on PPARgamma activation.
PPARgamma is a positive regulator of milk fat synthesis in dairy cow mammary epithelial cells.
An Asp7Gly substitution in PPARG is associated with adiposity.
upregulation of PPARgamma was observed in the backfat tissue of Lilu cattle with increasing age
Co-culture of adipocytes and myoblasts elicited an increase in C/EBPbeta (show CEBPB Proteins) and PPAR-gamma gene expression in differentiated myoblasts and an increase in GPR43 (show FFAR2 Proteins) gene expression in adipocytes.
A potential association of an single nucleotide polymorphism (72472 GT in exon7) of the bovine PPAR-gamma gene with carcass and meat quality traits, was evaluated.
study demonstrates the co-expression of DLX3 (show DLX3 Proteins), PPARG and SP1 (show SP1 Proteins) in trophoblast binucleated cell(BNC)nuclei; this suggests a possible role of these transcription factors through BNC specific genes at the time of pre-placental differentiation
Single nucleotide polymorphisms in coding region of the PPARgamma gene, were examined.
oxidative stress attenuates PPAR gamma expression and activity in vascular endothelial cells
The effects of dietary fat components on the expression of PPAR-gamma AND PPAR-gamma coactivator 1 in cultured bovine preadipocytes are reported.
study found PPAR-gamma expression was prominent in the subthalamic nucleus, oculomotor nucleus, ventral tegmental nucleus, and to a lesser extent, in the putamen; 3 or 12 months after MPTP (show PTPN2 Proteins), only the lesioned putamen had increased PPAR-gamma
Aleglitazar, a dual PPARalpha (show PPARA Proteins)/gamma agonist, has beneficial effects on both lipid and glucose parameters in a primate model of the metabolic syndrome.
siRNA targeting PPARgamma gene can inhibit adipogenic differentiation of BMSCs and prevent steroid-induced osteonecrosis in rabbit.
vitamin E supplementation affords protection by decreasing MMP-1 (show MMP1 Proteins) and increasing PPARg, GSTa (show GSTa2 Proteins), and ABCA1 (show ABCA1 Proteins) levels in aortae of rabbits fed a cholesterol-rich diet
Telmisartan improves microvascular dysfunction during myocardial ischemia/reperfusion injury via the PPARgamma pathway.
PPARgamma plays a luteotropic role in pseudopregnant rabbits, through PTGS2 (show PTGS2 Proteins) down-regulation and 3beta-HSD (show HAL Proteins) up-regulation, with a consequent PGF2alpha decrease and progesterone increase.
In an animal model of atherosclerosis, the expression of PPAR-gamma is upregulated following atorvastatin administration.
Tongxinluo can inhibit the expression of MMP-3 (show MMP3 Proteins) and 9 and increase the expression of PPARgamma in atherosclerotic rabbits.
Niacin Reduces serum level and adipose mRNA expression of leptin (show LEP Proteins) and up-regulates PPARgamma and CD36 (show CD36 Proteins) mRNA expression in hypercholesterolemic rabbits.
Antidiabetic drug pioglitazone protects the heart via activation of PPAR-gamma receptors, PI3-kinase (show PIK3CA Proteins), Akt (show AKT1 Proteins), and eNOS (show NOS3 Proteins) pathway in a rabbit model of myocardial infarction.
This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described.
peroxisome proliferator activated receptor gamma
, peroxisome proliferative activated receptor gamma
, peroxisome proliferator-activated receptor gamma
, peroxisome proliferator activator receptor gamma
, nuclear receptor subfamily 1 group C member 3
, peroxisome proliferator activated receptor gamma 2
, peroxisome proliferator activated receptor gamma 4
, Nuclear receptor subfamily 1 group C member 3
, PPAR gamma
, peroxisome proliferator-activated nuclear receptor gamma variant 1
, peroxisome proliferator-activated receptor gamma 1
, peroxisome proliferator activator receptor, gamma
, PPAR gamma 2
, xPPAR gamma
, peroxisome proliferative activated receptor, gamma
, peroxisome proliferator-activated receptor gamma 2
, peroxisome proliferator-activated receptor gamma 1-a
, peroxisome proliferator-activated receptor gamma 1-b
, PPAR gamma 1
, peroxisome proliferator activated receptor gamma-1
, peroxisome proliferator-activated receptor-gamma