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the extracts dramatically attenuated the levels of adipogenic transcriptional factors, including CCAAT enhancer-binding protein alpha (C/EBPa (show CEBPA Proteins)), CCAAT enhancer-binding protein beta (C/EBPb (show CEBPB Proteins)), and gamma receptors by peroxisome proliferators (PPARg), during adipogenesis
these findings identified an important role of renal tubular epithelium-targeted PPAR-gamma in maintaining the normal epithelial phenotype and opposing fibrogenesis, possibly via antagonizing oxidative stress
Activation of PPARgamma in hematopoietic stem cells impaired hematopoietic repopulation. PPARgamma inhibition by shRNA or chemical compounds significantly improves the repopulating ability of Fancd2-/- HSCs.
Study found that the metabolic master regulator PGC-1alpha is differentially affected by ALS-associated mutations in brain vs. peripheral tissues. Increased PGC-1alpha activity in peripheral tissue contributes to the metabolic phenotype, while in the CNS blunting of the PGC-1alpha response renders motoneurons vulnerable.
DBZ is a putative PPARgamma agonist that prevents HFD-induced obesity-related metabolic syndrome and reverse gut (show GUSB Proteins) dysbiosis. DBZ may be used as a beneficial probiotic agent to improve HFD-induced obesity-related metabolic syndrome in obese individuals
Altogether, the authors demonstrate that Dnmt3a (show DNMT3A Proteins) and Dnmt3b (show DNMT3B Proteins) protect the epidermis from tumorigenesis and that squamous carcinomas are sensitive to inhibition of PPAR-gamma.
FBXO9 (show FBXO9 Proteins) directly interacted with PPAR gamma through the activation function-1 domain and ligand-binding domain. FBXO9 (show FBXO9 Proteins) decreased the protein stability of PPAR gamma through induction of ubiquitination.
inhibition of Hsp90 (show HSP90 Proteins) in Sec61a1 (show SEC61A1 Proteins) mutant hepatocytes also reduced Ppargamma protein levels and signaling.
Identification of a PPAR-gamma --> NF-kappaB (show NFKB1 Proteins) --> p22phox (show CYBA Proteins) neuroprotective signaling cascade opens a new avenue for protecting the brain against ischemic insult.
TET proteins, particularly TET2, were required for adipogenesis by modulating DNA methylation (show HELLS Proteins) at the Ppargamma locus, subsequently by inducing Ppargamma gene expression.
UCP2 (show UCP2 Proteins) is a key mediator of hypoxia-triggered chemoresistance in non-small cell lung cancer cells via repression of peroxisome proliferator-activated receptor gamma.
MERS-CoV S protein (show CDSN Proteins) binds to DPP4 (show DPP4 Proteins) to suppress macrophage activation via induction of IRAK-M (show IRAK3 Proteins), PPARgamma and the immunosuppressive cytokine IL-10 (show IL10 Proteins).
our findings provide novel insights into the role of PPARgamma in inhibiting breast cancer progression
Results demonstrate that phosphorylation of PPARgamma at Ser84 is up-regulated in hepatocellular carcinoma (HCC (show FAM126A Proteins)) tumors. The study provides the first evidence that the novel roles of PPARgamma are linked to glycolysis by PFKFB4 (show PFKFB4 Proteins) for the regulation of glycolysis and proliferation in HCC (show FAM126A Proteins) cells.
These results indicated that AKT (show AKT1 Proteins)-PPARgamma signaling pathway mediated HG-induced lipid deposition by upregulating CD36 (show CD36 Proteins) expression in HK-2 (show HK2 Proteins) cells and that inhibition of AKT (show AKT1 Proteins)-PPARgamma signaling pathway had the potential beneficial effects of reducing lipid deposition in diabetic kidney.
Consumption of a high-fat, high-calorie meal is associated with an increase in intracellular co-localization of PPARgamma mRNA and protein in monocytes.
it was demonstrated that the risk of one of the diabetic complications, i.e., diabetic nephropathy, was associated with the variable rs1801282 locus of the PPARG2 gene.
PPARgamma gene polymorphism was associated with serum hsCRP level and periodontitis as BMI increased in post-menopausal Japanese women.
Treatment with peroxisome proliferator activated receptor gamma (PPARgamma) ligands significantly alters organic cation transporter-1 (OCT-1) activity in BCR (show BCR Proteins)-ABL1 (show ABL1 Proteins)+ chronic myeloid leukemia (show BCL11A Proteins) (CML (show BCR Proteins)) cell lines.
The results suggest the higher expression of miR (show MYLIP Proteins)-130a, which targeting peroxisome proliferator-activated receptor gamma, may be the reason for less fat deposition in intramuscular adipose tissue than subcutaneous adipose tissue.
The immunoprecipitation results also showed that high AA concentrations significantly increased the interaction of mTOR (show FRAP1 Proteins) and PPARg. In summary, PPARg plays an important role in the regulation of IGF-1 (show IGF1 Proteins) secretion and gene expression in response to dietary protein.
The regulatory role of microRNA miR (show MYLIP Proteins)-27b-3p on peroxisome proliferator-activated receptor-gamma (PPARgamma) was confirmed by their inversed expression patterns in oocytes: [miR (show MYLIP Proteins)-27b-3p]
an Enhancer box and a binding site for a cooperative co-activator of MyoD (show MYOD1 Proteins) are present in the promoter region of porcine PPARgamma.
The data suggest that there is local cooperation between resistin (show RETN Proteins) and PPARgamma expression in the porcine ovary. Resistin (show RETN Proteins) significantly increased the expression of PPARgamma, whereas PPARgamma decreased resistin (show RETN Proteins) expression; thus, PPARgamma is a new key regulator of resistin (show RETN Proteins) expression and function.
Therefore, this study demonstrated that the different regulatory adipogenic roles of MSTN (show MSTN Proteins) in ADSCs and MSCs act by differentially regulating PPARgamma and MyoD (show MYOD1 Proteins) expression.
PGRN (show GRN Proteins) inhibits adipogenesis in porcine preadipocytes partially through ERK (show MAPK1 Proteins) activation mediated PPARgamma phosphorylation.
Resveratrol activated sirtuin 1 (Sirt1 (show SIRT1 Proteins)) gene expression and increased adipose triglyceride lipase (ATGL (show PNPLA2 Proteins)) gene expression and glycerol release. Furthermore, this study found the opposite Sirt1 (show SIRT1 Proteins) regulation pattern for PPARgamma to that of ATGL (show PNPLA2 Proteins) in adipocytes.
The results indicate that the endometrial expression of PPARgamma genes fluctuates during the estrous cycle and pregnancy.
Increasing dietary DE linearly enhanced the expression of PPARgamma in adipose tissues but not skeletal muscle of Rongchang piglets.
Three novel SNPs of the bovine PPARgamma gene were identified in 514 individuals from six Chinese cattle breeds: SNP1 (AC_000179.1 g.57386668 C > G) in intron 2 and SNP2 (AC_000179.1 g.57431964 C > T) and SNP3 (AC_000179.1 g.57431994 T > C) in exon 7.
These results indicated that docosahexaenoic acid may attenuate lipopolysaccharide-stimulated inflammatory response in bovine mammary epithelial cells by suppressing NF-kappaB (show NFKB1 Proteins) activation through a mechanism partly dependent on PPARgamma activation.
PPARgamma is a positive regulator of milk fat synthesis in dairy cow mammary epithelial cells.
An Asp7Gly substitution in PPARG is associated with adiposity.
upregulation of PPARgamma was observed in the backfat tissue of Lilu cattle with increasing age
Co-culture of adipocytes and myoblasts elicited an increase in C/EBPbeta (show CEBPB Proteins) and PPAR-gamma gene expression in differentiated myoblasts and an increase in GPR43 (show FFAR2 Proteins) gene expression in adipocytes.
A potential association of an single nucleotide polymorphism (72472 GT in exon7) of the bovine PPAR-gamma gene with carcass and meat quality traits, was evaluated.
study demonstrates the co-expression of DLX3 (show DLX3 Proteins), PPARG and SP1 (show SP1 Proteins) in trophoblast binucleated cell(BNC)nuclei; this suggests a possible role of these transcription factors through BNC specific genes at the time of pre-placental differentiation
Single nucleotide polymorphisms in coding region of the PPARgamma gene, were examined.
oxidative stress attenuates PPAR gamma expression and activity in vascular endothelial cells
study found PPAR-gamma expression was prominent in the subthalamic nucleus, oculomotor nucleus, ventral tegmental nucleus, and to a lesser extent, in the putamen; 3 or 12 months after MPTP (show PTPN2 Proteins), only the lesioned putamen had increased PPAR-gamma
Aleglitazar, a dual PPARalpha (show PPARA Proteins)/gamma agonist, has beneficial effects on both lipid and glucose parameters in a primate model of the metabolic syndrome.
siRNA targeting PPARgamma gene can inhibit adipogenic differentiation of BMSCs and prevent steroid-induced osteonecrosis in rabbit.
vitamin E supplementation affords protection by decreasing MMP-1 (show MMP1 Proteins) and increasing PPARg, GSTa (show GSTa2 Proteins), and ABCA1 (show ABCA1 Proteins) levels in aortae of rabbits fed a cholesterol-rich diet
Telmisartan improves microvascular dysfunction during myocardial ischemia/reperfusion injury via the PPARgamma pathway.
PPARgamma plays a luteotropic role in pseudopregnant rabbits, through PTGS2 (show PTGS2 Proteins) down-regulation and 3beta-HSD (show HAL Proteins) up-regulation, with a consequent PGF2alpha decrease and progesterone increase.
In an animal model of atherosclerosis, the expression of PPAR-gamma is upregulated following atorvastatin administration.
Tongxinluo can inhibit the expression of MMP-3 (show MMP3 Proteins) and 9 and increase the expression of PPARgamma in atherosclerotic rabbits.
Niacin Reduces serum level and adipose mRNA expression of leptin (show LEP Proteins) and up-regulates PPARgamma and CD36 (show CD36 Proteins) mRNA expression in hypercholesterolemic rabbits.
Antidiabetic drug pioglitazone protects the heart via activation of PPAR-gamma receptors, PI3-kinase (show PIK3CA Proteins), Akt (show AKT1 Proteins), and eNOS (show NOS3 Proteins) pathway in a rabbit model of myocardial infarction.
This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described.
peroxisome proliferator activated receptor gamma
, peroxisome proliferative activated receptor gamma
, peroxisome proliferator-activated receptor gamma
, peroxisome proliferator activator receptor gamma
, nuclear receptor subfamily 1 group C member 3
, peroxisome proliferator activated receptor gamma 2
, peroxisome proliferator activated receptor gamma 4
, Nuclear receptor subfamily 1 group C member 3
, PPAR gamma
, peroxisome proliferator-activated nuclear receptor gamma variant 1
, peroxisome proliferator-activated receptor gamma 1
, peroxisome proliferator activator receptor, gamma
, PPAR gamma 2
, xPPAR gamma
, peroxisome proliferative activated receptor, gamma
, peroxisome proliferator-activated receptor gamma 2
, peroxisome proliferator-activated receptor gamma 1-a
, peroxisome proliferator-activated receptor gamma 1-b
, PPAR gamma 1
, peroxisome proliferator activated receptor gamma-1
, peroxisome proliferator-activated receptor-gamma