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For the first time, we report here the importance of GPER (show GPER Proteins)-PPARalpha (show PPARA Proteins) and -PPARgamma 'neopartnership' in maintenance of Leydig cell morpho-functional status.
Data show that a peroxisome proliferator activated receptor gamma (PPARgamma)-dependent adipogenic response regulates muscle fat infiltration during regeneration.
the intracellular domain of Lrp1 (show LRP1 Proteins) interacts with the nuclear receptor Ppargamma, a central regulator of lipid and glucose metabolism, acting as its transcriptional co-activator in endothelial cells.
High fat diet-induced obesity exacerbates hematopoiesis deficiency and cytopenia caused by 5-fluorouracil via peroxisome proliferator-activated receptor gamma.
findings suggest that MCAM (show MCAM Proteins) is a gene upregulated and involved in maintaining PPARgamma induction in the late but not in the early stages of 3T3-L1 fibroblasts adipogenesis.
This study shows that prolonged exposure to high-fat diets in adulthood is associated with a gradually increasing DNA methylation (show HELLS Proteins) level at the Leptin (show LEP Proteins) and Pparg2 promoters in a depot-specific manner.
Results suggest that hypothalamic peroxisome proliferator-activated receptor-gamma plays a vital role in ghrelin (show GHRL Proteins) production and food intake in mice.
Data suggest that expression of microRNA-128-3p is down-regulated during adipogenesis; an abundance of microRNA-128-3p appears to down-regulate adipogenesis and up-regulate lipolysis in adipocytes by targeting expression of Pparg (peroxisome proliferator-activated receptor gamma) and Sertad2 (SERTA domain-containing protein-2 (show SERTAD2 Proteins)).
The present study suggests for the first time that increased PPAR (show PPARA Proteins)-gmma expression by high fat diet is responsible for cardiac dysfunction via upregulation of mitochondrial enzymes HMGCS2 (show HMGCS2 Proteins), BDH1 (show BDH1 Proteins) and PDK4 (show PDK4 Proteins).
Data suggests that exposure to vitamin D deficiency during perinatal period directly affects expression of genes involved in development of adipose tissue in non-obese offspring; expression levels of Pparg (peroxisome proliferator activated receptor gamma) and Vdr (vitamin D receptor) are up-regulated in adipose tissue of male offspring.
Studies indicate that peroxisome proliferator activated receptor gamma (PPARgamma) expression is found in different regions of the kidney and, upon activation, can redirect metabolism [Review].
These results demonstrate that betaine acts through ERK1/2-PPARgamma signalling pathway to regulate lipid metabolism in adipogenic-differentiated skeletal muscle cells, which could provide some useful information for controlling muscle lipid accumulation by manipulating ERK1/2 and PPARgamma signalling pathway.
ALDH1A3 (show ALDH1A3 Proteins) suppression could be one of PPARG tumor suppressive function. This study provides a better understanding of the role of PPARG in lung cancer.
Regulation of transmembrane-4-L-six-family-1 (TM4SF1 (show TM4SF1 Proteins)) on bladder cancer cell could be induced by peroxisome proliferator-activated receptor gamma (PPARgamma)-sirtuin 1 (SIRT1 (show SIRT1 Proteins)) feedback loop.
The lack of PPARγ in recurrent miscarriage decidual macrophages seems to be associated with a specific inflammatory response against the fetus.
EDF1 (show EDF1 Proteins) is required for VEGF (show VEGFA Proteins)-induced activation of the transcriptional activity of PPARgamma in HUVEC cells.
Studied peroxisome proliferator-activated receptor-gamma gene (PPARgamma) single nucleotide polymorphisms (SNPs); found the SNPs to be associated with the occurrence or progression of sepsis.
This study suggests that T2D patients with different genotypes at CD36 (show CD36 Proteins), NOS3 and PPARG respond differentially to intervention of omega-3 supplements in blood lipid profiles.
ITLN1 (show ITLN1 Proteins), PPARg AND TNFa (show TNF Proteins) GENE EXPRESSION IN VISCERAL ADIPOSE TISSUE.
Gene expressions of YKL-40 (show CHI3L1 Proteins) and CD36 (show CD36 Proteins) were significantly higher in patients with T2DM (>5 yr) with hypertension compared to healthy controls (P=0.006). In addition, a significant increase in serum levels of sCD36, PPAR-gamma and YKL-40 (show CHI3L1 Proteins) was observed in patients with T2DM (>5 yr) with hypertension compared to healthy controls
Our results provide novel insights into regulation of PPAR (show PPARA Proteins) expression in ovarian follicles. We observed that FSH (show BRD2 Proteins) increased mRNA and protein expression of all PPARs isoforms, while LH only increased PPAR alpha (show PPARA Proteins) and gamma. Steroids like progesterone and estradiol increased expression of PPAR alpha (show PPARA Proteins) and gamma without affecting the beta isoform, while testosterone had no effect on all PPARs expression.
The results of the present study suggested that PPARG may mediate porcine placental angiogenesis, by interfering with hypoxia inducible factor, vascular endothelial growth factor (show VEGF Proteins) and angiopoietinmediated signaling.
The results suggest the higher expression of miR (show MYLIP Proteins)-130a, which targeting peroxisome proliferator-activated receptor gamma, may be the reason for less fat deposition in intramuscular adipose tissue than subcutaneous adipose tissue.
The immunoprecipitation results also showed that high AA concentrations significantly increased the interaction of mTOR (show FRAP1 Proteins) and PPARg. In summary, PPARg plays an important role in the regulation of IGF-1 (show IGF1 Proteins) secretion and gene expression in response to dietary protein.
The regulatory role of microRNA miR (show MYLIP Proteins)-27b-3p on peroxisome proliferator-activated receptor-gamma (PPARgamma) was confirmed by their inversed expression patterns in oocytes: [miR (show MYLIP Proteins)-27b-3p]
an Enhancer box and a binding site for a cooperative co-activator of MyoD (show MYOD1 Proteins) are present in the promoter region of porcine PPARgamma.
The data suggest that there is local cooperation between resistin (show RETN Proteins) and PPARgamma expression in the porcine ovary. Resistin (show RETN Proteins) significantly increased the expression of PPARgamma, whereas PPARgamma decreased resistin (show RETN Proteins) expression; thus, PPARgamma is a new key regulator of resistin (show RETN Proteins) expression and function.
Therefore, this study demonstrated that the different regulatory adipogenic roles of MSTN (show MSTN Proteins) in ADSCs and MSCs act by differentially regulating PPARgamma and MyoD (show MYOD1 Proteins) expression.
PGRN (show GRN Proteins) inhibits adipogenesis in porcine preadipocytes partially through ERK (show MAPK1 Proteins) activation mediated PPARgamma phosphorylation.
Resveratrol activated sirtuin 1 (Sirt1 (show SIRT1 Proteins)) gene expression and increased adipose triglyceride lipase (ATGL (show PNPLA2 Proteins)) gene expression and glycerol release. Furthermore, this study found the opposite Sirt1 (show SIRT1 Proteins) regulation pattern for PPARgamma to that of ATGL (show PNPLA2 Proteins) in adipocytes.
Three novel SNPs of the bovine PPARgamma gene were identified in 514 individuals from six Chinese cattle breeds: SNP1 (AC_000179.1 g.57386668 C > G) in intron 2 and SNP2 (AC_000179.1 g.57431964 C > T) and SNP3 (AC_000179.1 g.57431994 T > C) in exon 7.
These results indicated that docosahexaenoic acid may attenuate lipopolysaccharide-stimulated inflammatory response in bovine mammary epithelial cells by suppressing NF-kappaB (show NFKB1 Proteins) activation through a mechanism partly dependent on PPARgamma activation.
PPARgamma is a positive regulator of milk fat synthesis in dairy cow mammary epithelial cells.
An Asp7Gly substitution in PPARG is associated with adiposity.
upregulation of PPARgamma was observed in the backfat tissue of Lilu cattle with increasing age
Co-culture of adipocytes and myoblasts elicited an increase in C/EBPbeta (show CEBPB Proteins) and PPAR-gamma gene expression in differentiated myoblasts and an increase in GPR43 (show FFAR2 Proteins) gene expression in adipocytes.
A potential association of an single nucleotide polymorphism (72472 GT in exon7) of the bovine PPAR-gamma gene with carcass and meat quality traits, was evaluated.
study demonstrates the co-expression of DLX3 (show DLX3 Proteins), PPARG and SP1 (show SP1 Proteins) in trophoblast binucleated cell(BNC)nuclei; this suggests a possible role of these transcription factors through BNC specific genes at the time of pre-placental differentiation
Single nucleotide polymorphisms in coding region of the PPARgamma gene, were examined.
oxidative stress attenuates PPAR gamma expression and activity in vascular endothelial cells
study found PPAR-gamma expression was prominent in the subthalamic nucleus, oculomotor nucleus, ventral tegmental nucleus, and to a lesser extent, in the putamen; 3 or 12 months after MPTP (show PTPN2 Proteins), only the lesioned putamen had increased PPAR-gamma
Aleglitazar, a dual PPARalpha (show PPARA Proteins)/gamma agonist, has beneficial effects on both lipid and glucose parameters in a primate model of the metabolic syndrome.
the present study demonstrated that RS protects primary myocardial cells against OGD (show FGFR1 Proteins)/R injury by regulating PPARgamma and UCP2 (show UCP2 Proteins). RS may be a promising therapeutic agent for treatment of myocardial ischemia/reperfusion injury.
siRNA targeting PPARgamma gene can inhibit adipogenic differentiation of BMSCs and prevent steroid-induced osteonecrosis in rabbit.
vitamin E supplementation affords protection by decreasing MMP-1 (show MMP1 Proteins) and increasing PPARg, GSTa (show GSTa2 Proteins), and ABCA1 (show ABCA1 Proteins) levels in aortae of rabbits fed a cholesterol-rich diet
Telmisartan improves microvascular dysfunction during myocardial ischemia/reperfusion injury via the PPARgamma pathway.
PPARgamma plays a luteotropic role in pseudopregnant rabbits, through PTGS2 (show PTGS2 Proteins) down-regulation and 3beta-HSD (show HAL Proteins) up-regulation, with a consequent PGF2alpha decrease and progesterone increase.
In an animal model of atherosclerosis, the expression of PPAR-gamma is upregulated following atorvastatin administration.
Tongxinluo can inhibit the expression of MMP-3 (show MMP3 Proteins) and 9 and increase the expression of PPARgamma in atherosclerotic rabbits.
Niacin Reduces serum level and adipose mRNA expression of leptin (show LEP Proteins) and up-regulates PPARgamma and CD36 (show CD36 Proteins) mRNA expression in hypercholesterolemic rabbits.
Antidiabetic drug pioglitazone protects the heart via activation of PPAR-gamma receptors, PI3-kinase (show PIK3CA Proteins), Akt (show AKT1 Proteins), and eNOS (show NOS3 Proteins) pathway in a rabbit model of myocardial infarction.
This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described.
peroxisome proliferator activated receptor gamma
, peroxisome proliferative activated receptor gamma
, peroxisome proliferator-activated receptor gamma
, peroxisome proliferator activator receptor gamma
, nuclear receptor subfamily 1 group C member 3
, peroxisome proliferator activated receptor gamma 2
, peroxisome proliferator activated receptor gamma 4
, Nuclear receptor subfamily 1 group C member 3
, PPAR gamma
, peroxisome proliferator-activated nuclear receptor gamma variant 1
, peroxisome proliferator-activated receptor gamma 1
, peroxisome proliferator activator receptor, gamma
, PPAR gamma 2
, xPPAR gamma
, peroxisome proliferative activated receptor, gamma
, peroxisome proliferator-activated receptor gamma 2
, peroxisome proliferator-activated receptor gamma 1-a
, peroxisome proliferator-activated receptor gamma 1-b
, PPAR gamma 1
, peroxisome proliferator activated receptor gamma-1
, peroxisome proliferator-activated receptor-gamma