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The NLRP3 inflammasome is upregulated in activated astrocytes. HMGB1 could effectively promote NLRP3 inflammasome formation in astrocytes, by activating NF-kappaB. IL4 could inhibit NLRP3 inflammasome formation, through negative regulation NF-kappaB and promotion PPARgamma activation.
Results strongly suggest that, the inhibition of ATE1 enzyme or knockout of Ate1 gene in pre-adipocytes can suppress adipogenesis via regulation of PPARgamma expression at transcript as well as protein level.
PPARg and APC respectively contributed to microRNA-27a-decreased osteoclast differentiation and bone resorption. Taken together, these results showed that microRNA-27a may play a significant role in the process of estrogen-inhibited osteoclast differentiation and function.
MAGED1 bound to PPARgamma and suppressed the stability and transcriptional activity of PPARgamma.
Authors show that ablation of the nuclear receptor PPARgamma specifically in inguinal fat tissue in aging mice is associated with increased fat tissue expansion and insulin resistance. These metabolic effects are accompanied by decreased thermogenesis, reduced levels of brown fat genes, and browning of subcutaneous adipose tissue.
It was confirmed that PRMT6 was involved in the process of adipocyte differentiation. In addition, PRMT6 interacted with, but did not methylate, PPARgamma. PRMT6 bound to the PPARresponsive regulatory element of the adipocyte Protein 2 (aP2) promoter in conjunction with PPARgamma and generated the repressive epigenetic mark arginine 2 on histone H3 asymmetric dimethylation, which suppressed aP2 gene expression.
conclude that RBP7 is required to mediate the protective effects of PPARgamma in the endothelium through adiponectin, and RBP7 is an endothelium-specific PPARgamma target and regulator of PPARgamma activity
camel whey protein supplemented heat stress (HS) mice exhibited complete restoration of Bcl2, P53, Nrf2, and PPAR-gamma expressions; testicular Leydig cell distribution; significant higher levels of testosterone levels; and hence higher percentages of progressively motile sperm and lower percentages of immotile sperm as compared to HS mice.
this study shows that PPARgamma deficiency suppresses the release of IL-1beta and IL-1alpha in macrophages via a type 1 IFN-dependent mechanism
PPARgamma deficiency in perivascular adipose tissue, while still expressed in vascular smooth muscle cell, enhances atherosclerosis and results in vascular and systemic inflammation.
Molecular docking analysis revealed that the inhibitory activity of these phenolic compounds over the early stages of adipogenesis exhibits a significant correlation (r = 0.7034; p = 0.005) with their binding affinity to the ligand-binding domain of PPARgamma.
PPARgamma would play critical roles on myoblasts differentiation, mediating crosstalk among several pathways and transcription factors.
miR-27-3p mediated alveolar macrophage activation by the inhibition of PPARgamma activation and sensitization of TLR signaling.
study showing AEC-PPARgamma's role as a transcriptional repressor of MUC5AC highlights this receptor's potential as a pharmacological target for asthma.
Resveratrol displayed significant anti-adipogenic activities as exhibited by the ability to antagonize PPARgamma-dependent adipocyte differentiation, down-regulate genes involved in lipid metabolism, block cofactor recruitment to PPARgamma, and antagonize the effects of the PPARgamma agonist rosiglitazone. In contrast, genistein and daidzein functioned as PPARgamma agonists while also displaying pro-adipogenic activities.
a significant decrease in the expression of peroxisome proliferator-activated receptor-gamma (PPARgamma) in calcified arteries both in chronic kidney disease (CKD) patients and in a mouse model of CKD with hyperphosphatemia, is reported.
PPAR-gamma deficiency in vascular smooth muscle increases pulmonary vascular muscularization.
These results demonstrate that both natural and synthetic PPARgamma ligands capable of suppressing Foxp3 expression in activated nTreg cells of NOD and NOR mice.
These findings demonstrate the crucial role of PIAS1-mediated PPARgamma SUMOylation in protecting against myocardial ischemia-reperfusion injury.
The transcription factor PPAR-gamma is a key regulator of lung immunity exhibiting multiple cell type specific roles in controlling development and function of the lung immune system. Review.
our results provide novel insights into the pivotal role of JMJD2B in the development of hepatic steatosis through upregulation of PPARg2 and steatosis target genes.
our results indicate a significant association between the Pro12Ala genotype of PPARG and an increased rate of cognitive decline among older black males but not among black females, white males, or white females.
Severely obese individuals carrying the Ala allele of the PPARG2 Pro12Ala polymorphism had higher measures of adiposity and blood pressure, while no important associations were found for the IL6 -174G >C polymorphism.
our findings describing the molecular mechanisms involving GPx3 and PPARgamma in CSE-induced oxidative stress and inflammation may provide valuable information for the development of more effective therapeutics for chronic obstructive pulmonary disease (COPD)
PPARG Pro12Ala polymorphism (rs1801282) is associated with metabolic syndrome components and may modulate the biological response of dietary fat intake on body mass index and triglyceride levels.
The C/C genotype of the PPAR-gamma rs1801282 variant entails elevated blood pressure in middle aged women.
Results suggest that the expression and activity of peroxisome proliferator-activated receptors (PPARs) in peripheral blood mononuclear cells (PBMCs) varies with respect to signal transducer and activator of transcription STAT1 and STAT6 trafficking in diabetic patients with and without cardiovascular diseases.
The protective mechanisms of peroxisome proliferator-activated receptor gamma Pro12Ala polymorphism in type 2 diabetes are unclear. No major differences in adipose tissue differentiation, glucose uptake, lipolysis or expression of PPARgamma target genes were observed between different PPARgamma Pro12Ala genotypes.
PPARgamma could be involved in the potential mechanisms for apo-10'-lycopenoic acid protecting against tumor progression
Subjects with the Pro12Ala polymorphism (rs1801282) were studied. Subjects with higher vitamin E intake levels and the Pro12Ala/Ala12Ala genotype had statistically significant higher levels of serum adiponectin than subjects with the Pro12Pro genotype (4.4 [3.2-5.7] vs. 2.7 [2.0-3.5] mug/mL; p = 0.024).
Data indicate that PPAR-g agonists represent an attractive treatment tool and by suppression of cell growth (in vitro and ex vivo models) and of invasion via blockade of MAPK cascade and TGFb/SMADs signaling, respectively, and its role in cancer bioenergetics and metabolism indicate that PPAR-g agonists represent an attractive treatment tool for non small cell lung cancer .
Study shows a lack of associations between polymorphisms in SOD2 (rs2758331), NOS3 (rs1808593), PPARdelta (rs9794 and rs10865710) and the risk of osteoarthritis in a Chinese Han population: a case-control study.
The Ala allele of PPARgamma2 appears to have a protective effect against hypertension and a dominant function [meta-analysis]
Study suggests the association between PPARG rs1801282 G allele and unstable angina in Polish population.
Studied effect of docosahexaenoic acid (DHA) enriched fish oil on upregulation and activity of cyclin dependent kinase inhibitor 2A (CDKN2A), telomerase, and peroxisome proliferator activated receptor gamma (PPARG) in type 2 diabetes mellitus patients.
Loss of PPARgamma diminishes PGC1alpha and stimulates derangements in mitochondrial structure and function that cause pulmonary artery smooth muscle cell proliferation.
PPARG promotes apoptosis and suppresses cell proliferation in clear cell renal carcinoma cells by inhibiting Six2.
Downregulation of peroxisome proliferator-activated receptor gamma in the placenta is associated with hyperglycemia in offspring at young adulthood after exposure to gestational diabetes mellitus.
PPARgamma is a key regulator of primary adipose tissue microvascular endothelial cell (ATEC) function including fatty acid handling and inflammatory response. The outcome of PPARgamma activation is modulated by senescence, a phenomenon that may impact the ability of hATEC to properly respond to and handle lipid fluxes.
Functional Variant of C-689T in the Peroxisome Proliferator-Activated Receptor-gamma2 Promoter is Associated with Coronary Heart Disease in Chinese Nondiabetic Han People.
Study demonstrated that overexpression of DNMT3A promoted the expression of cell proliferation markers but significantly decreased the expression of p21 to repress cell proliferation by the methylation of p21 promoter. Moreover, overexpression of DNMT3A decreased lipid accumulation and significantly down-regulated the levels of adipogenic marker genes through the methylation of PPARg promoter.
Our results provide novel insights into regulation of PPAR expression in ovarian follicles. We observed that FSH increased mRNA and protein expression of all PPARs isoforms, while LH only increased PPAR alpha and gamma. Steroids like progesterone and estradiol increased expression of PPAR alpha and gamma without affecting the beta isoform, while testosterone had no effect on all PPARs expression.
The results of the present study suggested that PPARG may mediate porcine placental angiogenesis, by interfering with hypoxia inducible factor, vascular endothelial growth factor and angiopoietinmediated signaling.
The results suggest the higher expression of miR-130a, which targeting peroxisome proliferator-activated receptor gamma, may be the reason for less fat deposition in intramuscular adipose tissue than subcutaneous adipose tissue.
The immunoprecipitation results also showed that high AA concentrations significantly increased the interaction of mTOR and PPARg. In summary, PPARg plays an important role in the regulation of IGF-1 secretion and gene expression in response to dietary protein.
The regulatory role of microRNA miR-27b-3p on peroxisome proliferator-activated receptor-gamma (PPARgamma) was confirmed by their inversed expression patterns in oocytes: [miR-27b-3p]
an Enhancer box and a binding site for a cooperative co-activator of MyoD are present in the promoter region of porcine PPARgamma.
The data suggest that there is local cooperation between resistin and PPARgamma expression in the porcine ovary. Resistin significantly increased the expression of PPARgamma, whereas PPARgamma decreased resistin expression; thus, PPARgamma is a new key regulator of resistin expression and function.
Therefore, this study demonstrated that the different regulatory adipogenic roles of MSTN in ADSCs and MSCs act by differentially regulating PPARgamma and MyoD expression.
PGRN inhibits adipogenesis in porcine preadipocytes partially through ERK activation mediated PPARgamma phosphorylation.
Resveratrol activated sirtuin 1 (Sirt1) gene expression and increased adipose triglyceride lipase (ATGL) gene expression and glycerol release. Furthermore, this study found the opposite Sirt1 regulation pattern for PPARgamma to that of ATGL in adipocytes.
The results indicate that the endometrial expression of PPARgamma genes fluctuates during the estrous cycle and pregnancy.
Increasing dietary DE linearly enhanced the expression of PPARgamma in adipose tissues but not skeletal muscle of Rongchang piglets.
These results suggest that trans-10, cis-12-conjugated linoleic acid can modulate TNF-alpha production and NF-kappa B expression by a PPARgamma-dependent pathway in porcine peripheral blood mononuclear cells.
The results indicated that PPARgamma gene was significantly associated with litter size in pigs.
Results indicated that PPARgamma is an essential regulatory factor for the transcriptional activity of ERp44, which in turn controls the secretion of adiponectin.
Endothelium on the pathosusceptible side of the aortic valve leaflet is responds to hypercholesterolemia with activation of a PPAR-gamma pathway.
PPAR profiles in bladder smooth muscle (BSM) may contribute to the susceptibility of BSM to lipotoxicity in the metabolic syndrome.
Our results raise doubts about the prevalently accepted anti-inflammatory role for PPAR-g activation.
Upregulation of PPAR-gamma and NADPH oxidases are involved in restenosis.
This study shows that bta-miR-130a and bta-miR-130b play similar roles in the regulation of adipocyte differentiation in beef muscles by targeting the 3'UTR of PPARG and CYP2U1.
Results found that PPAR-gamma expression is regulated by miR-454 in bovine mammary epithelial cells (BMECs). miR-454 directly targets the 3'UTR of PPAR-gamma to regulate triglyceride synthesis in BMECs.
Three novel SNPs of the bovine PPARgamma gene were identified in 514 individuals from six Chinese cattle breeds: SNP1 (AC_000179.1 g.57386668 C > G) in intron 2 and SNP2 (AC_000179.1 g.57431964 C > T) and SNP3 (AC_000179.1 g.57431994 T > C) in exon 7.
These results indicated that docosahexaenoic acid may attenuate lipopolysaccharide-stimulated inflammatory response in bovine mammary epithelial cells by suppressing NF-kappaB activation through a mechanism partly dependent on PPARgamma activation.
PPARgamma is a positive regulator of milk fat synthesis in dairy cow mammary epithelial cells.
An Asp7Gly substitution in PPARG is associated with adiposity.
upregulation of PPARgamma was observed in the backfat tissue of Lilu cattle with increasing age
Co-culture of adipocytes and myoblasts elicited an increase in C/EBPbeta and PPAR-gamma gene expression in differentiated myoblasts and an increase in GPR43 gene expression in adipocytes.
A potential association of an single nucleotide polymorphism (72472 GT in exon7) of the bovine PPAR-gamma gene with carcass and meat quality traits, was evaluated.
study demonstrates the co-expression of DLX3, PPARG and SP1 in trophoblast binucleated cell(BNC)nuclei; this suggests a possible role of these transcription factors through BNC specific genes at the time of pre-placental differentiation
Single nucleotide polymorphisms in coding region of the PPARgamma gene, were examined.
oxidative stress attenuates PPAR gamma expression and activity in vascular endothelial cells
The effects of dietary fat components on the expression of PPAR-gamma AND PPAR-gamma coactivator 1 in cultured bovine preadipocytes are reported.
Intramammary infection elicited a strong transcriptomic response, leading to potent activation of pro-inflammatory pathways that were associated with a marked inhibition of lipid synthesis, stress-activated kinase signaling cascades, and PPAR signaling.
PPARgamma1 has bifunctional properties in the regulation of KDR gene expression mediated via interaction with both Sp1 and Sp3
There is evidence of cotranscription and intergenic splicing events between the PPARG gene and the neighboring gene TSEN2 in cattle. Two types of chimeric transcripts are observed.
study found PPAR-gamma expression was prominent in the subthalamic nucleus, oculomotor nucleus, ventral tegmental nucleus, and to a lesser extent, in the putamen; 3 or 12 months after MPTP, only the lesioned putamen had increased PPAR-gamma
Aleglitazar, a dual PPARalpha/gamma agonist, has beneficial effects on both lipid and glucose parameters in a primate model of the metabolic syndrome.
the present study demonstrated that RS protects primary myocardial cells against OGD/R injury by regulating PPARgamma and UCP2. RS may be a promising therapeutic agent for treatment of myocardial ischemia/reperfusion injury.
siRNA targeting PPARgamma gene can inhibit adipogenic differentiation of BMSCs and prevent steroid-induced osteonecrosis in rabbit.
vitamin E supplementation affords protection by decreasing MMP-1 and increasing PPARg, GSTa, and ABCA1 levels in aortae of rabbits fed a cholesterol-rich diet
Telmisartan improves microvascular dysfunction during myocardial ischemia/reperfusion injury via the PPARgamma pathway.
PPARgamma plays a luteotropic role in pseudopregnant rabbits, through PTGS2 down-regulation and 3beta-HSD up-regulation, with a consequent PGF2alpha decrease and progesterone increase.
In an animal model of atherosclerosis, the expression of PPAR-gamma is upregulated following atorvastatin administration.
Tongxinluo can inhibit the expression of MMP-3 and 9 and increase the expression of PPARgamma in atherosclerotic rabbits.
Niacin Reduces serum level and adipose mRNA expression of leptin and up-regulates PPARgamma and CD36 mRNA expression in hypercholesterolemic rabbits.
Antidiabetic drug pioglitazone protects the heart via activation of PPAR-gamma receptors, PI3-kinase, Akt, and eNOS pathway in a rabbit model of myocardial infarction.
This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described.
peroxisome proliferator activated receptor gamma
, peroxisome proliferative activated receptor gamma
, peroxisome proliferator-activated receptor gamma
, peroxisome proliferator activator receptor gamma
, nuclear receptor subfamily 1 group C member 3
, peroxisome proliferator activated receptor gamma 2
, peroxisome proliferator activated receptor gamma 4
, Nuclear receptor subfamily 1 group C member 3
, PPAR gamma
, peroxisome proliferator-activated nuclear receptor gamma variant 1
, peroxisome proliferator-activated receptor gamma 1
, peroxisome proliferator activator receptor, gamma
, PPAR gamma 2
, xPPAR gamma
, peroxisome proliferative activated receptor, gamma
, peroxisome proliferator-activated receptor gamma 2
, peroxisome proliferator-activated receptor gamma 1-a
, peroxisome proliferator-activated receptor gamma 1-b
, PPAR gamma 1
, peroxisome proliferator activated receptor gamma-1
, peroxisome proliferator-activated receptor-gamma