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Data suggest that millisecond dynamic changes in PDZ1 domain conformation are responsible for higher affinity of scribble (show SCRIB Proteins) PDZ1 for phosphorylated ligands; oligopeptide fragments of RPS6KA2 and MCC (show MCC Proteins) were used as ligands in these nuclear magnetic resonance chemical shift experiments. (RPS6KA2 = ribosomal protein S6 kinase 2 (show RPS6KA3 Proteins); MCC (show MCC Proteins) = mutated in colorectal cancer protein)
RSK1 (show RPS6KA1 Proteins) and 3 but not RSK2 (show RPS6KA3 Proteins) are down-regulated in breast tumour and are associated with disease progression. RSK (show RPS6KA1 Proteins) may be a key component in the progression and metastasis of breast cancer.
Data indicate that S6 kinase 2 (S6K2 (show RPS6KB2 Proteins)) can phosphorylate histone H3 (show HIST3H3 Proteins) at position Thr45, which may play a role during cell proliferation and/or differentiation.
Kinome screening revealed RPS6KA2 expression, in human pancreatic cancer cells, protects against erlotinib induced apoptosis.
genetic association study in Han population in China: Data suggest that SNPs in RSK3 (rs2229712) and in MEK1 (show MAP2K1 Proteins) (rs28730804) demonstrate gene-gene interaction that affects antidepressant drug outcome in female patients with major depressive disorder.
Overexpression of RSK3 or RSK4 (show RPS6KA6 Proteins) supports tumor cell proliferation upon PI3K (show PIK3CA Proteins) inhibition both in vitro and in vivo therby contributing to drug resistance.
p90RSK2 is dispensable for BCR-ABL (show ABL1 Proteins)-induced myeloid leukemia (show BCL11A Proteins), but may be required for pathogenesis and lineage determination in FLT3 (show FLT3 Proteins)-internal tandem duplication-induced hematopoietic transformation.
Data show that genetic variation in RPS6KA1 (show RPS6KA1 Proteins), RPS6KA2, and PRS6KB2 were associated with risk of developing colon cancer while only genetic variation in RPS6KA2 was associated with altering risk of rectal cancer.
Characterization of the terminal domain as a protein kinase
chronic activation CREB (show CREB1 Proteins) and p90RSK (show RPS6KA1 Proteins) in the epileptic hippocampus may be closely associated with the histopathological changes of Ammon's horn sclerosis
We confirmed that Raf1 (show RAF1 Proteins)(L613V) knock-in confers a NS-like phenotype, including cardiac hypertrophy. Active RSK3 was increased in Raf1 (show RAF1 Proteins)(L613V) mice. Constitutive RSK3 gene deletion prevented the Raf1 (show RAF1 Proteins)(L613V)-dependent concentric growth in width of the cardiac myocyte and attenuated cardiac hypertrophy in female mice.
RSK3 is required for the induction of interstitial cardiac fibrosis in alpha-tropomyosin (show TPM1 Proteins) Glu180Gly transgenic mice.
Anchored RSK3 transduces signals that modulate pathologic myocyte growth in cardiac hypertrophy.
p90RSK2 is dispensable for BCR-Abl (show ABL1 Proteins)-induced myeloid leukemia (show BCL11A Proteins), but may be required for pathogenesis and lineage determination in Flt3 (show FLT3 Proteins)-internal tandem duplication-induced hematopoietic transformation.
activation and translocation of p90 (show GPAM Proteins) ribosomal S6 protein kinase (show CDK7 Proteins) requires RANTES (show CCL5 Proteins)-mediated chemokine (show CCL1 Proteins) transcription in astrocytes
p90Rsk2 and Emi1 functionally interact during oocyte maturation
inhibition of p90RSK (show RPS6KA1 Proteins) prevented H2O2-mediated cTnI (show TNNC1 Proteins) (Ser (show SIGLEC1 Proteins)(23/24)) phosphorylation but not ERK1/2 and PKCalpha (show PKCa Proteins)/betaII activation
p90RSK (show RPS6KA1 Proteins) is a novel regulator of cardiac NHE1 (show SLC9A1 Proteins) activity by phosphorylating NHE1 (show SLC9A1 Proteins) serine 703 and a new pathological mediator of I/R injury in the heart
there is a functional link between S6K1 (show RPS6KB1 Proteins) II and CK2 (show CSNK2A1 Proteins) signaling, which involves the regulation of S6K1 (show RPS6KB1 Proteins) II nuclear export by CK2 (show CSNK2A1 Proteins)-mediated phosphorylation of Ser (show SIGLEC1 Proteins)-17
RSK2 (show RPS6KA3 Proteins) is a key regulator for cell transformation induced by tumor promoters such as EGF (show EGF Proteins) and TPA (show PLAT Proteins).
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
ribosomal protein S6 kinase alpha-2
, ribosomal protein S6 kinase, 90kD, polypeptide 2
, 90 kDa ribosomal protein S6 kinase 2
, MAP kinase-activated protein kinase 1c
, MAPK-activated protein kinase 1c
, MAPKAP kinase 1c
, p90-RSK 2
, ribosomal S6 kinase 3
, ribosomal protein S6 kinase alpha 2
, S6K-alpha 2
, protein-tyrosine kinase Mpk-9