anti-Human Cytochrome P450, Family 19, Subfamily A, Polypeptide 1 antibody for Enzyme Immunoassay

Recommended Cytochrome P450, Family 19, Subfamily A, Polypeptide 1 Antibody

Antigen
Cytochrome P450, Family 19, Subfamily A, Polypeptide 1 (CYP19A1) Antibodies
  • ARO
  • ARO1
  • CPV1
  • CYAR
  • CYP19
  • CYPXIX
  • P-450AROM
  • Aromatase
  • Cyp19
  • Cyp19a
  • p450arom
  • P450 arom
  • aro
  • cyp19
  • cyp19a
  • p450arom-A
  • P450AROM
  • Ar
  • ArKO
  • Int-5
  • Int5
  • CYP19P1
  • CYP19A1
  • CYP19a1
  • P450aromA
  • ar1
  • cypXIX
  • etID309862.18
  • zgc:136541
  • cyp19a1
  • cytochrome P450 family 19 subfamily A member 1
  • cytochrome P450, family 19, subfamily a, polypeptide 1
  • cytochrome P450 family 19 subfamily A member 1 L homeolog
  • aromatase
  • cytochrome P450 aromatase
  • cytochrome P450, family 19, subfamily A, polypeptide 1
  • cytochrome P450 19A1
  • cytochrome P450, family 17, subfamily A, polypeptide 1
  • cytochrome P450, family 19
  • cytochrome P450, family 19, subfamily A, polypeptide 1a
  • cytochrome P450 19A1-like
  • CYP19A1
  • Cyp19a1
  • cyp19a1.L
  • SAV_2383
  • pfcyp19b-tstr
  • CYP19
  • cyp19a1a
  • LOC101174651
Epitope
AA 461-491, C-Term
22
18
16
6
5
3
3
3
3
3
2
2
2
2
2
2
2
1
1
1
1
Reactivity
Human
160
86
60
7
6
5
5
4
4
3
3
2
2
2
2
1
1
1
Host
Rabbit
128
24
21
Clonality
Polyclonal
Conjugate
Un-conjugated
6
4
4
4
4
4
4
4
3
2
2
2
2
2
2
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
122
60
52
31
26
19
14
7
7
6
4
3
Options

Available images

Catalog No. ABIN359737
$ 484.00
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Clonality References Details
7 ABIN614909 EIA IHC (p) WB Goat Internal Region Polyclonal 0
4 ABIN359546 EIA WB Rabbit Ig Fraction AA 230-259, Middle Region Polyclonal 2

General

Antigen Cytochrome P450, Family 19, Subfamily A, Polypeptide 1 (CYP19A1) Antibodies
Epitope AA 461-491, C-Term
(22), (18), (16), (6), (5), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1)
Reactivity Human
(160), (86), (60), (7), (6), (5), (5), (4), (4), (3), (3), (2), (2), (2), (2), (1), (1), (1)
Host Rabbit
(128), (24), (21)
Clonality
Polyclonal
Conjugate Un-conjugated
(6), (4), (4), (4), (4), (4), (4), (4), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1)
Application Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(122), (60), (52), (31), (26), (19), (14), (7), (7), (6), (4), (3)
Pubmed 2 references available
Supplier

Product details

Target Details Application Details Handling References Images
Specificity This antibody detects Aromatase (CYP19A1) at C-term.
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS
Immunogen KLH conjugated synthetic peptide between 461~491 amino acids from the C-terminal region of Human CYP19A1. Genename: CYP19A1
Isotype Ig Fraction

Target Details

Product details Application Details Handling References Images back to top
Antigen
Alternative Name Aromatase (CYP19A1 Antibody Abstract)
Background CYP19A1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis, three successive hydroxylations of the A ring of androgens. Mutations in the gene encoding CYP19A1 can result in either increased or decreased aromatase activity, the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation.Synonyms: ARO1, CYAR, CYP19, CYP19A1, CYPXIX, Cytochrome P450 19A1, Estrogen synthetase, P450AROM
Molecular Weight 57883 Da
Gene ID 1588, 9606
UniProt P11511
Pathways Metabolism of Steroid Hormones and Vitamin D, Steroid Hormone Biosynthesis, C21-Steroid Hormone Metabolic Process, Carbohydrate Homeostasis

Application Details

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Application Notes ELISA: 1/1,000. Western blot: 1/50-1/100. Immunohistochemistry on Paraffin Sections: 1/10-1/50.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only

Handling

Product details Target Details Application Details References Images back to top
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

References

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Background publications

Xita, Georgiou, Lazaros, Psofaki, Kolios, Tsatsoulis: "The synergistic effect of sex hormone-binding globulin and aromatase genes on polycystic ovary syndrome phenotype." in: European journal of endocrinology / European Federation of Endocrine Societies, Vol. 158, Issue 6, pp. 861-5, 2008

Meinsma, Fernandez-Salguero, Van Kuilenburg, Van Gennip, Gonzalez: "Human polymorphism in drug metabolism: mutation in the dihydropyrimidine dehydrogenase gene results in exon skipping and thymine uracilurea." in: DNA and cell biology, Vol. 14, Issue 1, pp. 1-6, 1995

Images

Product details Target Details Application Details Handling References back to top
Supplier Images
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Cytochrome P450, Family 19, Subfamily A, Polypeptide 1 (CYP19A1) (AA 461-491), (C-Term) antibody (ABIN359737) AP14221PU-N CYP19A1 antibody staining of Formalin-Fixed, Paraffin-Embedded Human plac...
Western Blotting (WB) image for anti-Cytochrome P450, Family 19, Subfamily A, Polypeptide 1 (CYP19A1) (AA 461-491), (C-Term) antibody (ABIN359737) Western blot analysis using AP14221PU-N CYP19A1 antibody in Jurkat cell line lysates ...