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This study identified GATA motifs as essential control elements for HSD3B1 transcription and GATA2 as a novel transcriptional regulator of HSD3B1 expression in the human placenta.
High HSD3B1 Expression is Associated with Cancer Progression in Breast Cancer.
Fungicide ziram may disrupt the placental steroid production. In the present study, we investigated the effects of ziram on steroid formation in human placental cell line JEG-3 cells and on HSD3B1 and aromatase in the human placenta. Ziram did not inhibit progesterone production in JEG-3 cells and HSD3B1 activity at 100muM... ziram is a potent inhibitor of human aromatase.
This is the first study to indicate that 3beta-HSD type 1 is a potent prognostic factor in hormone-dependent breast cancer.
HSD3B1 is involved in aldosterone production, despite its lower levels of expression compared with HSD3B2, and also possibly associated with KCNJ5 mutation in aldosterone-producing adenoma.
Expression of the genes HSD3B1, HSD17B3, and SRD5A2 was significantly increased in BPH tissues compared to normal adjacent prostate tissues.
prostate cancer patients who harbored the heterozygous variant HSD3B1 (1245C) are more likely to develop to castration-resistant prostate cancer but do not have shorter time to biochemical recurrence, shorter survival time or higher mortality risk
No evidence to support that HSD3B1 is involved in aldosterone synthesis in the human adrenal cortex or that genetic variation in HSD3B1 affects blood pressure or hypertension.
Results indicate that orexin-A significantly enhanced the expression of 3beta-hydroxysteroid dehydrogenase (3beta-HSD) and the production of cortisol, and increased the phosphorylation of AKT protein in the NCI-H295R adrenocortical cells.
The data of this study supports a strongly positive association between mitochondrial complex I gene variations and MS pathogenesis in a Filipino population.
The AngII-NGFIB/NURR1 pathway controls HSD3B1 expression.
The AAT haplotype of the HSD3B1 gene was significantly associated with increased risks of acne vulgaris in Han Chinese from the Southwest China.
HSD3B1 T-->C Leu338, HTR2A T102C, GNAS T393C, and RGS2 G638A polymorphisms were not associated with hypertension risk.
Risk-conferring genetic variations in the HSD3beta gene influenced susceptibility of primary aldosteronism. Concomitant presence of rs6203 CC and rs12410453 GA genotypes synergistically increased aldosterone-to-renin ratio
Study shows that castration-resistant prostate cancer sometimes expresses a gain-of-stability mutation that leads to a gain-of-function in 3betaHSD1, which catalyzes the initial rate-limiting step in conversion of the adrenal-derived steroid dehydroepiandrosterone to dihydrotestosterone.
elevated in placental tissue of women with polycystic ovarian syndrome
HSD3B1 is a highly specific trophoblast-associated marker that can be used in the distinction of trophoblastic tumorlike lesions and tumors from nontrophoblastic lesions and tumors.
The aim of this haplotype-based case-control study was to estimate whether polymorphisms of the maternal estrogen synthesis genes (CYP19A1, HSD3B1 and HSD3B2) are associated with preeclampsia and gestational hypertension
Carriers of HSD3B1 GCC haplotype had lower peak early (Ea; P = 0.004) and higher peak late (Aa; P = 0.066) diastolic mitral annular velocities and therefore a lower Ea/Aa ratio (P = 0.041) as compared with noncarriers
The HSD3B1 T/C polymorphism cannot be used as genetic marker for the risk for recurrent spontaneous abortions in our Caucasian population.
LH induction of 3beta-HSD in nonpregnant mouse endometrium.
HIF-1alpha is constitutively present in the Leydig cells of the murine testis, where it potentially regulates Hsd3b1 transcription, and thus male reproductive function.
It was concluded that the presence of apelin/APLNR in the CL of pigs and stimulatory effects of apelin on progesterone secretion and 3beta-HSD levels suggest potential auto/paracrine regulation by apelin in the luteal phase of the estrous cycle.
Glucocorticoid receptor binding to 3beta-HSD promoter is involved in the differential hepatic 3beta-HSD expression between boars and barrows.
We found that adiponectin and insulin alone regulates the expression of StAR, CYP11A1 and HSD3B1 genes and secretion of P4 and A4 by the porcine endometrial and myometrial tissue explants during early pregnancy and the oestrous cycle.
The effects of androgen blockade on the expression of 3beta-hydroxysteroid dehydrogenase (3beta-HSD), CYP17, and 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) in the porcine fetus are reported.
Study found that uncastrated Duroc pigs with the GG SNP5 genotype had significantly higher 3beta-HSD mRNA levels than did uncastrated Duroc pigs with other SNP5 genotypes.
New insights to the transcriptional regulation of 3betaHSD1 and 17betaHSD7 and further hints to their involvement in steroid metabolism.
Significant sequence variations were found in the 5'flanking region of the 3beta-HSD gene, where differences in the number of TTAT repeats and 3 SNP were observed in the different breeds
The expression of 3betaHSD mRNA was detected by the use of RT-PCR technique in all investigated samples isolated at different stages of pregnancy.
Genistein and daidzein have direct effects on porcine granulosa cell progesterone synthesis involving the inhibition of 3-beta-HSD enzyme activity.
Granulosa and theca of well-characterized large bovine follicles were isolated before and after the LH surge. CYP19A1, HSD3B1, and CYP17A1 transcripts were quantified by real-time PCR (qPCR) and the chromatin condensation was determined.
Mapped bo bovine chromosome 3
Serum free culture conditions significantly enhanced Cyp17 and Csh1 but not Hsd3b expression in trophoblast.
Zebrafish hsd3b1(Dre 9) functions like mammalian HSD3B2, whose deficiency leads to congenital adrenal hyperplasia.
3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids.
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1
, 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I
, 3-beta-HSD I
, 3-beta-hydroxy-5-ene steroid dehydrogenase
, 3-beta-hydroxy-Delta(5)-steroid dehydrogenase
, delta-5-3-ketosteroid isomerase
, hydroxy-delta-5-steroid dehydrogenase, 3 beta-and steroid delta-isomerase 1
, progesterone reductase
, short chain dehydrogenase/reductase family 11E, member 1
, steroid Delta-isomerase
, trophoblast antigen FDO161G
, hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
, 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1-like
, hydroxysteroid dehydrogenase-1, delta<5>-3-beta
, 3 beta-hydroxysteroid dehydrogenase 1
, 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase
, 3-beta-hydroxysteroid dehydrogenase/delta-5-delta-4 isomerase
, hydroxy-delta-MAY-steroid dehydrogenase, 3 beta- and steroid delta-isomerase
, 3beta-hydroxysteroid dehydrogenase/isomerase
, LOW QUALITY PROTEIN: 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1