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High HSD3B1 Expression is Associated with Cancer Progression in Breast Cancer.
Fungicide ziram may disrupt the placental steroid production. In the present study, we investigated the effects of ziram on steroid formation in human placental cell line JEG-3 cells and on HSD3B1 and aromatase (show CYP19A1 Proteins) in the human placenta. Ziram did not inhibit progesterone production in JEG-3 cells and HSD3B1 activity at 100muM... ziram is a potent inhibitor of human aromatase (show CYP19A1 Proteins).
This is the first study to indicate that 3beta-HSD (show CHST3 Proteins) type 1 is a potent prognostic factor in hormone-dependent breast cancer.
HSD3B1 is involved in aldosterone production, despite its lower levels of expression compared with HSD3B2 (show HSD3B2 Proteins), and also possibly associated with KCNJ5 (show KCNJ5 Proteins) mutation in aldosterone-producing adenoma.
Expression of the genes HSD3B1, HSD17B3 (show HSD17B3 Proteins), and SRD5A2 (show SRD5A2 Proteins) was significantly increased in BPH (show GLI3 Proteins) tissues compared to normal adjacent prostate tissues.
prostate cancer patients who harbored the heterozygous variant HSD3B1 (1245C) are more likely to develop to castration-resistant prostate cancer but do not have shorter time to biochemical recurrence, shorter survival time or higher mortality risk
No evidence to support that HSD3B1 is involved in aldosterone synthesis in the human adrenal cortex or that genetic variation in HSD3B1 affects blood pressure or hypertension.
Results indicate that orexin-A significantly enhanced the expression of 3beta-hydroxysteroid dehydrogenase (3beta-HSD (show CHST3 Proteins)) and the production of cortisol, and increased the phosphorylation of AKT (show AKT1 Proteins) protein in the NCI-H295R adrenocortical cells.
The AngII-NGFIB/NURR1 (show NR4A2 Proteins) pathway controls HSD3B1 expression.
The AAT haplotype of the HSD3B1 gene was significantly associated with increased risks of acne vulgaris in Han Chinese from the Southwest China.
Glucocorticoid receptor (show NR3C1 Proteins) binding to 3beta-HSD (show HAL Proteins) promoter is involved in the differential hepatic 3beta-HSD (show HAL Proteins) expression between boars and barrows.
We found that adiponectin and insulin (show INS Proteins) alone regulates the expression of StAR, CYP11A1 (show CYP11A1 Proteins) and HSD3B1 genes and secretion of P4 and A4 by the porcine endometrial and myometrial tissue explants during early pregnancy and the oestrous cycle.
The effects of androgen blockade on the expression of 3beta-hydroxysteroid dehydrogenase (3beta-HSD (show HAL Proteins)), CYP17 (show CYP17A1 Proteins), and 17beta-hydroxysteroid dehydrogenase (show HSD17B7 Proteins) type 1 (17beta-HSD1 (show SPAG8 Proteins)) in the porcine fetus are reported.
Study found that uncastrated Duroc pigs with the GG SNP5 genotype had significantly higher 3beta-HSD (show HAL Proteins) mRNA levels than did uncastrated Duroc pigs with other SNP5 genotypes.
Significant sequence variations were found in the 5'flanking region of the 3beta-HSD (show HAL Proteins) gene, where differences in the number of TTAT repeats and 3 SNP were observed in the different breeds
The expression of 3betaHSD mRNA was detected by the use of RT-PCR technique in all investigated samples isolated at different stages of pregnancy.
Genistein and daidzein have direct effects on porcine granulosa cell progesterone synthesis involving the inhibition of 3-beta-HSD enzyme activity.
Granulosa and theca of well-characterized large bovine follicles were isolated before and after the LH surge. CYP19A1 (show CYP19A1 Proteins), HSD3B1, and CYP17A1 (show CYP17A1 Proteins) transcripts were quantified by real-time PCR (qPCR) and the chromatin condensation was determined.
Serum free culture conditions significantly enhanced Cyp17 (show CYP17A1 Proteins) and Csh1 but not Hsd3b expression in trophoblast.
LH induction of 3beta-HSD (show HAL Proteins) in nonpregnant mouse endometrium.
HIF-1alpha (show HIF1A Proteins) is constitutively present in the Leydig cells of the murine testis, where it potentially regulates Hsd3b1 transcription, and thus male reproductive function.
3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids.
3 beta-hydroxysteroid dehydrogenase
, 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase
, hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
, 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1
, 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1-like
, 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I
, 3-beta-HSD I
, 3-beta-hydroxy-5-ene steroid dehydrogenase
, 3-beta-hydroxy-Delta(5)-steroid dehydrogenase
, delta-5-3-ketosteroid isomerase
, hydroxy-delta-5-steroid dehydrogenase, 3 beta-and steroid delta-isomerase 1
, progesterone reductase
, short chain dehydrogenase/reductase family 11E, member 1
, steroid Delta-isomerase
, trophoblast antigen FDO161G
, 3-beta-hydroxysteroid dehydrogenase/delta-5-delta-4 isomerase
, hydroxy-delta-MAY-steroid dehydrogenase, 3 beta- and steroid delta-isomerase
, hydroxysteroid dehydrogenase-1, delta<5>-3-beta
, 3 beta-hydroxysteroid dehydrogenase 1
, 3-beta-hydroxysteroid dehydrogenase