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Prostate 5aR1 levels were positively correlated with adjusted prostate most severe lesion scores. Downregulation of androgen receptor (show AR Proteins) and 5alpha-reductase 2, along with upregulation of 5a-reductase 1 in tumors may promote prostatic intraepithelial neoplasia and prostate cancer development in TRAMP (show DPT Proteins) mice
the Srd5a1 gene modulates ethanol consumption in a sex-dependent manner that is also contingent upon ethanol access condition and concentration
deletion of the Srd5a1 gene significantly decreased ethanol's anxiolytic effect in female mice, and chronic ethanol withdrawal severity was lower in female versus male mice
transcription of srd5a1 in brain is regulated by environmental factor-induced cytosine methylation in the promoter region.
The effects of deficiency or inhibition of S5AR1 on the risk of liver disease and insulin (show INS Proteins) resistance in male rats and mice are reported.
Thus, 5alpha-reductase may be required for the estrous cycle variations in affective behavior and 3alpha,5alpha-THP (show UMOD Proteins) levels of female mice.
results suggest that local steroid 5 alpha-reductase 1 messenger RNA expression in Withdrawal Seizure-Prone mouse brain may not change in parallel with local allopregnanolone content or withdrawal severity
The aim of the present study was to investigate the role of 5alpha-reductase type 1 for bone mass using Srd5a1-/- mice.
This study evaluates 5alpha-R type I and 3alpha-HSD (show DHRS9 Proteins) mRNA expression level in mouse brain by using in situ hybridization.
Data suggests that in male mice after social isolation, expression of Srd5a1 mRNA is specifically down-regulated in glutamatergic pyramidal neurons. In socially isolated mice, this down-regulation may account for the appearance of behavioral disorders.
The study described in this article shows that selected SRD5A1 and SRD5A2 (show SRD5A2 Proteins) polymorphisms can alter the levels of metabolic and hormonal parameters in patients with BPH (show GLI3 Proteins). Special attention should be paid to the SDR5A2 rs12470143 polymorphism, which is associated with a change in lipid profile, as well as with the inheritance and incidence rate of MetS (show ETV3 Proteins) among these patients.
Findings suggest that 5alpha-reductases (5-AR) isoenzymes could be explored as a therapeutic target for urothelial bladder cancer (UBC) with 5alpha-reductase inhibitors (5-ARI).
Studies indicate that enhanced 5alpha-reductase activity in subjects with polycystic ovary syndrome (PCOS) was associated with insulin (show INS Proteins) resistance (IR) rather than obesity.
Although 4-dione is the main source of 5alpha-dihydrotestosterone in human preadipocytes, production of this steroid by 5 alpha-reductase isoenzymes (SRD5A1, 2 and 3) mediates the inhibitory effect of both 4-dione and testosterone on preadipocyte differentiation.
SRD5A1 small-interfering RNA knockdown led to significant increase in progesterone receptor (show PGR Proteins)-B nuclear import, ectopic, whereas SRD5A1 overexpression resulted in remarkable inhibition of nuclear progesterone receptor (show PGR Proteins)-B in P4-treated cells. Repression of SRD5A1 activated progesterone receptor (show PGR Proteins)-B responsive gene, whereas overexpression of SRD5A1 possessed an inhibitory effect.
the genotypic distribution of 22 single nucleotide polymorphisms in SRD5A1 and SRD5A2 (show SRD5A2 Proteins) in a set of Spanish prostate cancer patients, were evaluated.
A total of 2 SNPs in SRD5A1-rs3822430 and rs1691053-were associated with prostate-specific antigen level at diagnosis.
In model cell lines of endometrial cancer, AKR1C2 (show AKR1C2 Proteins) and SRD5A1 have crucial roles in progesterone metabolism.
SRD5A1 rs166050C risk variant was associated with greater prostatic exposure to androsterone
Significantly higher levels of SRD5A1, AKR1C2 (show AKR1C2 Proteins), AKR1C3 (show AKR1C3 Proteins), and HSD17B10 (show HSD17B10 Proteins) mRNA were however found in bone metastases than in non-malignant and/or malignant prostate tissue
Steroid 5-alpha-reductase (EC 188.8.131.52) catalyzes the conversion of testosterone into the more potent androgen, dihydrotestosterone (DHT). Also see SRD5A2 (MIM 607306).
, 3-oxo-5-alpha-steroid 4-dehydrogenase 1
, SR type 1
, steroid 5-alpha-reductase 1
, type 1 5alpha-reductase
, 3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1
, 5-alpha reductase
, steroid 5-alpha-reductase type I
, steroid 5 alpha-reductase 1
, prostatic steroid 5-alpha-reductase type I
, 3-oxo-5-alpha-steroid 4-dehydrogenase 1-like