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Ganglion cell loss and vasculopathy observed in Mthfr+/- and Cbs (show CBS Proteins)+/- mouse retinas may be milder than expected, not because of compensatory increases of enzymes in remethylation/transsulfuration pathways, but because downstream transsulfuration pathway products GSH, taurine, and H2S are maintained at robust levels.
In summary, high folate intake during pregnancy leads to pseudo-MTHFR deficiency, disturbed choline/methyl metabolism, embryonic growth delay and memory impairment in offspring. These findings highlight the unintended negative consequences of supplemental folic acid.
Study demonstrated that maternal MTHFR deficiency (i.e., in utero MTHFR deficiency) and early life exposure to vigabatrin separately and together alter the levels of proteins in the glutamatergic synapse
Mildly hyperhomocysteinemic Mthfr+/- mice demonstrate reduced ganglion cell function, thinner NFL (show NEFL Proteins), and mild vasculopathy by 24 weeks.
DNA methylation (show HELLS Proteins) patterns in undifferentiated spermatogonia are relatively stable in culture over time under conditions of altered methionine and MTHFR levels.
Data from Mthfr knockout mice (in homozygous/heterozygous matings) suggest that maternal genotype contributes to sensitivity to arsenic as embryotoxin (i.e., genetic predisposition to fetal resorption/congenital malformation in arsenic poisoning).
our results support an interaction between mild neonatal stress, the MTHFR genotype and sex
investigation of Mthfr regulation in an in vivo mouse model revealed temporal- and tissue-specific regulation that supports important roles for MTHFR in the developing embryo, and in postnatal brain and male reproductive tissues
A possible mechanism for the epigenetic involvement of Mthfr deficiency is proposed in the gender-dependent regulation of proteins associated with plasticity of the excitatory synapse.
These results showed that methylenetetrahydrofolate reductase deficiency impairs endothelial progenitor cell formation and increases endothelial progenitor cell senescence by endothelial nitric oxide synthase (show NOS3 Proteins) uncoupling and downregulation of SIRT1 (show SIRT1 Proteins).
Suggest that MTHFR 677 variant confers risk for diabetic neuropathy among Iranian patients with type 2 diabetes.
that in MTHFR polymorphisms, the prevalence of 677CT genotype and T allele in C667T SNP influences susceptibility to migraine with aura (show AURKA Proteins) but not to without aura (show AURKA Proteins)
MTHFR SNPs are associated with susceptibility to osteoporosis and osteoporotic vertebral compression fractures in postmenopausal women.
Polymorphisms of the genes MTHFR (rs1801133) and APOA5 (show APOA5 Proteins) (rs662799), as well as anemia, are independent risk factors for stroke in Mexicans, together with traditional cardiovascular risk factors such as high triglycerides and high blood pressure.
Serum folate and total homocysteine levels are influenced by folate intake and genetic polymorphisms in the MTHFR gene, such as C677T. (Review)
MTHFR polymorphism is associated with breast cancer susceptibility.
This study demonstrated that MTHFR polymorphism was associated with hepatocellular carcinoma (HCC (show FAM126A Proteins)) occurrence and post-transplant recurrence
The MTHFR C667T polymorphism is not predictive for toxicity in methotrexate-induced toxicity in pediatric osteosarcoma patients.
Data suggest that C-reactive-protein (CRP (show CRP Proteins)) concentration is weakly associated with global DNA methylation (show HELLS Proteins) level, and this association was more clearly in individuals with the minor allele of the 5,10-methylenetetrahydrofolate reductase (MTHFR)missense SNP rs1801133
The results of the meta-analysis suggested that MTHFR C677T polymorphism was associated with colorectal cancer susceptibility, especially in Asian population.
The protein encoded by this gene catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine. Genetic variation in this gene influences susceptibility to occlusive vascular disease, neural tube defects, colon cancer and acute leukemia, and mutations in this gene are associated with methylenetetrahydrofolate reductase deficiency.
, 5,10-methylenetetrahydrofolate reductase (NADPH)
, methylenetetrahydrofolate reductase (NAD(P)H)
, methylenetetrahydrofolate reductase-like
, methylenetetrahydrofolate reductase