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KIF2A expression was increased in human ovarian cancer patients and in tumor tissues and KIF2A mRNA contains two target sites for miR (show MLXIP Proteins)-206 binding and confirmed that miR (show MLXIP Proteins)-206 directly suppresses KIF2A; inhibits ovarian cancer cell proliferation, migration, and invasion; and induces apoptosis.
Furthermore, silencing KIF2A inhibited cell proliferation and induced apoptosis in lung adenocarcinoma(LUAD) cells. In conclusion, KIF2A may serve as a valuable prognostic indicator and promising therapeutic target of LUAD.
have identified a conserved WDR5 (show WDR5 Proteins) interaction (Win) motif, so far unique to the Mixed-lineage leukemia family
The effect of Kif2A Knockdown on spreading could be rescued by expression of Kif2A-GFP or FLAG-AGAP1 (show AGAP1 Proteins), but not by Kif2C (show KIF2C Proteins)-GFP. The results support the hypothesis that the Kif2A.AGAP1 complex contributes to control of cytoskeleton remodeling involved in cell movement.
Study used high-resolution single-molecule microscopy to directly observe the stepping behavior of kinesin-1 and -2 family motors with different length neck-linker domains. Results provide a kinetic framework for explaining kinesin processivity and for mapping structural differences to functional differences in diverse kinesin isoforms.
these data provide the first evidence that increased KIF2A expression predicts poor prognosis in patients with diffuse large B cell lymphoma, and a rationale for treatment of DLBCL by targeting KIF2A.
The MuvB multiprotein complex, together with B-MYB (show MYBL2 Proteins) and FOXM1 (show FOXM1 Proteins) (MMB-FOXM1 (show FOXM1 Proteins)) regulate the expression of mitotic kinesins in breast cancer cells.
Mdp3 (also known as MAP7D3) forms a complex with DDA3 (show PSRC1 Proteins) (also known as PSRC1 (show PSRC1 Proteins)) and controls spindle dynamics at the minus end of Microtubuless by inhibiting DDA3 (show PSRC1 Proteins)-mediated Kif2a recruitment to the spindle.
High KIF2A expression is associated with Gastric Cancer.
KIF2A may be important in glioma progression.
These data indicate that KIF2A regulates the spindle assembly, asymmetric cytokinesis and the metaphase I-anaphase I transition in mouse oocyte.
Kif2a may act as a microtubule depolymerase, regulating microtubule dynamics, spindle assembly and chromosome congression, and thus cell cycle progression during mouse oocyte meiotic maturation.
We further found that knockdown of Kif2a decreased the protein level of b-catenin, which is a critical molecule for neocortical neurogenesis. Together, these results reveal an important function of Kif2a in embryonic neocortical neurogenesis
Tubulin (show TUBB Proteins) is transported in a non-particulate form requiring kinesin-2.
Authors identified two different sets of KIF2A phosphorylation profiles that accelerate (A-type) and brake (B-type) the MT depolymerization activity of KIF2A.
Kif2a is a pruning factor that regulates target innervation by sensory axons.
This study provided evidence from live-cell analysis that the conserved heterotrimeric kinesin-2 is required for the normal transport of opsin (show RHO Proteins) along the ciliary plasma membrane.
Kif2a functions in suppression of collateral extension.
Interaction between kif2a and importin-alpha could be the mechanism by which spindle and cell sizes are coordinated early in development.
Kif2a is required for the epiboly (spreading) of animal cap. In animal caps (show CAPS Proteins), Kif2a localizes to the spindle poles (centrosomes) and centromeres during mitosis and is required for spindle integrity and proper chromosome segregation.
The protein encoded by this gene is a plus end-directed motor required for normal mitotic progression. The encoded protein is required for normal spindle activity during mitosis and is necessary for normal brain development. Several transcript variants encoding different isoforms have been found for this gene.
Kinesin, heavy chain, 2
, kinesin-like protein KIF2A
, kinesin heavy chain member 2
, kinesin family member 2A
, kinesin heavy chain family, member 2
, kinesin-related protein XKIF2
, kinesin heavy chain member 2A