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GSK3beta-SKAP (show KNSTRN Proteins)-Kif2b signaling axis constitutes a dynamic link between spindle microtubule plus-ends and mitotic chromosomes to achieve faithful cell division.
Data indicate that Cep170 association with the C-terminus of Kif2b enhances localization of Kif2b to the spindle.
Data show that Polo-like kinase 1 (Plk1) regulates both the localization and activity of kinesin-13 protein Kif2b during mitosis to promote the correction of k-MT attachment errors to ensure mitotic fidelity.
Data show that CLASP1 (show CLASP1 Proteins)-astrin (show SPAG5 Proteins)-Kif2b complex acts as a central switch at kinetochores that defines mitotic progression and promotes fidelity by temporally regulating kinetochore-microtuble attachments.
when microtubules are absent, the neck linker exists in equilibrium between two structural states; microtubule binding may activate the nucleotide-sensing mechanism of kinesin
kinesin-I-dependent neuronal AbetaPP transport, which controls AbetaPP processing, may be regulated by JIP1 (show MAPK8IP1 Proteins)
These data demonstrate that Kif2b function is required for spindle assembly and chromosome movement and that the microtubule depolymerase activities of Kif2a (show KIF2A Proteins), Kif2b, and MCAK (show KIF2C Proteins) fulfill distinct functions during mitosis in human cells.
Here we show that two microtubule-depolymerizing kinesins, Kif2b and MCAK, stimulate kinetochore-microtubule dynamics during distinct phases of mitosis to correct mal-orientations.
Plus end-directed microtubule-dependent motor required for spindle assembly and chromosome movement during mitosis. Has microtubule depolymerization activity (By similarity).
kinesin-like protein KIF2B
, kinesin protein
, kinesin family member 2B
, kinesin-like protein KIF2B-like
, LOW QUALITY PROTEIN: kinesin-like protein KIF2B
, Kinesin-like protein KIF2B