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RhoA activated the downstream Wnt/betacatenin signaling pathway and inhibited the expression of apoptotic factors.
We identify HGF (show HGF Proteins), acting through the c-Met receptor, as the key polarity-inducing morphogen (show SHH Proteins), which acts to activate b1-integrin-dependent adhesion. HGF (show HGF Proteins) and ECM (show MMRN1 Proteins)-derived integrin signals co-operate via a c-Src (show SRC Proteins)-dependent inhibition of the RhoA-ROCK1 (show ROCK1 Proteins) signalling pathway via p190A (show GRLF1 Proteins) RhoGAP (show ARHGAP1 Proteins)
Extracellular Hsp90alpha mediates house dust mite-induced human bronchial epithelial barrier dysfunction by activating RhoA/MLC signaling, suggesting that eHsp90alpha is a potential therapeutic target for treatment of asthma.
This analysis showed a relative increase in the expression of E2F6 (show E2F6 Proteins) in gastric adenocarcinoma with no lymph node metastasis (chi (2), P = 0.04 and OR, P = 0.08), while overexpression of RhoA and SMUG1 (show SMUG1 Proteins) was found more often in the diffuse subtype of gastric adenocarcinoma as compared to the intestinal subtype.
This is the first study to verify the relationship of the expression of RhoA and Ezrin (show EZR Proteins) proteins in vaginal tissue of Postmenopausal atrophic vagina.
blockage of RhoA/ROCK repressed the TAK1 (show MAP3K7 Proteins)/NOD2-mediated NF-kappaB (show NFKB1 Proteins) pathway in HaCaT cells exposed to UVB.
data suggest that TGF-beta (show TGFB1 Proteins) stimulated the expression of ChPF (show CHPF Proteins) and sGAG synthesis in nucleus pulposus cells through Smad3 (show SMAD3 Proteins), RhoA/ROCK1 (show ROCK1 Proteins) and the three MAPK (show MAPK1 Proteins) signaling pathways.
a SDF-1 (show CXCL12 Proteins)/CXCR4 (show CXCR4 Proteins)-RhoA and RhoC (show RHOC Proteins)-ROS (show ROS1 Proteins)-cytoskeleton pathway that regulates Jurkat cell migration in response to SDF-1 (show CXCL12 Proteins).
DIAPH3 (show DIAPH3 Proteins) overexpression inhibits the migration and invasion of Triple-negative breast cancer by inhibiting RhoA-GTP (show AK3 Proteins) expression.
Tyr42 phosphorylation of RhoA GTPase promotes tumorigenesis through NF-kappaB (show NFKB1 Proteins).
GTP (show AK3 Proteins)-RhoA and ROCK1 (show ROCK1 Proteins) expression levels were markedly increased in a time-dependent manner in the ears and lungs of mice treated with penicillin.
RhoA modulates the choices of molar cuspal shape by coordinating adhesion junctions, actin distribution, and fibronectin (show FN1 Proteins) localization to drive inner dental epithelium invagination.
Kctd13 deletion reduces synaptic transmission, which correlates with increased levels of RhoA, a KCTD13/CUL3 ubiquitin ligase substrate
Crmp4(-/-) OBs exhibited enhanced activation of RhoA/focal adhesion kinase (FAK) signaling that led to cytoskeletal changes with increased cell spreading.
Codepletion of the actomyosin regulator RhoA and Afadin results in defects in the central lumens and arrests lumen remodeling
Hydrogen peroxide oxidizes RhoA at Cys16 and Cys20, and activates RhoA via Vav2.
These results reveal a novel signaling network, the Sema4D (show SEMA4D Proteins)-RhoA-Akt (show AKT1 Proteins) signal cascade, that coordinates cellular function and morphology and highlights the importance of specific spatiotemporally restricted components of a signaling pathway in the regulation of ameloblast differentiation.
RhoA deficiency could disrupt podocyte cytoskeleton and induce podocyte apoptosis by inhibiting YAP/dendrin signal.
These results suggested that, in addition to inhibiting Noggin (show NOG Proteins) transcription, RhoA activity in wild-type murine embryonic stem cells also prevented neural differentiation by limiting Noggin (show NOG Proteins) secretion.
Mgc's GAP activity down-regulates the active populations of RhoA and Rac1 at localized regions of epithelial cells and is necessary for successful cytokinesis and cell-cell junction structure
Data show that shortly after anaphase onset oocytes and embryonic cells exhibit cortical waves of Rho activity and F-actin polymerization.
CASZ1/Egfl7 (show EGFL7 Proteins)/RhoA pathway is necessary for promoting endothelial cell behaviors associated with proper vascular assembly.
RhoA can be considered a component of the intracellular pattern formation system.
Kazrin (show KAZ Proteins) interacts with ARVCF (show ARVCF Proteins)-catenin, spectrin and p190B RhoGAP (show ARHGAP1 Proteins), and modulates RhoA activity.
Morphogenesis of the primitive gut tube is generated by Rho/ROCK/myosin II-mediated endoderm rearrangements.
RhoA and membrane fluidity mediates the spatially polarized Src (show SRC Proteins)/FAK (show PTK2 Proteins) activation in response to shear stress.
the Lbc/alpha-catulin (show CTNNAL1 Proteins) axis participates in 5-HT (show DDC Proteins)-induced PASMC mitogenesis and RhoA/ROCK signaling, and may be an interventional target in diseases involving vascular smooth muscle remodeling.
The RhoA/ROCK signaling pathway is an important negative regulator of vascular calcification.
Vascular endothelial-cadherin signals through RhoA and actin cytoskeletal and affects cell-matrix adhesion
Thrombospondin has a role in inducing RhoA inactivation through FAK (show PTK2 Proteins)-dependent signaling to stimulate focal adhesion disassembly
KCl directly increased Rho and ROCK activities in a concentration-dependent fashion that paralleled closely the effect of KCl on lung smooth muscle tone and [Ca(2 (show CA2 Proteins)+)](i), as well as the voltage-dependent Ca(2 (show CA2 Proteins)+) currents
the Rho-ROCK signal pathway contributes to VEGF (show VEGFA Proteins)-induced hyperpermeability. Myosin light-chain phosphorylation and actin stress fiber formation occur concomitantly with the increase in permeability upon VEGF (show VEGFA Proteins) stimulation.
Formation of polygonal actin network in endothelial cells is a novel rhoA associated response to hypertonic stress.
Cadherins, RhoA and Rac1, have important roles in mechanotransduction and that endothelial and smooth muscle cells use different mechanisms to respond to stretch.
Results indicate that hypergravity induces ATP release and actin reorganization via RhoA activation and FAK (show PTK2 Proteins) phosphorylation, thereby activating cell proliferation and migration in bovine aortic endothelial cells.
Pseudorabies virus US3 expression led to RhoA phosphorylation at serine 188 to induce actin rearrangements.
Data indicate that TNF-alpha (show TNF Proteins) stimulates Rac (show AKT1 Proteins), ADAM17/TACE (show ADAM17 Proteins), and RhoA through the guanine nucleotide exchange factor (show ARHGEF12 Proteins) (GEF)-H1 (show ARHGEF2 Proteins).
Contractile pulmonary arterial myocytes exhibit marked Rho-dependent actin polymerization in hypoxia, with increased active RhoA and LIMK (show LIMK1 Proteins) phosphorylation.
Results suggest that Rac1 and RhoA are regulated by TGFbeta1 (show TGFB1 Proteins) in the process of endothelial tube formation in collagen I gels.
The concentration of RhoA mRNA and activated RhoA enzyme were greater in urothelium than in detrusor. Rho kinase (show ROCK1 Proteins) inhibitor Y-27632 showed a stronger inhibitory effect in detrusor with intact urothelium.
Thrombin stimulates swine smooth muscle cell differentiation from peripheral blood mononuclear cells via protease-activated receptor-1, RhoA, and myocardin.
Activating Rho could be beneficial to suppress Kras mutant-induced liver malignancies.
Ras homolog, or Rho, proteins interact with protein kinases and may serve as targets for activated GTPase. They play a critical role in muscle differentiation. The protein encoded by this gene binds GTP and is a member of the small GTPase superfamily. It is involved in endosome dynamics and reorganization of the actin cytoskeleton, and it may coordinate membrane transport with the function of the cytoskeleton.
Aplysia ras-related homolog 12
, oncogene RHO H12
, ras homolog gene family, member A
, rho cDNA clone 12
, small GTP binding protein RhoA
, transforming protein RhoA
, Rho-related protein HP1
, ras homolog D
, ras homolog gene family, member D
, rho-related GTP-binding protein RhoD
, Ras family member A
, Rho family GTPase
, aplysia ras-related homolog A
, aplysia ras-related homolog A1
, aplysia ras-related homolog A2
, ras homolog A1
, ras homolog A2
, ras homolog gene family, member A1
, ras homolog gene family, member A2
, plysia ras-related homolog A2
, rho1 GTP-binding protein
, RhoA GTPase
, Rho A