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The results identify a significant genotypic association between Primary open-angle glaucoma (POAG) and RHOA gene rs974495 polymorphism.
Our findings indicate that NRF2 (show GABPA Proteins) silencing-mediated reduction of RhoA expression contributes, at least in part, to the poor outcome of breast cancer patients with high NRF2 (show GABPA Proteins) expression.
RHOA, and its oncogenic signaling pathway, represent a strong biomarker-driven therapeutic target for Asian gastric cancer.
this study shows that C5a receptor (CD88 (show C5AR1 Proteins)) promotes motility and invasiveness of gastric cancer by activating RhoA
CD44 (show CD44 Proteins) and RHOA are required for CFL1 (show VPS72 Proteins) phosphorylation and cell migration induced by CD74 (show CD74 Proteins) in breast cancer cells.
Out of multiple members of this family, RhoA and RhoC (show RHOC Proteins) are important factors. RhoA is supposed to increase tumor proliferation when overexpressed while RhoC (show RHOC Proteins) is responsible for tumor initiation.
These results indicate that aberrant alternative splicing of RHOA results in the loss of its activity and expression in DGC (show GGCX Proteins) cells.
Spatiotemporal analysis of RhoA/RhoB/RhoC (show RHOC Proteins) activation in primary human endothelial cells has been uncovered.
MDA-9 (show SDCBP Proteins) upregulated active levels of known modulators of epithelial mesenchymal transformation, the small GTPases RhoA and Cdc42 (show CDC42 Proteins), via TGFbeta1 (show TGFB1 Proteins), promoting lung metastasis of breast cancer cells.
Results indicate that miR (show MLXIP Proteins)-126 acts as a tumor suppressor by inactivating RhoA signaling via CXCR4 (show CXCR4 Proteins) in colon cancer.
Crmp4(-/-) OBs exhibited enhanced activation of RhoA/focal adhesion kinase (FAK) signaling that led to cytoskeletal changes with increased cell spreading.
Codepletion of the actomyosin regulator RhoA and Afadin results in defects in the central lumens and arrests lumen remodeling
Hydrogen peroxide oxidizes RhoA at Cys16 and Cys20, and activates RhoA via Vav2.
These results reveal a novel signaling network, the Sema4D (show SEMA4D Proteins)-RhoA-Akt (show AKT1 Proteins) signal cascade, that coordinates cellular function and morphology and highlights the importance of specific spatiotemporally restricted components of a signaling pathway in the regulation of ameloblast differentiation.
RhoA deficiency could disrupt podocyte cytoskeleton and induce podocyte apoptosis by inhibiting YAP/dendrin signal.
These results suggested that, in addition to inhibiting Noggin (show NOG Proteins) transcription, RhoA activity in wild-type murine embryonic stem cells also prevented neural differentiation by limiting Noggin (show NOG Proteins) secretion.
Rho attenuates the interaction between Amot (show AMOT Proteins) and Nf2 (show NF2 Proteins) by binding to the coiled-coil domain of Amot (show AMOT Proteins).
we uncovered cell state plasticity and adhesion dynamics regulated by Ror2 (show ROR2 Proteins), which influenced Ras Homology Family Member A (show CXCL14 Proteins) (RhoA) and Rho-Associated Coiled-Coil Kinase 1 (ROCK1 (show ROCK1 Proteins)) activity downstream of Dishevelled-2 (Dvl2 (show DVL2 Proteins)).
Active Rho-kinase (show ROCK2 Proteins) diffuses to growing other immature neurites and inhibits their outgrowth to ensure single axon formation.
Data indicate that oxidative stress in diabetes causes a decrease in miR (show MLXIP Proteins)-133a expression leading to an increase in RhoA/Rho kinase (show ROCK2 Proteins) pathway and muscle contraction.
Mgc's GAP activity down-regulates the active populations of RhoA and Rac1 at localized regions of epithelial cells and is necessary for successful cytokinesis and cell-cell junction structure
Data show that shortly after anaphase onset oocytes and embryonic cells exhibit cortical waves of Rho activity and F-actin polymerization.
CASZ1/Egfl7 (show EGFL7 Proteins)/RhoA pathway is necessary for promoting endothelial cell behaviors associated with proper vascular assembly.
RhoA can be considered a component of the intracellular pattern formation system.
Kazrin (show KAZ Proteins) interacts with ARVCF (show ARVCF Proteins)-catenin, spectrin and p190B RhoGAP (show ARHGAP1 Proteins), and modulates RhoA activity.
Morphogenesis of the primitive gut tube is generated by Rho/ROCK/myosin II-mediated endoderm rearrangements.
RhoA and membrane fluidity mediates the spatially polarized Src (show SRC Proteins)/FAK (show PTK2 Proteins) activation in response to shear stress.
the Lbc/alpha-catulin (show CTNNAL1 Proteins) axis participates in 5-HT (show DDC Proteins)-induced PASMC mitogenesis and RhoA/ROCK signaling, and may be an interventional target in diseases involving vascular smooth muscle remodeling.
The RhoA/ROCK signaling pathway is an important negative regulator of vascular calcification.
Vascular endothelial-cadherin signals through RhoA and actin cytoskeletal and affects cell-matrix adhesion
Thrombospondin has a role in inducing RhoA inactivation through FAK (show PTK2 Proteins)-dependent signaling to stimulate focal adhesion disassembly
KCl directly increased Rho and ROCK activities in a concentration-dependent fashion that paralleled closely the effect of KCl on lung smooth muscle tone and [Ca(2 (show CA2 Proteins)+)](i), as well as the voltage-dependent Ca(2 (show CA2 Proteins)+) currents
the Rho-ROCK signal pathway contributes to VEGF (show VEGFA Proteins)-induced hyperpermeability. Myosin light-chain phosphorylation and actin stress fiber formation occur concomitantly with the increase in permeability upon VEGF (show VEGFA Proteins) stimulation.
Formation of polygonal actin network in endothelial cells is a novel rhoA associated response to hypertonic stress.
Cadherins, RhoA and Rac1, have important roles in mechanotransduction and that endothelial and smooth muscle cells use different mechanisms to respond to stretch.
Results indicate that hypergravity induces ATP release and actin reorganization via RhoA activation and FAK (show PTK2 Proteins) phosphorylation, thereby activating cell proliferation and migration in bovine aortic endothelial cells.
Pseudorabies virus US3 expression led to RhoA phosphorylation at serine 188 to induce actin rearrangements.
Data indicate that TNF-alpha (show TNF Proteins) stimulates Rac (show AKT1 Proteins), ADAM17/TACE (show ADAM17 Proteins), and RhoA through the guanine nucleotide exchange factor (show ARHGEF12 Proteins) (GEF)-H1 (show ARHGEF2 Proteins).
Contractile pulmonary arterial myocytes exhibit marked Rho-dependent actin polymerization in hypoxia, with increased active RhoA and LIMK (show LIMK1 Proteins) phosphorylation.
Results suggest that Rac1 and RhoA are regulated by TGFbeta1 (show TGFB1 Proteins) in the process of endothelial tube formation in collagen I gels.
The concentration of RhoA mRNA and activated RhoA enzyme were greater in urothelium than in detrusor. Rho kinase (show ROCK1 Proteins) inhibitor Y-27632 showed a stronger inhibitory effect in detrusor with intact urothelium.
Thrombin stimulates swine smooth muscle cell differentiation from peripheral blood mononuclear cells via protease-activated receptor-1, RhoA, and myocardin.
Activating Rho could be beneficial to suppress Kras mutant-induced liver malignancies.
Ras homolog, or Rho, proteins interact with protein kinases and may serve as targets for activated GTPase. They play a critical role in muscle differentiation. The protein encoded by this gene binds GTP and is a member of the small GTPase superfamily. It is involved in endosome dynamics and reorganization of the actin cytoskeleton, and it may coordinate membrane transport with the function of the cytoskeleton.
Aplysia ras-related homolog 12
, oncogene RHO H12
, ras homolog gene family, member A
, rho cDNA clone 12
, small GTP binding protein RhoA
, transforming protein RhoA
, Rho-related protein HP1
, ras homolog D
, ras homolog gene family, member D
, rho-related GTP-binding protein RhoD
, Ras family member A
, Rho family GTPase
, aplysia ras-related homolog A
, aplysia ras-related homolog A1
, aplysia ras-related homolog A2
, ras homolog A1
, ras homolog A2
, ras homolog gene family, member A1
, ras homolog gene family, member A2
, plysia ras-related homolog A2
, rho1 GTP-binding protein
, RhoA GTPase
, Rho A